Kısa Barsak Sendromunda Beslenme Desteği

Kısa barsak sendromu (KBS), ince barsak rezeksiyonu sonrası gelişen malabsorbsiyon, malnütrisyon, diyare, steatore, ağırlık kaybı, elektrolit ve sıvı kaybı ile karakterize klinik bir tablodur. Hastalığın seyri ve tedavisi geride kalan barsak segmentinin uzunluğundan çok adaptasyonuna bağlıdır ve bu süreç diyarenin kontrolünü gerektirir. Barsak adaptasyonunun sağlanmasında enteral beslenme(EB) büyük önem taşır. Hastalığın ilk evrelerinde total parenteral beslenmeye (TPB) bağımlı olan hastanın erken dönemde EBye geçmesi sağlanmalıdır. Hastaların bir kısmı EByi takiben normal beslenmelerine yakın bir beslenme programına geçebilse de bir kısmı ömür boyu TPBye bağımlı kalabilmektedir. Uzun dönem TPBnin komplikasyonları tedaviyi daha da zorlaştırmaktadır. Nutrisyonel tedavi amaçlı bazı özel ajanların hastalık üzerine etkileri halen araştırılmaktadır. Hastalığın tedavisi uzun bir dönemi kapsamaktadır ve multidisipliner yaklaşım gerektirmektedir.

Nutrition Support in Short Bowel Syndrome

Short bowel syndrome (SBS) is a clinical case which is characterized with, malabsorption, malnutrition, diarrhea, steatore, weight loss, fluid and electrolyte loss, which develops after small intestine resection. The progress and treatment of the disease depends on the adaptation of the remaining intestine rather than the length of the remaining intestine segment, and this process requires the control of diarrhea. To provide intestinal adaptation, enteral nutrition has great importance. During the early stages of the disease, the patients who are dependent on total parenteral nutrition (TPN) should be helped to start to early EN. Even though some of the patient can pass to a nutrition program which is very close to normal nutrition after EN, some other part of the patients may remain dependent on TPN during their life-long. Long-term complications of TPN makes the treatment more difficult. The effects of some specific nutritional agents on the disease are currently under investigation. The treatment of the disease involves a long time period and requires a multidisciplinary approach.

