Fatma NARTER, Özlem KETENCİ, Gülnur TOKUÇ, Engin TUTAR, Sedat ÖKTEM

Distal renal tübüler asidozda hiperkalsemi

Beslenme güçlüğü, kusma, kilo alamama, gelişememe yakınmaları, ile getirilen 32 günlük term bir bebekte distal renal tiihiiler asidoza sekonder hiperkalsemi (16.4 mgldL) mevcuttu. Hiperkalsemik devrede alman plazma paratiroid hormon düzeyi (2.7pg/mL) düşük saptandı. Bu vaka ile hiperkalsemik yenidoğanların ayıcı tanısında renal tübüler asidozun da yer alması gerektiği düşünüldü.

Anahtar Kelimeler:

Asidoz, renal tübüler, Hiperkalsemi, Süt çocuğu, yenidoğan, Erkek

Hypercalcemia in distal renal tubular acidosis

We describe a 32 day old full-term baby with hypercalcemia.(16.4 mgldL) and nephrocalcinosis secondary to distal renal tubular acidosis. He was initally seen because of poor feeding, frequent vomiting, failure to thrive. Plasma paratiroid hormone (PTH) level (2.7 pglmL) was very low during the hypercalcemic episode. Distal renal tubular acidosis should be included in the differential diagnosis of hypercalcemia in the neonate.

Keywords:

Acidosis, Renal Tubular, Hypercalcemia, Infant, Newborn, Male,

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1. Hanna JD, Santos F, Ghan JCM. Renal tubular acidosis. In: Kher KK, Mekker SP, (eds). Clinical Pediatric Nephrology, New York: McGraw Hill, 1992: 669-70.
2. Caldas A, Broyer M, Dechaux M. Primary distal tubular acidosis in childhood: Clinical study and long-term follow-up of 28 patients. J Pediatr 1992; 121:233-41.
3. Chan JCM, Scheinman JI, Roth KS. Renal tubular acidosis. Pediatr Rev 2001; 22: 277-85.
4. Rodriguez-Soriano J, Fuentes MG, Vallo A, Alvarez JL. Hypercalcemia in neonatal distal renal tubular acidosis. Pediatr Nephrol 2000; 14: 354-5.
5. Burg FD, Wald ER, Ingelfinger JR, Polin RA. Gellis and Kagan's Current Pediatrics Therapy. 16th ed. Philadelphia: WB SaundersCo, 1999.
6. Üçsel R, Çoban A, Kadıoğlu A, et al. Nephrocalcinosis in the newborn. Acta Pediatr Jpn 1995; 37: 174-6.
7. Miller SG, Schwartz GJ. Hyperammonaemia with distal renal tubular acidosis. Arch Dis Child 1997; 77: 441-4.
8. Cachat F, Froideuaux V, Guignard JP. Renal tubular acidosis in children. Pediatrie 1993; 48: 313-26.
9. Kop WWK, Tsang RC. Calcium and magnesium homeostasis. In: Avery GB, Fletcher MA, MacDonald MG, (eds). Neonato-logy, Philadelphia: Lippincott Williams&Wilkins, 1999: 726-8.
10. Rodriguez-Soriano J. New insights into the patogenesis of renal tubular acidosis from functional to molecular studies. 2000; 14: 1121-36.