Mehmet DOKUR, Erdal UYSAL, Mesut SİPAHİ, Mehmet Ali İKİDAĞ, Mehmet SÖKÜCÜ

ERİŞKİN ERKEK MEMESİNDE İNTRADUKTAL KARSİOMLA BİRLİKTELİK GÖSTEREN İNTRAKİSTİK PAPİLLER KARSİNOM: NADİR BİR OLGU

Meme karsinomları erkeklerde daha az görülür. Ayrıca memede intrakistik papiller karsinom ve intraduktal karsinom birlikteliği son derece nadir.İntrakistik papiller karsinometyolojisinde çok sayıda factor suçlanmıştır. İntrakistik papiller karsinomun ultrasonografik bulguları tipiktir. Eksizyonel biyopsi ile beraber mümkünse immunohisto kimyasal boyama yapılması mikroskopik tanı için önemlidir. İntrakistik papiller karsinomların prognozu,intraduktal karsinomlara gore daha iyidir ve invazivolanlarında local yayılım görülür.İntrakistik papiller karsinom tedavisinde invazyon belirtileri varsa, adjuvant kemoterapi ile beraber radikal mastektomi önerilir. Hormono terapinin yararı halen tartışmalıdır.Bu makalede, hastane mizin acil servisine sağ memesinde ağrısız bir kitle ile başvuran 74 yaşındaki bir erkek hastanın klinik bulguları, tanı ve tedavi prensipleri güncel literature ışığında tartışıldı.

Intracystic Papillary Carcinoma in Association with Intraductal Carcinoma in Adult Male Breast: A Rare Case Report

Breast carcinomas are less common in males. Also intracystic papillary carcinoma and intraductal carcinoma are seen together, this is extremely rare in breast in men. Many factors have been implicated in etiology of intracystic papiller carcinoma. Ultrasonographic findings of intracystic papillary carcinoma is typical. It is important to have excisional biopsy and perform immunohistochemical staining-if possible along under microscopy. The prognosis of intracystic papilloma is relatively better than intraductal carcinoma and its spread is mostly local if invasive. In the treatment of intracystic papillary carcinoma, if there are signs of invasions of radical mastectomy with adjuvant radiotherapy treatment is recommended. The benefits of hormone therapy are still controversial.In this article, a 74 year-old male patient who noticed a painless mass in his right breast and incidentally admitted to our emergency department and this patient's clinical findings, diagnosis and treatment principles are discussed in the current literature.

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Akladios CY, Roedlich MN, Bretz-Grenier MF, Croce S, Mathelin C. Intracystic papillary carcinoma of the breast: a diagnostic challenge with major clinical impact Anticancer Res. 2014;34(9):5017-20.
Vagholkar K, Dastoor K, Gopinathan I. Intracystic papillary carcinoma in the male breast: a rare endpoint of a wide spectrum. Case Rep Oncol Med. 2013;2013:129353.
Anderson WF, Devesa SS. In situ male breast carcinoma in the Surveillance, Epidemiology, and End Results database of the National Cancer Institute.Cancer. 2005;104(8):1733-41.
Tsuda H, Uei Y, Fukutomi T, Hirohashi S. Different incidence of loss of heterozygosity on chromosome 16q between intraductal papilloma and intracystic papillary carcinoma of the breast. Jpn J Cancer Res. 1994; 85:992-96.
Muallaoglu S, Ozdemir E, Kutluay L. Intracystic papillary carcinoma of the breast in a male patient: a case report. Case Rep Med. 2012;2012:378157.
Solorzano CC, Middleton LP, Hunt KK, Mirza N, Meric F, Kuerer HM et al. Treatment and outcome of patients with intracystic papillary carcinoma of the breast. Am J Surg. ;184(4):364-8.
Hariprasad P, Srinivas T.Intracystic papillary carcinoma of the breast in males: a case report and review of the literature.JClinDiagn Res. 2013;7(3):568-70.
Wynveen CA, Nehhozina T, Akram M, Hassan M, Norton L, Van Zee KJ, Brogi E. Intracystic papillary carcinoma of the breast: An in situ or invasive tumor? Results of immunohistochemical analysis and clinical follow-up.Am J SurgPathol. 2011;35(1):1-14.
Lam WW, Tang AP, Tse G, Chu WC. Radiology-Pathology conference: papillary carcinoma of the breast. Clin Imaging. ;29(6):396-400.
Olu-Eddo AN, OhanakaCE.Niger Postgrad Med J. Intracystic papillary carcinoma of the breast in a Nigerian male: case report.2008;15(4):270-1.
Stamatakos M, Stefanaki C, Stasinou T, Papantoni E, Alexiou I, Kontzoglou K. Intracystic Papillary Carcinoma of the Breast in Males. In Search of the Optimal Treatment for this Rare Disease. Breast Care (Basel). 2011;6(5):399-403.
Kamyab A, Kasmikha Z, Singhi U, Jacobs MJ. Intracystic papillary carcinoma with associated intraductal carcinoma of the breast in a male. Am Surg. 2011;77(12):E267-8.
Sun Y, Howard-McNatt M. Intracystic papillary carcinoma of the breast in a male patient. Am Surg. 2014;80(3):E84-5. Review.
Ingle SB, Hinge Ingle CR, Murdeshwar HG, Adgaonkar BD. Unusual case of insitu (intracystic) papillary carcinoma of breast. World J Clin Cases. 2013;1(7):227-9.
Wang H, Li F, Luo B. Breast intracystic papillary carcinoma. Breast J. 2011;17(6):676-7.
Fayanju OM, Ritter J, Gillanders WE, Eberlein TJ, Dietz JR, Aft R et al. Therapeutic management of intracystic papillary carcinoma of the breast: the roles of radiation and endocrine therapy. Am J Surg. 2007;194(4):497-500.