Yasemin GÜNEŞ, Tufan MERT, Dilek ÖZCENGİZ, İsmail GÜNAY

Ağrının İletilmesinde N-Metil D- Aspartat Reseptörlerinin Rolü

Amaç : Yapılan deneysel çalışmalar, NMDA (N-methyl-D-aspartate) reseptörlerinin ağrı tedavilerine yönelik kullanılan ilaçların etki mekanizmalarında en önemli etken mekanizmalardan biri olabileceğini gösterilmiştir. Spinal kord dorsal boynuzda yer alan NMDA reseptörleri santral sensitizasyon için esastır, periferik yaralanmada santral sensitizasyon ağrının iletilmesinde rol oynar. Bu çalışmada NMDA reseptör agonisti ve antagonisti kullanarak periferal NMDA reseptörlerinin ağrı bilgisinin iletilmesindeki katkılarına yönelik yeni bilgilere ulaşmak amaçlandı. Gereç-Yöntem : Çalışmada, sıçanlara intraplantar olarak uygulanan N metil aspartik asit (NMDA) ve antagonisti olan MK-801’nin doz ve zamana bağlı olarak sıçanların geri çekme latansına etkileri termal plantar test yöntemi kullanılarak araştırıldı. Bulgular : MK-801 doza bağlı olarak termal anti-nosiseptif etkiler oluştururken, NMDA termal latansta azalma meydana getirerek hiperaljezinin ortaya çıkmasına neden oldu. Sonuç : Periferal NMDA reseptörlerinin ağrı bilgisinin iletilmesinde dominant bir rol oynayabileceğini göstermektedir.

Anahtar Kelimeler:

NMDA, MK-801, İntraplantar, Hiperaljezi, Antinosisepsiyon

The Role of N-Methyl D-Aspartate Receptors on Pain Transmission

Aim : In the experimental studies, NMDA (N-methyl-D-aspartate) receptors play important role in the mechanism of action among the drugs used for the treatment of pain. The NMDA receptors in the dorsal horn of spinal cord is essential for central sensitization and the central facilitation of pain transmission produced by peripheral injury. The aim of this study was to evaluate the contributions of peripheral NMDA receptor agonist and antagonists in peripheral pain transmission. Material-Method : In the present study, N methyl aspartic acid (NMDA) and antagonist ( MK-801) were administered intraplantarily to investigate withdrawal effects, the dose and time dependent latency using thermal plantar test method in rats. Results : MK-801 caused dose-dependent thermal anti-nociceptive effects, whereas NMDA led to reduction in the thermal nociceptive latency and hyperalgesia. Conclusion : Peripheral NMDA receptors may play a dominant role in the transmission of pain information.

Keywords:

NMDA, MK-801, intraplantary, hyperalgesia, antinociception,

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