1925

SELENYUMUN İNSAN SAĞLIĞI ÜZERİNE ETKİLERİ VE DİYABETES MELLİTUSLA İLİŞKİSİ

Selenyum tiroid hormonu metabolizması, antioksidan savunma ve immün sistemin düzenlenmesi başta olmak üzere vücutta birçok mekanizmada rol alan ve birçok enzime kofaktör olarak katılan esansiyel bir elementtir. Selenyum eksikliğinin yaşlanma, kanser, insülin direnci, diyabet, kardiyovasküler ve nörodejeneratif hastalıklar, artmış mortalite riski, immün sistem hastalıklarıyla ile ilişkili olabileceği belirtilmektedir. Serum selenyum seviyesini istenilen düzeyde tutmak için selenyumdan zengin olan besinler yeterli miktarda diyette yer almalıdır. Selenyumun diyabetes mellitus ile ilişkisinde literatürde çelişkili veriler bulunmakta bu nedenle, mekanizması tam olarak açıklanamamaktadır. Sonuç olarak selenyunum diyabetle ile ilişkisinin hangi düzeyde olduğunun belirlenmesi için daha fazla çalışma yapılması gerekmektedir.

Effects of Selenium on Human Health and its Relationship With Diabetes Mellitus

Selenium is an essential element involved in many mechanisms in the body, especially in thyroid hormone metabolism, antioxidant defense and regulation of the immune system, and involved as a cofactor in many enzymes. It is reported that selenium deficiency might be associated with aging, cancer, insulin resistance, diabetes, cardiovascular and neurodegenerative diseases, increased mortality risk and immune system diseases. To keep serum selenium level at desired levels it should be included in the diet. In the literature, there are contradictory data about the relationship of selenium with diabetes mellitus, therefore the mechanism cannot be fully explained. As a conclusion, more studies need to be for determining the level of association with selenium and diabetes.

