Yetişkinlerde Konserve Balık Tüketimine Bağlı Ağır Metal Maruziyet Riskinin Değerlendirilmesi

Amaç: Bu çalışma, Ankara piyasasında satılan 7 farklı türe ait (ton, sardalya, somon, uskumru, hamsi, alabalık ve levrek) 66 adet konserve balığın ağır metal içeriklerini analiz etmek ve yetişkin bireylerin ağır metal maruziyet düzeylerinin saptanarak risk değerlendirmesini yapmak amacıyla planlanmış ve yürütülmüştür. Gereç ve Yöntem: Tüm konserve balık örneklerinin ICP-MS (indüktif eşleşmiş plazma-kütle spektrometresi) cihazında kurşun (Pb), kadmiyum (Cd), alüminyum (Al) ve arsenik (As) analizleri yapılmıştır. Yetişkin bireylerin haftada 2 porsiyon konserve balık tüketmeleri halinde maruz kalacakları Pb, Cd, Al ve As düzeyleri hesaplanmıştır. Bulgular: Analiz edilen balıklar içerisinde Pb ve Cd açısından en yüksek içeriğe sahip olan tür ton balığıdır (sırasıyla; 0.12±0.16 mg/kg, 6.41±4.98 mcg/kg). Alüminyum açısından en yüksek konsantrasyona sahip konserve hamsi iken (1.91±0.15 mg/kg), As açısından en yüksek düzey sardalya da (2.16±1.13 mg/kg) belirlenmiştir. Araştırma sonuçlarına göre yetişkin bireylerde Pb, Cd, Al ve As maruziyetinin Besin ve İlaç İdaresi (FDA) ve Gıda Katkı Maddeleri Ortak FAO/WHO Uzmanlar Komitesi (JECFA) tarafından belirlenen üst limitlerin altında olduğu saptanmıştır. Sonuç ve Öneriler: Günümüzde konserve balıklar ulaşılabilirlik ve tüketim kolaylığı nedeniyle tercih edilmektedir. Ancak taze veya konserve balıklar diyetimizde ağır metaller yönünden de potansiyel bir risk olarak gösterilmektedir. Bu çalışmada, piyasada satılan farklı içeriğe sahip konserve balıkların farklı düzeylerde ağır metal içeriğine sahip olduğu ve yetişkinlerin farklı düzeylerde ağır metale maruz kaldığı saptanmıştır. Piyasada satışa sunulan farklı türde konserve balıkların günlük tüketim miktarlarına göre farklı yaş gruplarındaki bireylerin ağır metal maruziyet riskini değerlendiren çalışma sayısı oldukça azdır. Bu konuda daha kapsamlı çalışmaların yapılması gerekmektedir.

Evaluation of the Heavy Metal Exposure Risk Due to Canned Fish Consumption in Adults

Objective: The aim of this study was to analyze the metals lead (Pb), cadmium (Cd), aluminium (Al) and arsenic (As) in 66 canned fish from 7 different species (ton, sardine, salmon, mackerel, anchovies, trout and perch) sold in Ankara supermarkets and to determine the heavy metal exposure levels of adult individuals depending on consumption of canned fish and make risk assessment. Materials and Methods: Levels of lead (Pb), cadmium (Cd), aluminum (Al) and arsenic (As) of samples were determined using ICP-MS (inductively coupled plasma–mass spectrometry). And the exposure of selected heavy metal levels was calculated that adults would be exposed to if they consume two portions of canned fish per week. Results: The canned tuna which has the highest content in terms of Pb and Cd among the analyzed fish (0.12±0.16 mg/kg, 6.41±4.98 mcg/kg, respectively). While the highest concentration canned anchovy (1.91±0.15 mg/kg) in terms of Al, the highest concentration of As was also determined in canned sardines (2.16±1.13 mg/kg). According to the findings, it was determined that the exposure of Pb, Cd, Al and As in adult individuals was below the upper limits set by Food and Drug Administration (FDA) and Joint FAO/WHO Expert Committee on Food Additives (JECFA). Conclusion: At the present time, canned fish are preferred due to their accessibility and ease of consumption. However, fresh or canned fish are also shown as a potential risk for heavy metals in our diet. In this study, it has been determined that canned fish with different content sold in the market have different levels of heavy metal content and adults are exposed to different levels of heavy metal. The number of studies assessing the heavy metal exposure risk of individuals for different age groups according to the amount of daily consumption of different types of canned fish is very scarce. Further studies are required.

