Ayşe KANICI, Ishrage G. IBRAHIM, Nurgül ATMACA, Ender YARSAN

Evaluation of effects of enrofloxacin on some haematological parameters in broilers

Bu çalışmada, enrofloksasinin yüksek dozlarının broyler piliçlerde bazı kan parametreleri üzerine etkileri araştırıldı. Toplam 50 adet, Ross-308, 1 günlük erkek broyler kullanıldı. Broylerler (10 günlük) dört gruba ayrıldı: Grup 1 (kontrol) ve Grup 2, 3 ve 4’e sırasıyla 10, 100 ve 200 mg/kg vücut ağırlığı olacak şekilde 30 gün boyunca enrofloksasin uygulaması yapıldı. Tedavi süresi sonunda kan değerlerini belirlemek amacıyla kan örnekleri toplandı. Kan parametreleri manuel metotla tespit edildi. RBC Grup 3 ve 4’te düşük; Hb, Grup 2’de yüksek, Grup 3 ve 4’te düşük; MCV düzeyleri Grup 3 ve 4’te yüksek; MCH, Grup 2, 3’te yüksek, Grup 4’te düşük; MCHC, Grup 3 ve 4’te düşük bulundu. WBC değerinde Grup 3 ve 4’te azalma vardı. Bu çalışmada, enrofloksasinin önerilen 10 mg/kg dozunun yaklaşık 10 ve 20 katının 30 gün boyunca ağız yoluyla uygulanmasının, broylerlerde bazı hematolojik değerleri değiştirdiği sonucuna varıldı. Bununla birlikte, broylerlerde anemi ve lökopeni şekillendiği belirlendi.

Broylerlerde enrofloksasinin bazı kan değerleri üzerine etkilerinin değerlendirilmesi

In the present study, effects of enrofloxacin overdose on some haematological parameters of broiler chickens were investigated. A total of 50, Ross-308 one-day-old male broiler chickens were used. Broilers (10 days old) were divided into four groups: Animals in Group 1 (kept as control) and Group 2, 3 and 4 were administered 10, 100 and 200mg/kg body weight enrofloxacin for 30 consecutive days, respectively. Samples of blood were then collected to determine the haemato-logical values. Haematological parameters were determined manually. Results revealed that the RBC decreased in Group 3 and 4; the Hb increased in Group 2 and decreased in Group 3 and 4; the MCV levels were higher in Group 3 and 4; the MCH increased in Group 2, 3 and decreased in Group 4; the MCHC decreased in Group 3 and 4. There were declines in the WBC in Group 3 and 4. The results suggest that the oral administration of enrofloxacin at approximately 10- and 20-fold of the proposed dosage of 10 mg /kg for up to 30 days altered some haematological parameters in broiler chickens. Additionally, it was shown that the resultant anaemia and leucopoenia occurred in broilers.

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