Amaç: Poliartiküler, oligoartiküler Juvenil İdiopatik Artritlerin (JİA) izleminde HLA gruplarını ve hastalık aktivitesini yansıtan laboratuvar verilerini değerlendirmek, kıyaslamak, tedaviye yanıtsız hastalıkla en iyi örtüşen laboratuvar verilerini araştırmaktı. Yöntem: Aralık 1996 - Ocak 2002 tarihleri arasında hastanemiz çocuk romatoloji polikliniğine başvuran en az 2 yıl izlenmiş olan yaşları 3-14 arasında değişen, 16’sı kız, 9’u erkek toplam 25 hasta çalışma kapsamına alındı. Uluslararası Romatizma ile Savaş Birliği (ILAR) tanı kriterlerine göre hastalık başlangıç yaşı 16’dan küçük olup, en az 2 yıldır düzenli olarak her 3 ayda bir kontrole gelen 17 oligoartritli, 8 seronegatif poliartritli hasta çalışmaya katıldı. Tüm hastaların yaşı, cinsiyeti, hastalık başlangıç yaşı, hastalık süresi, klinik bulguları hazırlanan forma kaydedildi. HLA doku grupları, tam kan sayımı, akut faz reaktanları (C-Reaktif protein ve Eritrosit sedimentasyon hızı), biyokimyasal verileri, serum immünglobulin değerleri istendi. Ayrıca, hastaların tedaviye verdiği cevaplar Avrupa Romatizma ile Savaş Birliği (EULAR) aktivite kriterlerine göre 3 ayda bir değerlendirildi. Bulgular: HLA doku antijeni taşıma açısından 2 grup kıyaslandığında anlamlı fark vardı. (p

Aim: To evaluate and compare the laboratory data reflecting HLA tissue types and disease activity in follow-up of poliarticular and oligoarticular juvenile idiopathic arthritis (JIA) and to investigate the laboratory data which overlaps best with the disease irresponsive to treatment. Methods: Twenty-five patients (16 girls, 9 boys) with the age range of 3-14 years, followed-up at least 2 years from our pediatric rheumatology policlinic from December 1996 to January 2002 were enrolled. Seventeen was diagnosed as oligoarticular and 8 as seronegative poliarticular JIA according to ILAR (International League of Associations for Rheumatology) criteria and were followed up regularly at three month intervals. Age, gender, age at disease onset, duration of disease and clinical findings were recorded. HLA tissue types, full blood count, acute phase reactants (C-reactive protein and erythrocyte sedimentation rate), biochemical data and serum immunoglobulin levels were investigated. The response to therapy was evaluated every three months according to EULAR (European League Against Rheumatism) disease activity criteria. Results: There was a statistically significant difference between two subtypes in terms of HLA tissue types (p<0.05). HLA-A2 was positive in 41.2 % of the patients with oligoarticular JIA. In both subtypes of JIA, the increase in hemoglobin levels and decrease in leukocyte counts, erythrocyte sedimentation rate and CRP levels (at disease onset and) at 3rd, 6th months and 1st year were statistically significant (p<0.05). When oligoarticular and poliarticular subtypes were compared in terms of laboratory data (values at disease onset, 3rd, 6th, 12th months), there was statistically significant difference in only CRP levels and trombocyte levels at disease onset and 1st year (p<0.05). When the relationship between laboratory data and EULAR activity criteria were investigated; CRP, ESR and thrombocyte values were significantly higher in active and stabile disease group. Conclusion: HLA-A2 tissue type was significantly higher in oligoarticular subtype of JIA. Significant changes were observed during follow-up, in full blood count, CRP and ESR levels reflecting disease activity. The higher CRP and thrombocyte levels in poliarticular JIA, when compared to oligoarticular JIA reflect the severity of inflammation. The laboratory data that overlapped best with active disease irresponsive to treatment were the increase in thrombocyte, CRP and ESR levels