D Vitamini ve Meme Kanseri

Son yıllarda yapılan çalışmalar, hormon benzeri etki eden D vitamininin kemik metabolizması dışında diğer organların işlevlerinde de önemli rol oynadığını göstermekte ve birçok hastalıkla olan ilişkisi üzerinde yoğunlaşmaktadır. Kanser, otoimmun hastalıklar ve kardiyovasküler hastalıklar gibi bazı hastalıkların gelişimi ile D vitamini arasındaki ilişki de üzerinde en fazla çalışılan konulardan biri olmuştur. Menopozal durum, tümörün karakteristiği ve optimal D vitamini alımı ve kandaki düzeyi de üzerinde durulan diğer konular arasındadır. Bu derleme yazıda D vitamini alımının ve kandaki düzeyinin meme kanseri insidansı ve mortalitesi üzerine etkileri tartışılmıştır.

Vitamin D and Breast Cancer

Recent studies show that, the hormone-like effect of vitamin D plays an important role not only in bone metabolism but also in other organ functions and focus on the association of vitamin D levels and disease development. The relationship between vitamin D and certain diseases such as cancer, autoimmune diseases, cardiovascular diseases has been one of the most extensively researched topics. Other issues which also discussed are menopausal status, tumor characteristics, optimal amount of vitamin D intake and serum levels. In our review, main debate is about the effect of intake and serum levels of vitamin D on breast cancer incidence and mortality.

