Tevfik BALCI, Durmuş AYAN, Cevdet TÜRKYÜREK, Ergül BAYRAM

Beta talasemi minör ve demir eksikliği anemisinin ayırıcı tanısında eritrosit indekslerinin tanısal doğruluk testlerinin değerlendirilmesi: ön çalışma raporu

Amaç: En sık görülen anemiler demir eksikliği anemisi (DEA) ve beta-talasemi minördür (BTm). Bunların doğru bir şekilde ayırt edilmesi, gereksiz demir tedavisinin önlenmesi ve talasemi hastalığının önlenmesi açısından önemlidir. Özellikle talasemi prevalansının yüksek olduğu ülkelerdeki finansal kısıtlılıklar göz önüne alındığında, ayırıcı tanıya ulaşmak için daha basit çözümler olan matematiksel indeksler kullanılmıştır. Gereç ve Yöntem: Dahil edilme kriterlerine uygun toplam 71 vaka çalışmaya dahil edildi ve 11 indeks incelendi. Vakaların 46'sı BTm grubunda, 25'i ise IDA grubundaydı. BTm grubu pozitif hasta grubu, DEA grubu kontrol grubu olarak kabul edildi. Tanı kriterleri eritrosit indeksleri ile değerlendirildi. Bulgular: En yüksek Youden İndeksi Sirdah indeksinde (%89,48) görüldü, ardından Ehsani ve Mentzer indekslerinin iki özdeş performansı (%84,00) bu üç indeksin en iyi tanısal performansı gösterdiğini gösteriyor. Düşük performanslı (DOR

Anahtar Kelimeler:

Eritrosit indeksleri, ayırıcı, tanı, beta talasemi minör, demir eksikliği anemisi

Evaluation of diagnostic accuracy tests of erythrocyte indexes in the differential diagnosis of beta thalassemia minor and iron deficiency anemia: A preliminary report

Purpose: The most common anemias are iron deficiency anemia (IDA) and beta-thalassemia minor (BTm). A correct differantiation of them is important in terms of preventing unnecessary iron treatment and also preventing thalassemia disease. Considering the financial limitations specifically in countries with high prevalence of thalassemia, mathematical indices, which are simpler solutions, have been used to achieve a differential diagnosis. Materials and Methods: Total of 71 cases eligible for inclusion criteria were included in the study and 11 indices were examined. 46 of the cases were in the BTm-group and 25 of the cases were in the IDA-group. The BTm-group were accepted as positive-patient-group and the IDA-group were accepted as control-group. Diagnostic criteria were evaluated with erythrocyte indices. Results: The highest Youden Index was seen in the Sirdah index (89.48%), followed by two identical performances of the Ehsani and the Mentzer indices (84.%), indicating that these three indices showed the best diagnostic performance. There were two indices with a low performance (DOR

Keywords:

erythrocyte indices, differential, diagnosis, beta thalassemia minor, iron deficiency anemia,

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