Platelet kaynaklı büyüme faktörünün yapısı, fonksiyonları ve gelişim üzerine etkileri

Memelilerde kan pulcukları (platelet) ve kanatlılarda trombositler pıhtı oluşumunda görev alan kan hücreleridir. İlk olarak plateletlerden eksprese edildiği için platelet kaynaklı büyüme faktörü olarak adlandırılan PDGF, büyüme faktörleri ailesinin bir üyesidir. PDGF, prenatal ve postnatal dönemde; hücresel proliferasyon, kemotaksis, dokuların şekillenmesi ve yara iyileşmesi gibi birçok görev üstlenmektedir. Dolayısıyla, bu derlemenin amacı, PDGF’nin yapısal özellikleri, fonksiyonları ve gelişim üzerine etkilerinin değerlendirilmesidir.

The effects of platelet derived growth factor upon the structure, functions and growth

Platelets in mammals and trombocytes in avian are the blood cells, as both playing roles in the coagulation. Platelet derived growth factor, PDGF, as firstly expressed in the platelets, is a member of the family of growth factors. It has many functions such as cell proliferation, chemotaxis, tissue formation and wound healing in prenatal and postnatal periods. Therefore, the aim of this review was to evaluate the effects of PDGF upon the structural proporties, functions and growth.

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