K vitamininin Kardiyovasküler Sağlık Üzerine Etkisi: Güncel Yaklaşımlar

K vitamini doğada filokinon ve menakinon olmak üzere iki şekilde bulunmaktadır. K vitamininin en bilinen biyokimyasal rolü gama (?-) glutamil karboksilaz enzimi için koenzim görevidir. En bilinen işlevi ise hepatik kan kaogülasyon faktörleri sentezi üzerinde gösterdiği etkidir. Son yıllarda K vitamininin kan koagülasyonu dışında vasküler hastalıkların önlenmesinde ve tedavisinde de etkili olduğu bildirilmektedir. Yapılan çalışmalarda K vitamini varfarin benzeri oral antikoagülan kullanımının koagülasyon faktörlerinin sentezini azaltarak, arteriyal tromboz riskini düşürdüğü bilinmektedir. Yeni yapılan çalışmalarda ise antikoagülan kullanımının K vitamini ile ilişkili olarak arteriyal kalsifikasyonlara neden olabileceği belirtilmektedir. Bu derleme yazıda K vitamininin kardiyovasküler hastalıklar, arter kalsifikasyonu ve ilaç etkileşimleri ile ilişkisi ele alınmıştır

The Effect of Vitamin K on Cardiovascular Health: Recent Current Approaches

Vitamin K is found in two forms in nature, phylliquinone and menaquinone. The most known biochemical role of vitamin K is the coenzym for gamma (γ-) glutamyl carboxylase enzyme. The most known function of vitamin K is the effect on hepatic blood coagulation factors synthesis. In recent years it has been reported that vitamin K is also effective in the prevention and treatment of vascular diseases besides blood coagulation. Studies have indicated that insufficient or low intake of vitamin K may be associated with arterial calcification. It is known that the use of warfarin-like oral anticoagulants reduces the risk of arterial thrombosis by reducing the synthesis of coagulation factors. In recent studies, it is stated that the use of anticoagulant may cause arterial calcifications in association with vitamin K. In this review article, vitamin K is discussed in relation to cardiovascular diseases, arterial calcification and drug interactions

Kaynakça

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