Erkek İnfertilitesinde Antioksidanların Rolü

İnfertilite dünya çapında global bir sorun olmakla birlikte erkek infertilitesinin dünyadaki infertilite vakalarının yarısına yakınını oluşturduğu belirtilmektedir. İdiyopatik oligospermi (düşük sperm sayısı, spesifik tedavisi hala bilinmeyen), tam astenozoospermi (sperm motilitesinin olmaması) ve izole astenozoospermi (varikosel, enfeksiyon ya da genetik etmenler nedeniyle, düşük sperm motilitesi) gibi birçok hastalık erkek infertilitesine neden olabilir. Erkek infertilitesinde diyetle alınan besin ögelerinin ve desteklerin koruyucu etkisinin olabileceğini ve infertiliteye engel olabileceğini gösteren çalışmalar bulunmaktadır. Özellikle diyetle alınan antioksidan ögelerin ve antioksidan desteklerinin sperm kalitesi, morfolojisi, motilitesi ve sayısı üzerine olumlu etkilerinin gösterildiği çalışmalar bulunmaktadır. Ancak besin desteklerinin hangi dozda ve ne kadar süreyle kullanıldığında olumlu etki gösterdiğine dair bir rehber bulunmamaktadır. Bu derleme yazıda, erkek infertilitesinde diyetle ve besin desteğiyle antioksidan alımının etkisi incelenmiştir.

The Role of Antioxidants in Male Infertility

Infertility is a global medical concern worldwide, and studies report that male factor infertility contributes to almost half of infertility cases globally. Several different disorders can cause male infertility, including idiopathic oligospermia (low sperm counts, for which a specific treatment remains unknown), complete asthenozoospermia (absence of sperm motility), and isolated asthenozoospermia (low sperm motility, caused by sperm dysfunction, varicocele, infection, or genetic factors). There are studies showing that in male infertility there may be protective effects of dietary sources and supplements and that even it may reverse infertility. Studies show that especially vitamin and antioxidant supplements have positive effects on sperm quality, morphology, motility and count. However, there is no guideline on the useful effect of these supplements. In this review article, the effect of dietary intake of antioxidants and antioxidant supplementation on male infertility was examined.

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