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  • 1. Rehman K, Fatima F, Waheed I, Akash MSH. Prevalence of exposure of heavy metals and their impact on health consequences. J Cell Biochem. 2018;119(1):157-84.
  • 2. Joint FAO/WHO Food Standards Programme (Codex Alimentarius) Commission: Procedural Manual 21st Edition, Rome: World Health Organization, Food and Agriculture Organization of the United Nations; 2013. 214 p.
  • 3. Hosseini SV, Sobhanardakani S, Miandare HK, Harsij M, Regenstein JM. Determination of toxic (Pb, Cd) and essential (Zn, Mn) metals in canned tuna fish produced in Iran. J Environ Health Sci Eng. 2015;13:59.
  • 4. Flora G, Gupta D, Tiwari A. Toxicity of lead: a review with recent updates. Interdiscip Toxicol. 2012;5(2):47- 58.
  • 5. Obeng-Gyasi E. Sources of lead exposure in various countries. Rev Environ Health. 2019;34(1):25-34.
  • 6. Agency for Toxic Substances & Disease Registry (ATSDR). Toxicological profile for lead. United States Department of Health and Human Services. 2007;1:582.
  • 7. Soylemez E, Kayaalti Z. Toxic effect of lead exposure to newborn and children. The Turkish Journal of Occupational/Environmental Medicine and Safety. 2017;2(1):296-296.
  • 8. Jaishankar M, Tseten T, Anbalagan N, Mathew BB, Beeregowda KN. Toxicity, mechanism and health effects of some heavy metals. Interdiscip toxicol. 2014;7(2):60- 72.
  • 9. Faroon O, Ashizawa A, Wright S, Tucker P, Jenkins K, Ingerman L, et al. Toxicological profile for Cadmium. Atlanta (GA): Agency for Toxic Substances and Disease Registry (ATSDR); 2012.p 1-487.
  • 10. Ertl K, Goessler W. Aluminium in foodstuff and the influence of aluminium foil used for food preparation or short time storage. Food Addit Contam Part B. 2018;11(2):153-9.
  • 11. Ma N, Liu ZP, Yang DJ, Liang J, Zhu, JH, Xu HB, et al. Risk assessment of dietary exposure to aluminium in the Chinese population. Food Addit Contam Part A. 2016;33(10):1557-62.
  • 12. U.S. Department of Health and Human Servıces Public Health Service Agency for Toxic Substances & Disease Registry (ATSDR). Toxicological profile for arsenic, ATSDR; 2007. p 1-20.
  • 13. International Agency for Research on Cancer (IARC). Arsenic, metals, fibres and dusts volume 100C. IARC Monogr Eval Carcinog Risks Hum. 2012. Available at: https://monographs.iarc.fr/wp-content/uploads/2018/06/ mono100C.pdf Accessed: February 8, 2020.
  • 14. Uneyama C, Toda M, Yamamoto M, Morikawa K. Arsenic in various foods: cumulative data. Food Addit Contam. 2007;24(5):447-534.
  • 15. Kakkar P, Jaffery FN. Biological markers for metal toxicity. Environ Toxicol Pharmacol. 2005;19(2):335-49.
  • 16. Türkiye Beslenme ve Sağlık Araştırması 2010 Beslenme Durumu ve Alışkanlıklarının Değerlendirilmesi Sonuç Raporu. Sağlık Araştırmaları Genel Müdürlüğü, Sağlık Bakanlığı. Erişim: https://hsgm.saglik.gov.tr/depo/ birimler/saglikli-beslenme-hareketli-hayat-db/Yayinlar/ kitaplar/diger-kitaplar/TBSA-Beslenme-Yayini.pdf Erişim Tarihi: 16 Temmuz 2020.
  • 17. Anishchenko OV, Sushchik NN, Makhutova ON, Kalachova GS, Gribovskaya IV, Morgun VN, et al. Benefit-risk ratio of canned pacific saury (Cololabis saira) intake: Essential fatty acids vs. heavy metals. Food Chem Toxicol. 2017;101(Supplement C):8-14
  • 18. Yi Y, Tang C, Yi T, Yang Z, Zhang S. Health risk assessment of heavy metals in fish and accumulation patterns in food web in the upper Yangtze River, China. Ecotoxicol Environ Saf. 2017;145(Supplement C):295-302.
  • 19. Joint FAO/WHO Expert Committee on Food Additives (JECFA). Meeting & World Health Organization. Evaluation of Certain Food Additives: Seventy-seventh Report of the Joint FAO/WHO Expert Committee on Food Additives, Italy: World Health Organization; 2013. p.86. Technical Report Series 983.
