Hülya NAZİK, Selçuk NAZİK, Feride Gül ÇOBAN

NÖTROFİL LENFOSİT VE PLATELET LENFOSİT ORANLARININ AKTİF BEHÇET HASTALARINDAKİ ÖNEMİ

Amaç: Behçet Hastalığı; otoimmun, inflamatuar ve sistemik bir hastalıktır. Hastalığın klasik triadı; oral aft, genital ülser ve üveittir. Bu çalışmanın amacı; C-reaktif protein (CRP), eritrosit sedimentasyon hızı (ESR), nötrofil lenfosit oranı (NLO), platelet lenfosit oranı (PLO), platelet sayısı (PLT) ve ortalama platelet hacmi (MPV) ile sistemik inflamatuar bir hastalık olan Behçet arasındaki ilişkinin ortaya konulması amaçlanmıştır.Yöntemler: Çalışmaya Ocak 2014-Eylül 2015 tarihleri arasında, uluslararası sınıflandırma kriterlerine uygun olarak Behçet Hastalığı tanısı almış 53 hasta ve 55 sağlıklı olgu alındı. Behçet hastaları aktif (n=20) ve inaktif (n=33) olarak iki gruba ayrıldı. CRP, ESR, WBC, PLT, MPV değerleri kaydedildi, NLO ve PLO değerleri hesaplandı.Bulgular: Aktif Behçet'li hastalarda CRP, ESR, WBC, PLT, MPV, NLO ve PLO değerlerinin ölçüldüğü Receiver operating characteristic eğrisi değerlendirmesinde en yüksek AUC değeri CRP'de tespit edilirken (Eğri altındaki alan (AUC):0.964) sonraki AUC değerleri ESR (AUC:0,849), WBC (AUC:0,849), NLO (AUC:0,816), PLO (AUC:0,661), PLT (AUC:0,654) ve MPV (AUC:0,524) olarak gözlenmiştir.Sonuç: Bu sonuçlar; NLO, PLO ve PLT değerlerinin CRP, ESR ve WBC gibi Behçet Hastalığı'nın aktif dönemini öngörmede kullanılabileceği buna karşın MPV'nin kullanılamayacağını ortaya koymaktadır.

The Importance of Neutrophil to Lymphocyte and Platele to Lymphocyte Ratios in Active Behcet Disease

Objective: Behcet Disease; is an autoimmune, inflammatory and systemic diseases. Classic triad of the disease are oral ulcers, genital ulcers and uveitis. The aim of this study is to reveal the relationship between C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), platelet (PLT) and mean platelet volume (MPV) and Behcet which is a systemic inflammatory disease.Methods: Fifty-three patientswho were diagnosed by the international diagnostic criteria of Behcet Disease; and 55 healthy subjects were enrolled in the study, between January 2014 and October 2015. Behcet Disease patients were divided into two groups: active (n=20) and inactive (n=33). CRP, ESR, WBC, PLT, MPV were recorded, NLR and PLR was calculated.Results: An evaluation of the Receiver operating characteristic curves for the CRP, ESR, WBC, PLT, MPV, NLR and PLR value smeasured at active Behcet Disease patients indicated that the CRP value had the highest (Area Under Curve (AUC):0.964), while then exthighest AUC values were observed with ESR (AUC:0,849), WBC (AUC:0,849), NLR (AUC:0,816), PLR (AUC:0,661), PLT (AUC:0,654) and MPV (AUC:0,524).Conclusion: These findings suggest that NLR, PLR and PLT levels can be used to predict the period of active Behcet Disease like CRP, ESR and WBC whereas MPV levels can not be used.

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