Rozhgar A. KHAİLANY, Mustafa S. AL-ATTAR, Amer A. HASAN

Erbil’de meme kanseri hastalarında P53 geni ekspresyonundaki değişikliklerin ilişkisi

Amaç: Meme kanseri, dünyadaki kadınlarda ölümcül en büyük hastalık ve kanser ölümünün önde gelen nedenidir. P53, tümör baskılayıcı bir gen, insan kanserleri ile ilişkili olduğu bilinen ve insan kanserlerinin% 50'sinden fazlası,esas görevi genomun koruyucusu olan P53 geninin alterasyonunu içerir. Bu çalışmada, Erbil ilindeki meme kanseri hastalarında P53 geninin mRNA ekspresyon düzeyini değerlendirmeyi amaçladık.

Anahtar Kelimeler:

Meme kanseri, P53, ekspresyon analizi, yarı kantitatif RT-PCR

Association of P53 gene expression alteration among breast cancer patients in Erbil province

Purpose: Breast cancer is the most lethal disease and the leading cause of cancer death among women in worldwide. P53, a tumor-suppressor gene, is best known to be associated with human cancers and more than 50% of human cancers contain P53 alteration, which is guardian of the genome. In the current study, we aimed to evaluate mRNA expression level of P53 gene among breast cancer patients in Erbil province.

Keywords:

Breast cancer, P53, expression analysis, semi-quantitative RT-PCR,

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