NESLİ ERSOY, AYLİN AÇIKGÖZ, Taner ÖZGÜRTAŞ

Probiyotikler ve Yara İyileşme Sürecine Etkileri: Anjiyogenez Üzerine Etki Mekanizması

Probiyotikler, gastrointestinal sistem hastalıklarından depresyona kadar çok sayıda hastalık grubunda çalışılmış ve bu hastalıklar üzerinde probiyotiklerin olumlu etkiler gösterebildiği bildirilmiştir. Probiyotiklerin bildirilen olumlu etkilerini, hastalık gelişimi ve tedavi sürecinde canlı mikrobiyotasını zenginleştirerek gerçekleştirdiği düşünülmektedir. Yara iyileşmesi ise birçok farklı mekanizmanın etkisi altında bulunan bir süreçtir. Bakterilerin bu süreçte yararlı etkileri olduğu gibi farklı bakteri türlerine bağlı olarak olumsuz etkileri de olabilmektedir. Son yapılan çalışmalarda bazı probiyotik bakteri türlerinin topikal uygulaması ya da sistemik etkileri ile yara iyileşmesi üzerinde etkili olduğu saptanmıştır. Özellikle gastrik ülserler üzerinde yapılan çalışmalarda probiyotik bakterilerin antibiyotikler ile karşılaştırıldığında, antibiyotik direncinin olduğu durumlarda anjiyogenez üzerinden etki ederek daha etkili sonuçlar gösterdiği belirtilmiştir. Probiyotiklerin etki mekanizmaları ve hangi bakteri türlerinin etkin olduğuna dair daha fazla çalışma yapılması gerekmektedir.

Probiotics and Their Effects on Wound Healing: The Effect Mechanisms on Angiogenesis

Probiotics have been studied in a large number of disease groups from gastrointestinal system disorders to depression, and it has been reported that they may have positive effects in the aforementioned diseases. The reported positive effects of probiotics are thought to be achieved by enriching the living microbiota during disease development and treatment. Wound healing is a process that is under the influence of many different mechanisms. Bacteria may have beneficial or adverse effects in this process according to their species. Recent studies have shown that some probiotic bacterial strains are effective on wound healing with topical application or by their systemic effects. It has been reported that probiotic bacteria are more effective than antibiotics, particularly in gastric ulcers with antibiotic resistance, by their actions on angiogenesis. Further studies are needed to determine the mechanisms of effect of probiotics and which species of bacteria are effective.

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1. Singh PK, Kaur IP. Synbiotic (probiotic and ginger extract) loaded floating beads: a novel therapeutic option in an experimental paradigm of gastric ulcer. J Pharm Pharmacol 2012;64(2):207-17.
2. Cerdá B, Pérez M, Pérez-Santiago JD, Tornero-Aguilera JF, González-Soltero R, Larrosa M. Gut microbiota modification: another piece in the puzzle of the benefits of physical exercise in health? Front Physiol 2016;7:51.
3. Kerry RG, Patra JK, Gouda S, Park Y, Shin H-S, Das G. Benefaction of probiotics for human health: A review. J Food Drug Anal 2018.
4. Caramia G, Atzei A, Fanos V. Probiotics and the skin. Clin Dermatol 2008;26(1):4-11.
5. Scales BS, Huffnagle GB. The microbiome in wound repair and tissue fibrosis. J Pathol 2013;229(2):323-31.
6. Counsell K. How diet, exercise, and probiotics influence diversity in gut microbiota. Big Sky Undergrad J 2015;3(1):8.
7. Elliott SN, Buret A, McKnight W, Miller MJ, Wallace JL. Bacteria rapidly colonize and modulate healing of gastric ulcers in rats. Am J Physiol Gastrointest Liver Physiol 1998;275(3):G425-G32.
8. Krutmann J. Pre-and probiotics for human skin. Clin Plast Surg 2012;39(1):59-64.
9. El-Ghazely M, Mahmoud W, Atia M, Eldip E. Effect of probiotic administration in the therapy of pediatric thermal burn. Ann Burns Fire Disasters 2016;29(4):268.
10. Dharmani P, De Simone C, Chadee K. The probiotic mixture VSL# 3 accelerates gastric ulcer healing by stimulating vascular endothelial growth factor. PLoS One 2013;8(3):e58671.
11. 11. Lam EK, Yu L, Wong HP, Wu WK, Shin VY, Tai EK, et al. Probiotic Lactobacillus rhamnosus GG enhances gastric ulcer healing in rats. Eur J Pharmacol 2007;565(1- 3):171-9.
12. Giorgetti G, Brandimarte G, Fabiocchi F, Ricci S, Flamini P, Sandri G, et al. Interactions between innate immunity, microbiota, and probiotics. J Immunol Res 2015;2015:501361.
13. Halper J, Leshin L, Lewis S, Li W. Wound healing and angiogenic properties of supernatants from Lactobacillus cultures. Exp Biol Med 2003;228(11):1329- 37.
14. Nasrabadi H, Ebrahimi T. Comparison of the effects of Lactobacillus brevis and Lactobacillus plantarum on cutaneous wound healing in rats. Afr J Microbiol Res 2011;5(24):4226-33.
15. Peral MC, Huaman Martinez MA, Valdez JC. Bacteriotherapy with Lactobacillus plantarum in burns. Int Wound J 2009;6(1):73-81.
16. Khoder G, Al‑Menhali AA, Al‑Yassir F, Karam SM. Potential role of probiotics in the management of gastric ulcer. Exp Ther Med 2016;12(1):3-17.
17. Girard P, Coppé MC, Pansart Y, Gillardin JM. Gastroprotective effect of Saccharomyces boulardii in a rat model of ibuprofen-induced gastric ulcer. Pharmacol 2010;85(3):188-93.
18. Singh PK, Deol PK, Kaur IP. Entrapment of Lactobacillus acidophilus into alginate beads for the effective treatment of cold restraint stress induced gastric ulcer. Food Funct 2012;3(1):83-90.
19. Tsiouris CG, Kelesi M, Vasilopoulos G, Kalemikerakis I, Papageorgiou EG. The efficacy of probiotics as pharmacological treatment of cutaneous wounds: Metaanalysis of animal studies. Eur J Pharm Sci 2017;104:230- 9.
20. Tsiouris CG, Tsiouri MG. Human microflora, probiotics and wound healing. Wound Med 2017;19:33-8.
21. Kapil V, Haydar SM, Pearl V, Lundberg JO, Weitzberg E, Ahluwalia A. Physiological role for nitrate-reducing oral bacteria in blood pressure control. Free Radic Biol Med 2013;55:93-100.22. Ürün bilgisi. Erişim Adresi: https://www.nblprobiotic. com/. Erişim Tarihi: 30.07.2018.
23. Ürün bilgisi. Erişim Adresi: https://www.solgar.com.tr/. Erişim Tarihi: 30.07.2018.
24. Ürün bilgisi. Erişim Adresi: https://www.anti.com.tr/ urunler/bactovis-probiyotik. Erişim Tarihi: 30.07.2018.