Maternal tolerans

Gebelik, babaya ait antijenler taşıyan embriyonik hücrelere karşı annenin bağışıklık sisteminin bölgesel toleransı ile karakterize fizyolojik bir durumdur. Genetik materyalinin yarısı babadan gelmesine karşın, memeliler embriyolarını uterus içerisinde taşırlar. Embriyonun uterusta yaşaması ve gelişimini sürdürebilmesi için belli bazı immunolojik mekanizmalar söz konudur. Sunulan derlemede, maternal tolerans olarak ta bilinen annenin bağışıklık sisteminin yarı yarıya kendinden olan embriyoya nasıl ''tahammül'' ettiği kısaca tartışılmıştır.

Maternal tolerance

Pregnancy is a physiologic condition characterized by a local tolerance of the maternal immune system to the paternal antigens expressed by the embryonic cells. Mammals carry their embryos within their uterus although half of their genetic material comes from the father. There are some certain immunologic mechanisms to allowing the survival and growth of the embryo in the uterus. In this review, how the maternal immune system can tolerate the semi-allogenic embryo, known as maternal tolerance, is discussed briefly.

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