Kaveh AZIMZADEH, Mortaza MAHAN, Negar Zamani HERGALANI, Tohid ZAHED

Koyun Babeziozisinde Plazma Arginaz, Gelsolin ve Sistatin C Arasında Olası Potansiyel Biyobelirteç Tayini: Parazitemi Oranına Göre

Bu çalışmanın amacı, koyun babeziosisinde arginaz aktivitesi, gelsolin (GLS) ve sistatin c (Cys c) seviyelerini ve potansiyel biyobelirteç tespitini incelemektir. Patojen kan parazitleri olan Babesia türleri, hayvancılık yönetiminde ekonomik sorunlara neden olur. Yayımlanan birçok çalışmada babeziosis kaynaklı biyokimyasal parametreler önerilmiş, ancak hiç kimse bu parametrelerdeki duyarlılık ve özgüllüğü ve değişiklikleri açıklığa kavuşturmamıştır. Akut babeziosisli koyunlar, kırmızı kan hücrelerinde Piroplazma formlarının görülmesi ve klinik bulgulara göre belirlendi. Yirmibeş adet enfekte ve aynı sayıda sağlıklı koyunlardan alınan kan örneklemesinden sonra, yukardaki parametreler plazmada ölçüldü. Sonuçlar, arginaz ve Cys c'de anlamlı bir artış (P

Determination of Possible Potential Biomarker Between Plasma Arginase, Gelsolin and Cystatin C in Sheep Babesiosis: Based on Parasitemia Rate

The aim of this study was to assay arginase activity, gelsolin (GLS) and cystatin c (Cys c) levels and determination ofpotential biomarker in sheep babesiosis. The Babesia genus as pathogen blood parasites causes economic problems inlivestock management. Many published studies have suggested babesiosis-induced biochemical parameters, but no one havedetermined those parameters alterations and clarification of sensitivity and specificity. Sheep with acute babesiosis wereidentified based on clinical signs and the observation of Piroplasm forms in red blood cells. After blood sampling from 25infected and same number healthy sheep, above parameters measured in plasma. The results indicated significant increase(P

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