Kürşad BİRDANE, İbrahim KELEŞ, Fatih AVDATEK, Mustafa GÜNDOĞAN, Deniz YENİ, Mehmet Fatih BOZKURT

Yetişkin Wistar Erkek Ratlarda Amlodipinin Spermatolojik Parametreler ve Genital Organ Ağırlıkları Üzerine Etkileri

Kalsiyum iyonları, spermatozoon motilitesi, akrozom reaksiyonu ve hiperaktivasyon gibi pekçok spermatozoon fonksiyonu için çok önemlidir. Bu çalışmanın amacı kalsiyum kanal blokörü olan Amlodipinin yetişkin Wistar erkek ratlarda spermatolojik özellikler ve genital organ ağırlıkları ve spermatogenik hücre yoğunluğu üzerine etkilerini araştırmaktır.Yetişkin 12 erkek rat (12 haftalık yaşta, 290-350 gr ağırlıkta) her grupta 6 rat olacak şekilde iki çalışma grubuna ayrıldı. Grup I'de bulunan ratlar AML bulunmayan normal diyetle beslenip kontrol grubunu oluştururken Grup II'ye oral gavaj yolu ile 30 gün süreli 0.04 mg/gün dozunda AML verildi. Kontrol grubuna göre AML grubunda motilite, sol testis, sağ epididimis, prostat ağırlıklarında azalma, anormal spermatozoon oranında ise artış istatistiki açıdan (P

Effects of Amlodipine on Spermatological Parameters and Genital Tract Weight in Adult Wistar Male Rats

Calcium ions are very important for many sperm functions involving sperm motility, reaction, and hyperactivation. The purpose of this study was to examine the effect of calcium channel blocker (CCB), Amlodipine (AML), on spermatological features, genital tract weight and spermatogenic cell density in adult male Wistar rats. Twelve rats (age, 12 weeks; weight, 290-350 g) were divided into two groups, six rats per each. Group I rats were fed normal diet without AML served as the control, Group II received 0.04 mg/daily AML for 30 days by oral gavage. Motility, left testis, right epididymis, prostate weight were decreased, and abnormal sperm rate was significantly (P

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