Gökhan GÖRGİŞEN

İNSÜLİN DİRENCİNDE İNSÜLİN RESEPTÖR SUBSTRAT 1 (IRS1) PROTEİNİNİN ROLÜ Role of Insulin Receptor Substrate 1 (IRS1) Protein in Insulin Resistance

ISSN: 2146-4006
Yayın Aralığı: 4
Başlangıç: 2015
Yayıncı: Bozok Üniversitesi

İNSÜLİN DİRENCİNDE İNSÜLİN RESEPTÖR SUBSTRAT 1 (IRS1) PROTEİNİNİN ROLÜ

Anahtar Kelimeler:

İNSÜLİN DİRENCİNDE İNSÜLİN RESEPTÖR SUBSTRAT 1 (IRS1) PROTEİNİNİN ROLÜ Role of Insulin Receptor Substrate 1 (IRS1) Protein in Insulin Resistance

ÖZGÜL ÖĞRENME BOZUKLUĞU BULUNAN ÇOCUKLARDA SERUM FOLAT, VİTAMİN B12,HOMOSİSTEİN VE VİTAMİN D SEVİYELERİ Serum Folate, Vitamin B12, Homocysteine and Vitamin D Levels in Children With Specific Learning Disorder

Objective:The aim of the study was to investigate serum folate, vitamin B12, homocysteine and vitamin D levelsof children with specific learning disorder, which is one of the most common psychiatric disorders in childhood period. Material and Methods: 42 children with learning disorders and 30 healthy controls were compared. Serum folate, vitamin B12, homocysteine and vitamin D levels were measured.Results: Folate levels were significantly lower in the patient group compare to the healthy controls (p = 0.046). There were no significant differences between the two groups in terms of vitamin B12 and homocysteine levels (p = 0.059 and p = 0.077 respectively). Vitamin D was significantly lower in the patient group (p <0.001).Conclusion: These results suggest that deficiency or insufficiency of vitamin D, folate and vitamin B12 may be present in children with specific learning disorder, which may contribute to the pathogenesis of the disorder. This study is important because it is the first study to investigate vitamin D, folate and homocysteine related to one carbon metabolism in children with learning disorders.

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