İNSÜLİN DİRENCİNDE İNSÜLİN RESEPTÖR SUBSTRAT 1 (IRS1) PROTEİNİNİN ROLÜ

İnsülin direnci, iskelet kası, yağ ve karaciğer gibi insülinin hedef dokularının hücresel düzeydeinsüline gereken yanıtı verememesi ya da az vermesi durumudur. İnsülin direncinin başta Tip 2 Diyabetolmak üzere birçok hastalığın öncülü olması nedeniyle patogenezinin aydınlatılması oldukçaönem taşımaktadır. İnsülin direncine neden olan moleküler mekanizmalar tam olarak bilinmemektedir.Ancak son yıllarda yapılan çalışmalar, insülin direnci gelişimindeki etkin mekanizmalarınbaşında insülin reseptör substrat (IRS) proteinleri üzerinden gerçekleşen hücre sinyali regülasyonundakibozukluğun olduğunu ortaya koymuştur. Biz bu derlememizde IRS1 proteininin, normalve patolojik durumdaki regülasyonu hakkındaki son gelişmeleri ortaya koyarak, insülin direncioluşum mekanizmalarını aydınlatmaya yönelik yeni çalışmalara öncül olabilmeyi amaçlamaktayız.

Role of Insulin Receptor Substrate 1 (IRS1) Protein in Insulin Resistance

Insulin resistance is defined as the reduced ability of insulin target tissues such as skeletal muscle, adipose and liver to respond properly to insulin actions. Insulin resistance is a precursor of Type 2 diabetes and other pathological conditions. Therefore, determining the pathogenesis of insulin resistance is important. Although molecular mechanisms of insulin resistance is not well-known, most of the studies showed that dysregulation of Insulin Receptor Substrate (IRS) signaling is a common situation that contribute to developing insulin resistance. In this review, we aim to play pioneering role that clarifies the molecular mechanism of insulin resistance by focusing on the recent studies about the normal and pathologic regulations of IRS1 signaling.

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