Çörek Otunun Lipit Profili ve Glikoz Regülasyonu Üzerine Etkisi

Çörek otu binlerce yıldır pek çok hastalığın tedavisinde kullanılmakta olan bir bitkidir. Bu derlemede çörek otunun lipit profili ve glikoz regülasyonu ile ilişkisini bilimsel literatür verileri doğrultusunda incelenmesi amaçlanmıştır. Literatürde çörek otunun kan lipit düzeyleri üzerine etkinliğini değerlendiren çok sayıda çalışma mevcut olup bunların hemen hepsinde çörek otunun hipolipidemik etkisi göze çarpmaktadır. Özellikle çörek otunun trigliserit, LDL-kolesterol ve total kolesterol düzeyleri üzerine olumlu etkileri saptanırken HDL-kolesterol düzeyini genel olarak etkilemediği belirlenmiştir. Pek çok çalışmada çörek otunun, hipolipidemik etkisi gibi, hipoglisemik etkilerinin de mevcut olduğu görülmüştür. Yapılan toksisite çalışmalarında çörek otu kullanımı için geniş bir güvenlik sınırı vurgulanmakla birlikte, literatürde akut böbrek yetmezliği ve alerjik reaksiyonlara yol açabildiğini gösteren olgu sunumları da bulunmaktadır. Ayrıca çörek otunun gösterdiği olumlu etkileri hangi sistemler üzerinden gerçekleştirdiği kesinleşmemiş olup uluslararası geçerliliği olan kılavuzlarda çörek otu tedavisine yer verilmemiş olması nedeniyle özellikle çörek otu tozu, yağı ve çeşitli ekstraktlarının tedavi amaçlı kullanımının hastalara önerilmemesi gerekmektedir

Effect of Nigella Sativa on Lipid Profile and Glucose Regulation

Nigella sativa is a plant which has been used for treatment of many diseases. In this compilation, we aimed to investigate the relation of the Nigella sativa with lipid profile and glucose regulation in light of scientific literature data. In the literature, there are various studies that evaluate effectiveness of Nigella sativa on blood lipid levels, and in almost all of these, hypolipidemic effect of Nigella sativa attracts the attention. While positive effects of Nigella sativa especially on triglyceride, LDL-cholesterol and total cholesterol levels have been determined, it has been suggested that generally it does not influence the HDL-cholesterol levels. In many studies, it has been observed that Nigella sativa has not only hypolipidemic, but also hypoglycemic effects. In toxicity studies, along with that safety margin for Nigella sativa use has been emphasized, there are some case reports in the literature demonstrating that it can lead to acute renal failure and allergic reactions. In addition to this, although on which systems Nigella sativa has positive effects have been uncertain, we are in thought of that powder, oil and various extracts of Nigella sativa should not be recommended to patients for therapeutic purpose due to that treatment with Nigella sativa has not been included in international guidelines

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