  • 20. Joint FAO/WHO Expert Committee on Food Additives (JECFA). Meeting & World Health Organization. Evaluation of Certain Food Additives: Seventy-fourth Report of the Joint FAO/WHO Expert Committee on Food Additives, Italy: World Health Organization; 2011. p.148. Technical Report Series 966.
  • 21. Food and Drug Administration. Lead in Food, Foodwares and Dietary Supplements. 2019. Available at: https:// www.fda.gov/food/metals/lead-food-foodwares-anddietary- supplements Accessed February 8, 2020.
  • 22. Joint FAO/WHO Expert Committee on Food Additives (JECFA). Meeting & World Health Organization. Evaluation of Certain Contaminants in Food: Seventysecond report of the JECFA, Italy: World Health Organization; 2010. p.115. Technical Report Series 959.
  • 23. T.C. Sağlık Bakanlığı,Türkiye Beslenme Rehberi (TÜBER). 2015. T.C. Sağlık Bakanlığı Yayın No: 1031, Ankara 2016. 24. Hayran M, Hayran M. Sağlık Araştırmaları İçin Temel İstatistik. 1. Baskı. Ankara: Omega Araştırma; 2011. 49- 84 s.
  • 25. Pastorelli A, Baldini M, Stacchini P, Baldini G, Morelli S, Sagratella E, et al. Human exposure to lead, cadmium and mercury through fish and seafood product consumption in Italy: a pilot evaluation. Food Addit Contam: Part A. 2012;29(12):1913-21.
  • 26. Mol S. Levels of selected trace metals in canned tuna fish produced in Turkey. Journal of Food Composit Anal. 2011;24(1):66-9.
  • 27. Mol S. Determination of trace metals in canned anchovies and canned rainbow trouts. Food Chem Toxicol. 2011;49(2):348-51.
  • 28. Mol S. Levels of heavy metals in canned bonito, sardines, and mackerel produced in Turkey. Biol Trace Elem Res. 2011;143(2):974-82.
  • 29. Tuzen M, Soylak M. Determination of trace metals in canned fish marketed in Turkey. Food Chem. 2007;101(4):1378-82.
  • 30. International Agency for Research on Cancer (IARC). List of Classifications Agents classified by the IARC Monographs, Volumes 1–124. 2006. Available at: https:// monographs.iarc.fr/list-of-classifications Accessed February 8, 2020.
  • 31. Popovic AR, Djinovic-Stojanovic JM, Djordjevic DS, Relic DJ, Vranic DV, Milijasevic MP, et al. Levels of toxic elements in canned fish from the Serbian markets and their health risks assessment. J Food Compost Anal. 2018;67:70-6.
  • 32. Massadeh AM, Allah A, Al-Massaedh T, Kharibeh S. Determination of selected elements in canned food sold in Jordan markets. Environ Sci Pollut Res. 2018;25(4):3501-9.
  • 33. Iwegbue CM. Metal concentrations in selected brands of canned fish in Nigeria: estimation of dietary intakes and target hazard quotients. Environ Monit Assess. 2015;187(3):85.
  • 34. International Agency for Research on Cancer. Cadmium and cadmium compounds. IARC Monographs-100C. 2018. Available at: https://monographs.iarc.fr/wpcontent/ uploads/2018/06/mono100C-8.pdf Accessed February 8, 2020.
  • 35. Novakov NJ, Mihaljev ZA, Kartalovic BD, Blagojevic BJ, Petrovic JM, Cirkovic MA, et al. Heavy metals and PAHs in canned fish supplies on the Serbian market. Food Addit Contam Part B Surveill. 2017;10(3):208-15.
  • 36. Usydus Z, Szlinder-Richert J, Polak-Juszczak L, Kanderska J, Adamczyk M, Malesa-Ciecwierz M, et al. Food of marine origin: between benefits and potential risks. Part I. Canned fish on the Polish market. Food Chem. 2008;111(3):556-63.
  • 37. Kaňa A, Koplík R, Braeuer S, Goessler W, Mestek O. Analysis of main arsenic species in canned fish marketed in the Czech Republic and Austria. J Food Chem Nanotechol. 2018;4(1):10-7.
  • 38. Rahmani J, Fakhri Y, Shahsavani A, Bahmani Z, Urbina MA, Chirumbolo S, et al. A systematic review and metaanalysis of metal concentrations in canned tuna fish in Iran and human health risk assessment. Food Chem Toxicol. 2018;118:753-65.