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1. Tajaddini MH, Keikha M, Razzazzadeh A, Kelishadi R. A systematic review on the association of serum selenium and metabolic syndrome. J Res Med Sci. 2015;20:782-9.
2. Iglesias P, Selgas R, Romero S, Díez JJ. Selenium and kidney disease. J Nephrol. 2013;26(2):266-72.
3. Roman M, Jitaru P, Barbante C. Selenium biochemistry and its role for human health. Metallomics. 2014;6(1):25-54.
4. Wang X, Wu H, Long Z, Sun Q, Liu J, Liu Y, Hai C. Differential effect of Se on insulin resistance: regulation of adipogenesis and lipolysis. Molecular and Cellular Biochemistry. 2016;415:89-102.
5. Hurst R, Armah CN, Dainty JR, Hart DJ, Teucher B, Goldson AJ, et al. Establishing optimal selenium status: results of a randomized, double-blind, placebo-controlled trial. The American Journal of Clinical Nutrition. 2010;91(4):923-31.
6. Rayman MP. Food-chain selenium and human health: emphasis on intake. British Journal of Nutrition. 2008;100:254-68.
7. Rayman MP. Selenium and human health. Lancet. 2012;379:1256-68.
8. Bal C, Büyükşekerci M, Ercan M, Hocaoğlu A, Çelik HT, Abuşoğlu S, et al. Farklı selenyum seviyelerinin tiroid hormon sentezi üzerine etkisi. Turk Hij Den Biyol Derg. 2015;72(4):311-6.
9. Duntas LH, Benvenga S. Selenium: an element for life. Endocrine. 2015;48:756-75.
10. Xia Y, Hill KE, Li P, Xu J, Zhou D, Motley AK, et al. Optimization of selenoprotein P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement: a placebocontrolled, double-blind study of selenomethionine supplementation in selenium-deficient Chinese subjects. The American Journal of Clinical Nutrition. 2010;92(3):525-31.
11. Hargreaves MK, Liu J, Buchowski MS, Patel KA, Larson CO, Schlundt DG, et al. Plasma selenium biomarkers in low income black and white Americans from the southeastern United States. PloS One. 2014;9(1):e84972.
12. Mueller AS, Mueller K, Wolf NM, Pallauf J. Selenium and diabetes: an enigma?. Free radical research. 2009;43(11):1029-59.
13. Boosalis MG. The role of selenium in chronic disease. Nutrition in Clinical Practice. 2008;23(2):152-60.
14. Rocourt CR, Cheng WH. Selenium supranutrition: are the potential benefits of chemoprevention outweighed by the promotion of diabetes and insulin resistance?. Nutrients. 2013;5(4):1349-65.
15. Türkiye'ye özgü beslenme rehberi. Türkiye için Önerilen Günlük Enerji ve Besin Ögeleri Güvenilir Alım Düzeyleri Ek 1. Beslenme, Hacettepe Üniversitesi, Diyetetik Bölümü ve TC Sağlık Bakanlığı. 2004;59.
16. Türkiye Beslenme Rehberi 2015 (TÜBER).Türkiye için Enerji ve Besin Ögeleri Referans Değerleri Ek 1. (Ed: Başoğu S ve Acar-Tek N.). T.C. Sağlık Bakanlığı Türkiye Halk Sağlığı Kurumu. Kayıhan Ajans, Ankara. 2016;175.
17. Combs GF, Watts JC, Jackson MI, Johnson LK, Zeng H, Scheett AJ, et al. Determinants of selenium status in healthy adults. Nutrition Journal. 2011;10(1):75.
18. Gudmundsdottir EY, Gunnarsdottir I, Thorlacius A, Reykdal O, Gunnlaugsdottir H, Thorsdottir I, et al.. Blood selenium levels and contribution of food groups to selenium intake in adolescent girls in Iceland. Food & nutrition research. 2012;56:18476.
19. Fayet F, Flood V, Petocz P, Samman S. Avoidance of meat and poultry decreases intakes of omega-3 fatty acids, vitamin B12, selenium and zinc in young women. J Hum Nutr Diet. 2014;27(2):135- 42.
20. Jain RB, Choi YS. Normal reference ranges for and variability in the levels of blood manganese and selenium by gender, age, and race/ethnicity for general US population. Journal of Trace Elements in Medicine and Biology. 2015;30:142-52.
21. Giray B, Hıncal F. Selenium status ın Turkey: Possible link between status of selenium, ıodine, antioxidant enzymes and oxidative DNA damage. Journal of Radioanalalytical and Nuclear Chemistry. 2004;259:199-20.
22. https://fnic.nal.usda.gov/food-composition/vitamins-and-minerals/selenium [Erişim Tarihi: 05.07.2016].
23. Galan P, Viteri FE, Bertrais S, Czernichow S, Faure H, Arnaud J, et al. Serum concentrations of ?-carotene, vitamins C and E, zinc and selenium are influenced by sex, age, diet, smoking status, alcohol consumption and corpulence in a general French adult population. European Journal of Clinical Nutrition. 2005;59(10):1181-90.
24. Sánchez C, López-Jurado M, Aranda P, Llopis J. Plasma levels of copper, manganese and selenium in an adult population in southern Spain: Influence of age, obesity and lifestyle factors. Science of the total environment. 2010;408(5):1014-20.
25. Laclaustra M, Navas-Acien A, Stranges S, Ordovas JM, Guallar E. Serum selenium concentrations and diabetes in US adults: National Health and Nutrition Examination Survey (NHANES) 2003-2004. Environmental health perspectives. 2009;117(9):1409-13.
26. Vinceti M, Grill P, Malagoli C, Filippini T, Storani S, Malavolti M, et al. Selenium speciation in human serum and its implications for epidemiologic research: a cross-sectional study. Journal of trace elements in medicine and biology. 2015;31:1-10.