PDF

___

1.Mataress L, Gottschlich M. Nutrition Support Practice: A Clinical Guide. USA, Elsevier Science; 2003.
2.Deeb KK, Trump DL, Johnson CS. Vitamin D signalling pathways in cancer: Potential for anticancer therapeutics. Nat Rev Cancer 2007;7:684-700.
3.Shao T, Klein P, Grossbard ML. Vitamin D and breast cancer. The Oncologist 2012;17: 36-45.
4.Tellioğlu A, Başaran S. Güncel Bilgiler Işığında Vitamin D. Archives Medical Review Journal 2013;22(2):259- 271.
5.Garland FC, Garland CF, Gorham ED, Young JF. Geographic variation in breast cancer mortality in the United States: A hypothesis involving exposure to solar radiation. Prevent Med 1990;19:614-622.
6. McCullough ML, Rodriguez C, Diver WR, Feigelson HS, Stevens VL, Thun MJ, et al. Dairy, calcium, vitamin D intake and postmenopausal breast cancer risk in the Cancer Prevention Study II Nutrition Cohort. Cancer Epidemiol Biomarkers Prev 2005;14:2898-2904.
7. John EM, Schwartz GG, Dreon DM, Koo J. Vitamin D and breast cancer risk: The NHANES I Epidemiologic Follow-Up Study, 19711975 to 1992. Cancer Epidemiol Biomarkers Prev 1999;8:399406.
8. Zeeb H, Greinert R. The role of vitamin D in cancer prevention. Dtsch Arztebl Int 2010;107(37):638-643.
9. Holick MF. Vitamin D: A millennium perspective. J Cell Biochem 2003;88:296-307.
10. Baysal A. Beslenme. 14. baskı (Ed:Baysal A, Aksoy M, Besler T, Bozkurt N, Keçecioğlu S, Kutluay MT ve arkadaşları). Hatipoğlu Basın ve Yayım San. Tic. Şti, Ankara, 2012.
11. Scarlett WL. Ultraviolet radiation: Sun exposure, tanning beds, and vitamin D levels. What you need to know and how to decrease the risk of skin cancer. JAOA 2003;103(8):371-375.
12. Robien K, Cutler GJ, Lanzovich D. Vitamin D intake and breast cancer risk in postmenopausal women: The Iowa Womens Health Study. Cancer Causes Control 2007;18:775-782.
13. Shin MH, Holmes MD, Hankinson SE, Kana Wu, Colditz GA, Willett WC. Intake of dairy products, calcium, and vitamin D and risk of breast cancer. J Natl Cancer Inst 2002;94:1717-1723.
14. Lin J, Manson JE, Lee IM, Cook NR, Buring JE, Zhang SM. Intakes of calcium and vitamin D and breast cancer risk in women. Arch Intern Med 2007;167:1050-1059.
15. Bertone-Johnson ER. Prospective studies of dietary vitamin D and breast cancer: More questions raised than answered. Nutr Rev 2007;65(10):459-466.
16. Carey LA, Dees EC, Sawyer L, Gatti L, Moore DT, Collichio F, et al. The triple negative paradox: Primary tumor chemosensivity of breast cancer subtypes. Clin Cancer Res 2007;13:2329-2334.
17. Booth SL, Tucker KL, McKeown NM, Davidson KW, Dallal GE, Sadowski JA. Relationships between dietary intakes and fasting plasma concentrations of fat-soluble vitamins in humans. J Nutr 1997;127:587592.
18. Rossi M, McLaughlin JK, Lagiou P, Bosetti C, Talamini R, Lipworth L, et al. Vitamin D intake and breast cancer risk: A case-control study in Italy. Ann Oncol 2009;20:374-378.
19. Heaney RP, Davies KM, Chen TC, Holick MF, Barger- Lux MJ. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr 2003:77(1);204-210.
20. Bertone-Johnson ER, Chen WY, Holick MF, Hollis BW, Coldtz GA, Willett WC, et al. Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D and risk of breast cancer. Cancer Epidemiol Biomarkers Prev 2005;14:1991-1997.
21. Kennel KA, Drake MT, Hurney DL. Vitamin D deficiency in adults: When to test and how to treat. Mayo Clin Prac 2010;85(8):752-758.
22. Holick MF. Vitamin D deficiency. N Engl J Med 2007;357:266-281.
23. Peppone LJ, Huston AJ, Reid ME, Roiser RN, Zakharia Y, Trump DL, et al. The effect of various vitamin D supplementation regimens in breast cancer patients. Breast Cancer Res Trent 2011;127:171-177.
24. Neuhouser ML, Sorensen B, Hollis BW, Ambs A, Ulrich CM, McTiernan A, et al. Vitamin D insufficiency in a multiethnic cohort of breast cancer survivors. Am J Clin Nutr 2008:88;133-139.
25. Eliassen AH, Spiegelman D, Hollis BW, Horst RL, Willett WC, Hankinson SE. Plasma 25-hydroxyvitamin D and risk of breast cancer in the Nurses Health Study II. Breast Cancer Res 2011;13(3):R50.
26. Garland C, Gorham E, Mohr S, Grant W, Giovannucci E, Lipkin M, et al. Vitamin D and prevention of breast cancer: Pooled analysis. J Steroid Biochem Mol Biol 2007;103:708-711.
27. Yin L, Grandi N, Raum E, Haug U, Arndt V, Brenner H. Meta-analysis: Serum vitamin D and breast cancer risk. Eur J Cancer 2010;46:2196-2205.
28. Goodwin P, Ennis M, Pritchard K, Koo J, Hood N, Lunenfeld S, et al. Vitamin D deficiency is common at breast cancer diagnosis and is associated with a significantly higher risk of distant recurrence and death in a prospective cohort study of T1-3, N0-1, M0 BC. J Clin Oncol 2008;26(Suppl):Abstract 511.
29. Garland CF, Gorham ED, Mohr SB, Garland FC. Vitamin D for Cancer Prevention: Global Perspective. Ann Epidemiol 2009;19:468-483.
30. Porojnicu AC, Lagunova Z, Robsahm TE, Berg JP, Dahlback A, Moan J. Changes in risk of death from breast cancer with season and latitude: Sun exposure and breast cancer survival in Norway. Breast Cancer Res Treat 2007;102:323-328.
31. Lazzeroni M, Gandini S, Puntoni M, Bonanni B, Gennari A, DeCensi A. The science behind vitamins and natural compounds for breast cancer prevention. Getting the most prevention out of it. The Breast 2011;20(S3):36- 41.
32. Igraham BA, Bragdon B, Nohe A. Molecular basis of the potential of vitamin D to prevent cancer. Curr Med Res Opin 2008;24(1):139-149.
33. Crew KD, Shane E, Cremers S, McMahon DJ, Irani D, Hershman DL. High prevalence of vitamin D deficiency despite supplementation in premenopausal women with breast cancer undergoing adjuvan chemotherapy. J Clin Oncol 2009;27:2151-2156.
34. Khan QJ, Reddy PS, Kimler BF, Sharma P, Baxa SE, ODea AP, et al. Effect of vitamin D supplementation on serum 25-hydroxy vitamin D levels, joint pain, and fatigue in women starding adjuvan letrozole treatment for breast cancer. Breast Cancer Res Treat 2010;119:111-118.
35. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from Institute of Medicine: What clinicians need to know. J Clin Endocrinol Metab 2011;96:53-58.
36. Hines SL, Jorn HKS, Thompson KM, Larson JM. Breast cancer survivors and vitamin D: A review. Nutrition 2010;26:255-262.