Evrim KAHRAMANOĞLU AKSOY, Zeynep GÖKTAŞ, Özgür ALBUZ, Muhammet Yener AKPINAR, Doğan ÖZTÜRK, Hakan BULUŞ, Metin UZMAN

Sleeve Gastrektomi Uygulanan Hastalarda Ağırlık Kaybının Nonalkolik Yağlı Karaciğer ile İlgili Bazı Yeni Parametreler Üzerine Etkisi

Amaç: Morbid obez hastalarda bariatrik cerrahinin nonalkolik yağlı karaciğer hastalığı (NAYKH)’nın hem histolojik hem de karaciğer enzimleri üzerine olumlu etkisi olduğu bilinmektedir. Bu çalışmanın amacı sleeve gastrektominin morbid obez hastalarda NAYKH ile ilgili bazı parametreler üzerine etkilerini incelemektir. Bireyler ve Yöntem: Ocak 2017-Ocak 2018 tarihleri arasında sleeve gastrektomi ameliyatı yapılan 70 hasta çalışmaya dahil edilmiştir. Ameliyat öncesi ve ameliyatın 12. ayındaki laboratuvar parametreleri ve antropometrik ölçümleri hasta dosya arşivinden kaydedilmiştir. Hastaların beden kütle indeksi (BKİ), gamaglutamiltransferaz-platelet oranı (GPR), mutlak nötrofil sayısı/mutlak lenfosit sayısı (NLR), mutlak platelet sayısı/mutlak lenfosit sayısı (PLR), mutlak monosit sayısının yüksek dansiteli lipoprotein (HDL)’e oranı (MHR), HOMA-IR, karaciğer enzimleri, toplam ağırlık kaybı (TWL) ve aşırı ağırlık kaybı (EWL) hesaplanmıştır. Bulgular: Hastaların BKİ, HOMA-IR, karaciğer enzimleri, GPR, NLR, MHR değerlerinde 12. ayda anlamlı düşüş izlenirken, PLR değeri açısından fark saptanmamıştır. TWL, EWL ve NAYKH parametreleri arasında korelasyon belirlenmemiştir. Sonuç: Sleeve gastrektomi ameliyatı olmuş NAYKH hastalarının izleminde takibinde GPR, MHR, NLR kullanılabilecek basit parametrelerdir.

The Effect of Weight Loss on Novel Parameters of Nonalcoholic Fatty Liver Disease Undergoing Sleeve Gastrectomy

Aim: In morbid obese patients bariatric surgeries seem to have positive effects on nonalcoholic fatty liver disease (NAFLD) both histologically and enzymatically. Purpose of this study was to evaluate the effects of sleeve gastrectomy on NAFLD related parameters in morbid obese patients.Subjects and Method: A total of 70 patients who underwent sleeve gastrectomy surgery, were included in the study. Laboratory parameters and anthropometric measurements before and 12 months after the surgery were recorded from the hospital records. Body mass index (BMI), gamma-glutamyl transpeptidase-to-platelet ratio (GPR), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte count to high-density lipoprotein (HDL) cholesterol ratio (MHR), HOMAIR, liver enzymes, total weight loss (TWL), and excess weight loss (EWL) of patients were calculated. Results: While there were significant decrease in BMI, HOMA-IR, liver enzymes, GPR, NLR, and MHR levels at the 12th month, PLR levels did not show any difference. There were no correlations between TWL, EWL and NAFLD parameters. Conclusion: GPR, MHR, NLR are the simple parameters that can be used in the follow-up of NAFLD patients who underwent sleeve gastrectomy.

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