27. Gao H, Hägg S, Sjögren P, Lambert PC, Ingelsson E, Dam RM. Serum selenium in relation to measures of glucose metabolism and incidence of Type 2 diabetes in an older Swedish population. Diabetic medicine. 2014;31(7):787-93.
28. Alasfar F, Ben-Nakhi M, Khoursheed M, Kehinde EO, Alsaleh M. Selenium is significantly depleted among morbidly obese female patients seeking bariatric surgery. Obesity surgery. 2011;21(11):1710- 3.
29. Kim HN, Song SW. Concentrations of chromium, selenium, and copper in the hair of viscerally obese adults are associated with insulin resistance. Biological trace element research. 2014;158(2):152-7.
30. Kilinc M, Coskun A, Bilge F, Imrek SS, Atli Y. Serum reference levels of selenium, zinc and copper in healthy pregnant women at a prenatal screening program in southeastern Mediterranean region of Turkey. Journal of Trace Elements in Medicine and Biology. 2010;24(3):152-6.
31. Spina A, Guallar E, Rayman MP, Tigbe W, Kandala NB, Stranges S. Anthropometric indices and selenium status in British adults: The UK National Diet and Nutrition Survey. Free Radical Biology and Medicine. 2013;65:1315-21.
32. Kut A, Boşkuş Y, Çaycı Ö, Geçkil AÜ. Tip 2 diyabetik hastalarda statin kullanımı ile glisemik kontrol arasında ilişki var mıdır?. Türk Aile Hek Derg. 2015;19(4):179-86.
33. Guariguata L, Whiting DR, Hambleton I, Beagley J, Linnenkamp U, Shaw JE. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract. 2014;103:137-49.
34. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes estimates for the year 2000 and projections for 2030. Diabetes Care 2004;27:1047-53.
35. Guariguata L, Whiting DR, Hambleton I, Beagley J, Linnenkamp U, Shaw JE. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Research and Clinical Practice. 2014;103:137-49.
36. Satman I, Omer B, Tutuncu Y, Kalaca S, Gedik S, Dinccag N, et al. Twelve-year trends in the prevalence and risk factors of diabetes and prediabetes in Turkish adults. European Journal of Epidemiology. 2013;28(2):169-80.
37. Kornhauser C, Garcia-Ramirez JR, Wrobel K, Pérez-Luque EL, Garay-Sevilla ME, Wrobel K. Serum selenium and glutathione peroxidase concentrations in type 2 diabetes mellitus patients. Primary Care Diabetes. 2008;2(2):81-5.
38. Asemi Z, Jamilian M, Mesdaghinia E, Esmaillzadeh A. Effects of selenium supplementation on glucose homeostasis, inflammation, and oxidative stress in gestational diabetes: Randomized, doubleblind, placebo-controlled trial. Nutrition. 2015;31(10):1235-42.
39. Farrokhian A, Bahmani F, Taghizadeh M, Mirhashemi SM, Aarabi MH, Raygan, et al. Selenium supplementation affects ınsulin resistance and serum hs-CRP in patients with type 2 diabetes and coronary heart disease. Hormone and Metabolic Research. 2016;48(04):263-8.
40. Kim CY, Zhu Y, Buhman KK, Kim KH. Dietary selenate attenuates adiposity and improves insulin sensitivity in high-fat diet-induced obese mice. Journal of Functional Foods. 2015;17:33-42.
41. Yerlikaya FH, Toker A, Aribas A. Serum trace elements in obese women with or without diabetes. The Indian Journal of Medical Research. 2013;137(2):339-45.
42. Stranges S, Marshall JR, Natarajan R, Donahue RP, Trevisan M, Combs GF, et al. Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial. Annals of Internal Medicine. 2007;147(4):217-23.
43. Yang SJ, Hwang SY, Choi HY, Yoo HJ, Seo JA, Kim SG, et al. Serum selenoprotein P levels in patients with type 2 diabetes and prediabetes: implications for insulin resistance, inflammation, and atherosclerosis. The Journal of Clinical Endocrinology & Metabolism. 2011;96(8):E1325-9.
44. Misu H, Ishikura K, Kurita S, Takeshita Y, Ota T, Saito Y, et al. Inverse correlation between serum levels of selenoprotein P and adiponectin in patients with type 2 diabetes. PloS One. 2012;7(4):e34952.
45. Arnaud J, Akbaraly NT, Hininger I, Roussel AM, Berr C. Factors associated with longitudinal plasma selenium decline in the elderly: the EVA study. The Journal of Nutritional Biochemistry. 2007;18(7):482-7.
46. Lippman SM, Klein EA, Goodman PJ, Lucia MS, Thompson IM, Ford LG, et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). Jama. 2009;301(1):39-51.
47. Vinceti M, Grioni S, Alber D, Consonni D, Malagoli C, Agnoli C, et al. Toenail selenium and risk of type 2 diabetes: the ORDET cohort study. Journal of Trace Elements in Medicine and Biology. 2015;29:145-50.
48. Mao S, Zhang A, Huang S. Selenium supplementation and the risk of type 2 diabetes mellitus: a meta-analysis of randomized controlled trials. Endocrine. 2014;47(3):758-63.
49. Cominetti C, Bortoli MC, Garrido AB, Cozzolino SM. Brazilian nut consumption improves selenium status and glutathione peroxidase activity and reduces atherogenic risk in obese women. Nutrition Research. 2012;32(6):403-7.
50. Rayman MP, Blundell-Pound G, Pastor-Barriuso R, Guallar E, Steinbrenner H, Stranges S. A randomized trial of selenium supplementation and risk of type-2 diabetes, as assessed by plasma adiponectin. PloS One. 2012;7(9):e45269.