___

  • 1.Tilg H. Short bowel syndrome: searching for the proper diet. Eur J Gastroenterol Hepatol 2008;20:1061-1063.
  • 2.Miyasaka EA, Brown PI, Kadoura S, Harris MB, Teitelbaum DH. The adolescent child with short bowel syndrome: new onset of failure to thrive and need for increased nutritional supplementation. J Pediatr Surg 2010;45:1280-1286.
  • 3.Welters CFM, Dejong CHC, Deutz NEP, Heineman E. Intestinal adaptation in short bowel syndrome. Anz J Surg 2002;72: 229–36
  • 4.Haxhija EQ, Yang H, Spencer AU, Sun X, Teitelbaum DH. Intestinal epithelial cell proliferation is dependent on the site of massive small bowel resection. Pediatr Surg Int 2007;23:379-390.
  • 5.Jiang HP, Chen T, Yan GR, Chen D. Differential protein expression during colonic adaptation in ultra-short bowel rats. World J Gastroenterol 2011;17(20):2572-2579.
  • 6.Olieman JF, Penning C, Ijsselstijn H, Escher JC, Joosten KF, Hulst JM, et al. Enteral nutrition in children with short- bowel syndrome: current evidence and recommendations for the clinician. J Am Diet Assoc 2010;110:420-426.
  • 7.Aydoğan T, Türkay C. Kısa barsak sendromu’nda nutrisyon. Güncel Gastroenteroloji 2011;15(2):127-131.
  • 8.Başoğlu M, Atamanalp S. Kısa bağırsak sendromunda beslenme. Türkiye Klinikleri J Surg Med Sci 2007;3(18):68- 72.
  • 9.Ferreira IML, Braga CBM, Dewulf NLS, Marchini JS, Cunda SFC. Vitamin serum level variations between cycles of intermittent parenteral nutrition in adult patients with short bowel syndrome. J Parenter Enteral Nutr 2012 Mar 27 [E-pub ahead of print], doi:10.1177/0148607112441800.
  • 10.Topgül K, Güngör BB, Anadol AZ, Kesim M. Kısa barsak sendromu. F.Ü. Sağlık Bil. Dergisi 2004;18(3):191-198.
  • 11.Vanderhoof JA, Young RJ. Enteral and parenteral nutrition in the care of patients with short-bowel syndrome. Best Prac Res Clin Gastroenterol 2003;17:997-1015.
  • 12.Thompson JS. Management of short bowel syndrome, In: John L. Cameron editor. Current Surgical Therapy 9th ed. Philadelphia: Mosby; 2008. p. 145-68.
  • 13.Lange S, Boseaus I, Jennische E, Johansson E, Lundgren BK, Lönnroth I. Food- induced antisecretory factor activity is correlated with small bowel length in patients with intestinal resections. APMIS Acta Pathol Microbiol Immunol Scand 2003;111:985-988.
  • 14.Donohoe CL, Reynolds JV. Short bowel syndrome. Surgeon. 2010;8(5):270-279.
  • 15.Sukhotnik I, Shany A, Bashenko Y, Hayari L, Chemodanov E, Mogilner J, et al. Parenteral but not enteral omega-3 fatty acids (Omegaven) modulate intestinal regrowth after massive small bowel resection in rats. J Parenter Enteral Nutr 2010;34(5):503-512.
  • 16.Thompson JS, Rochling FA, Weseman RA, Mercer DF. Current management of short bowel syndrome. Curr Probl Surg 2012;49(2):52-115.
  • 17.Thompson JS, Weseman R, Rochling FA, Mercer DF. Current management of the short bowel syndrome. Surg Clin N Am 2011;91:493-510.
  • 18.Jeppesen PB. Growth factors in short-bowel syndrome patients. Gastroenterol Clin N Am 2007; 36:109-121.
  • 19.Uygun A, Saka M. Spesifik gastrointestinal sistem hastalıklarında beslenme. Güncel Gastroenteroloji 2005;9(2):145-55.
  • 20.Matares LE, Steiger E. Dietary and medical management of short bowel syndrome in adult patients. J Clin Gastroenterol 2006;40:85-93.
  • 21.Sudan D, Di Baise J, Torres C, Thompson J, Raynor S, Gilroy R, et al. A multidisciplinary approach to the treatment of intestinal failure. J Gastrointestinal Surg 2005;9(2):165-176.
  • 22.Tekin A, Yemiş M, Küçükkartallar T, Vatansever C, Çakır M, Yılmaz H, et al. The effects of oral liquid and intravenous glutamine on bowel adaptation in a rabbit short bowel syndrome model. Turk J Gastroenterol 2010;21(3):236-243.
  • 23.Wales PW, Nasr A, deSilva N, Yamada J. Human growth hormone and glutamine for patients with short bowel syndrome. Cochrane Database Syst Rev 2010;6:CD006321.
  • 24.Guo M, Li Y, Li J. Role of growth hormone, glutamine and enteral nutrition in pediatric short bowel syndrome: a pilot follow-up study. Eur J Pediatr Surg 2012;22:121-126.
  • 25.Sigalet DL, Martin GR, Butzner JD, Buret A, Meddings JB. A pilot study of the use of epidermal growth factor in pediatric short bowel syndrome. J Pediatr Surg 2005;40:763-768.
  • 26.Jeppesen PB, Gilroy R, Pertkiewicz M, Allard JP, Messing B, O’Keefe SJ. Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome. Gut 2011;60:902-914.
  • 27.Jeppesen PB, Lund P, Gottschalck IB, Nielsen HB, Holst JJ, Mortensen J, et al. Short bowel patients treated for 2 years with glucagon-like peptide 2 (GLP-2): Compliance, safety and effects on quality of life. Gastroenterol Res Pract 2009;2009:425759.
  • 28.Yazbeck R, Abbott CA, Howarth GS. The use of GLP-2 and related growth factors in intestinal diseases. Curr Opin Investig Drugs 2010;11:440-446.
