2015

D vitamini eksikliğinin yaşlı hastalarda osteoartrit ve kemik mineral dansitesi üzerine etkisi

Amaç: Farklı kemik mineral yoğunluğu (KMY) olan kadın ve erkek erken ve geç evre osteoartritli (OA) yaşlılarda, vitamin D düzeyinin OA ve KMY üzerine etkisini ve ayrıca D vitamini ve diz fonksiyon skorları arasındaki ilişkiyi belirlemeyi amaçladık. Gereç ve Yöntem: Çalışmaya diz OA olan yüz kırk iki kadın ve yüz otuz beş erkek hasta alındı. Diz OA erken ve geç evre olarak sınıflandırıldı. Western Ontario ve McMaster Universities Osteoarthritis indexi (WOMAC) indeksi, Knee Injury ve Osteoarthritis Outcome Skoru (KOOS) hesaplandı ayrıca KMY ve D vitamini düzeyleri ölçüldü. Bulgular: Kadın OA de D vitamini düzeyleri erkek OA grubuna göre istatistiksel olarak anlamlı derecede düşüktü. Kadın OA hastalarında kalsiyum ve fosfor düzeyleri erkek OA grubuna göre anlamlı olarak daha yüksekti. Osteoporoz, osteopeni ve normal KMY olan erken ve geç dönem OA hastalarında vitamin D, vitamin B12, kalsiyum, fosfor, WOMAC indeksi ve KOOS skorları arasında fark yoktu. Osteoporozlu erken evre ve geç evre OA olan erkek hastalarda osteopenisi ve normal KMY olanlara göre WOMAC indexi anlamlı olarak daha yüksekti. Kadın OA olan hastalarda yaş odds oranı (OR) 1,047 (% 95 CI = 1,009-1,086), erkek OA olan hastalarda OR = 1.090 (% 95 CI = 1,021-1,163) idi. Sonuç: D vitamini takviyesinin, osteoporozun ilerlemesini yavaşlattığı, ağrıyı azalttığı, KMY arttırdığı söylenebilir, ancak OA progresyonu ve diz fonksiyon skorları üzerinde hiçbir etkisi yoktur.

Effect of vitamin D deficiency on osteoarthritis and bone mineral density in elderly patients

Purpose: We aimed to determine the effect of inadequatevitamin D level on osteoartritis (OA) and bone mineraldensity (BMD) in female and male elderly patients withearly and late stage OA with different BMD, and also therelationship between vitamin D and knee function scoresin female and male OA patients.Materials and Methods: One hundred and fortytwofemale and one hundred thirty-five male knee OA patientswere enrolled in the study. The knee OA was classified asearly and late stage. WOMAC score, KOOS score, BMDand Vitamin D levels were measured.Results: Vitamin D levels patients were statisticallysignificantly lower in female OA than male OA group.Calcium and phosphorus levels were significantly higher infemale OA patients than male OA group. There was nodifference between vitamin D, vitamin B12, calcium,phosphorus, WOMAC score and KOOS scores in earlyand late stage OA patients with osteoporosis, osteopeniaand normal BMD. WOMAC score was significantlyhigher in male patients with osteoporosis early stage andlate stage OA than patients with osteopenia and normalBMD. The age odds ratio (OR) was 1,047 (95% CI =1,009-1,086) in female OA patients, and OR was 1.090(95% CI = 1,021-1,163) in male OA patients.Conclusion: Vitamin D supplementation may be saidincrease BMD, slow down the progression ofosteoporosis, reduce pain, but have no effect on OAprogression and knee function scores.

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