  • 29.Rowland KJ, Brubaker PL. Life in the crypt: a role for glucagon-like peptide-2? Mol Cell Endocrinol 2008;288:63-70.
  • 30.Rowland KJ, Brubaker PL. The “cryptic” mechanism of action of glucagon-like peptide-2. Am J Physiol Gastrointest Liver Physiol 2011;301:G1-G8.
  • 31.Jeppesen PB, Lund P, Gottschalck IB, Nielsen HB, Holst JJ, Mortensen J, et al. Short bowel patients treated for two years with glucagon-like Peptide 2: effects on intestinal morphology and absorption, renal function, bone and body composition, and muscle function. Gastroenterol Res Pract 2009;2009:616054.
  • 32.Koopmann MC, Chen X, Holst JJ, Ney DM. Sustained glucagon-like peptide-2 infusion is required for intestinal adaptation, and cessation reverses increased cellularity in rats with intestinal failure. Am J Physiol Gastrointest Liver Physiol 2010;299:1222-1230.
  • 33.Liu X, Nelson DW, Holst JJ, Ney DM. Synergistic effect of supplemental enteral nutrients and exogenous glucagon- like peptide 2 on intestinal adaptation in a rat model of short bowel syndrome. Am J Clin Nutr 2006;84:1142-1150.
  • 34.Compher C, Gilroy R, Pertkiewicz M, Ziegler TR, Ratcliffe SJ, Joly F, et al. Maintenance of parenteral nutrition volume reduction, without weight loss, after stopping teduglutide in a subset of patients with short bowel syndrome. J Parenter Enteral Nutr 2011;35:603-609.
  • 35.Seetharam P, Rodrigues G. Short bowel syndrome: a review of management options. Saudi J Gastroenterol 2011;17:229-235.
  • 36.Washizawa N, Gu L H, Gu L, Openo K P, Jones D P, Ziegler T R. Comparative effects of glucagon-like peptide- 2 (GLP- 2), growth hormone (GH), and keratinocyte growth factor (KGF) on markers of gut adaptation after massive small bowel resection in rats. JPEN J Parenter Enteral Nutr. 2004; 28: 399- 409.
  • 37.Akbaba S, Isik S, Ozogul Y, Bostancı EB, Aydog G, Ozdemir M, et al. Effects of melatonin on bacterial translocation in an experimental short bowel syndrome. Afr J Microbiol Res. 2012;6(5):982-990.
  • 38.Lund P, Sangild PT, Aunsholt L, Hartmann B, Holst JJ, Mortensen J, et al. Randomised controlled trial of colostrum to improve intestinal function in patients with short bowel syndrome. Eur J Clin Nutr 2012;66:1059-1065.
  • 39.Dodge ME, Bertolo RF, Brunton JA. Enteral feeding induces early intestinal adaptation in a paranterally fed neonatal piglet model of short bowel syndrome. J Parenter Enteral Nutr 2012;36:205-212.
  • 40.Westergaard H. Short Bowel Syndrome. In: Feldman M, Scharschmidt BF. Sleisenger MH editors. Sleisenger & Fordtran’s Gastrointestinal and Liver Disease Vol.2 8th ed. Philadelphia: Saunders; 2006. p. 2257-75.
  • 41.Amiot A, Messing B, Corcos O, Panis Y, Joly F. Determinants of home parenteral nutrition dependence and survival of 268 patients with non-malignant short bowel syndrome. Clin Nutr 2012 [E-pub ahead of print], doi: 10.1016/j.clnu.2012.08.007.
  • 42.Bozkurt N, Yıldız E. Sindirim Sistemi Hastalıklarında Beslenme. In: Baysal A, Aksoy M, Besler HT, Bozkurt N, Keçecioğlu S, Merdol TK, et al. editors. Diyet El Kitabı. 5. Baskı. Ankara: Hatiboğlu Yayınevi; 2008. p.143-78.
  • 43.Goulet O, Ruemmele F, Lacaille F, Colomb V. Irreversible intestinal failure. JPGN 2004; 38:250-269.
  • 44.Borges VC, Silva LT, Dias CG, Gonzales C, Waitzberg DL. Long-term nutritional assessment of patients with severe short bowel syndrome managed with home enteral nutrition and oral intake. Nutr Hosp 2011;26:832-842.
  • 45.Scolapio JS. Nutritional Disorders & Their Treatment in Diseases of the Gastrointestinal Tract. In: Friedman LS, Mc Quaid RK, Grendell JH, editors. Current Diagnosis & Treatment in Gastroenterology. 2nd edition. USA: R.R.Donnelley and Sons Company; 2003. p. 192-200.
  • 46.Thompson JS, Weseman R, Rochling FA, Mercer DF. Current management of the short bowel syndrome. Surg Clin North Am 2011;91:493-510.
  • 47.Bongaerts GP, Severijnen RS. Arguments for a lower carbohydrate-higher fat diet in patients with a short small bowel. Med Hypotheses 2006;67: 280-282.
  • 48.Pagoldh M, Eriksson A, Heimtun E, Kvifors E, Sternby B, Blomquist L, et al. Effects of supplementary diet with specially processed cereals in patients with bowel syndrome. Eur J Gastroenterol Hepatol 2008;20:1085- 1093.
  • 49.Atia A, Girard-Pipau F, Hebuterne X, Spies WG, Guardiola A, Ahn CW, et al. Macronutrient absorption characteristics in humans with short bowel syndrome and jejunocolonic anastomosis: starch is the most important carbohydrate substrate, although pectin supplementation may modestly enhance short chain fatty acid production and fluid absorption. J Parenter Enteral Nutr 2011;35:229-240.