Bazı Viral Enfeksiyonlarda Melatoninin Etkileri

Melatonin,pinealbezdensalınanvesentezlenmesiiçinprimerolarakkaranlığabağımlıolanönemlibirhormondur. Melatoninin kardiyak ritmin düzenlenmesi, immunregülasyon mekanizmaları, serbest radikal süpürücülüğü, antioksidan fonksiyonlar, onkostatik olaylar, reprodüktif fonksiyonların kontrolü, duyguların düzenlenmesi ve uyku gibi organizmanınbirçokfonksiyonundaroloynadığıdayapılançalışmalarlabirçokkezortayakonmuştur. Melatonininorganizmadakiönemlietkilerinden birisi de immun sistem üzerine olan etkisidir. Melatonin, immun sistem hücrelerini doğrudan ya da dolaylıyollarlaaktiveeder,apoptozisidüzenlervegüçlübirantioksidandır. Buçalışmadamelatonininimmunsistemfonksiyonlarıüzerindekietkileriyanı sıra,VenezuelanEquineEnsefalitis,BatıNilVirusu,SemlikiForestViru s,Retroviruslar,RespiratuarSinsityal Virus ve VizonlarınAleutianHastalığıgibi bazı viralenfeksiyonların tedavisinde ya tek başına yada diğerilaçlarlabirlikte kombine edilerek kullanıldığı çalışmalar ile ilgili veriler derlenmiştir. Bu çalışmalarda melatoninin vücuttaki virusmiktarınıazalttığı, ölüm oranını düşürdüğü,viralenfeksiyonlar sırasında oluşan oksidatif streskaynaklı hasarlarıazaltaraksemptomları hafiflettiği bildirilmiştir. Sonuç olarak, viral enfeksiyonların tedavileri sırasındayaşanan çaresizlikler dikkatealındığında, elde edilen bu verilere de dayanılarak melatoninin birçok viralenfeksiyonun tedavisinde destekleyici tedaviseçeneği olabileceğiakıldabulundurulmalıdır.

The Efficacy of Melatonin in Some Viral Infections

Melatonin is an important hormone released by pineal gland that its synthesis is primarily dependent on thedarkness. Melatonin has many functions in the organism, such as the regulation of cardiac rhythm, immunoregulatorymechanisms, free- radical scavenger, antioxidant functions, oncostatic actions, control of reproductive functions, regulationof emotions, and sleep. Also, one of the major effects of melatonin identified is the activation of immune system cells eitherdirectly or indirectly, along with being a modulator of apoptosis and a potent antioxidant. In this study, data collected onthe effects of melatonin upon the immune system functions as well as the studies regarding the treatment options when itis combined with other drugs to combat with some viral infections like Venezuelan Equine Encephalitis, West Nile V irus,Selmiki Forest V irus, Retrovirus, Respiratory Syncytial Virus and Mink Aleutian V irus were reviewed. In these studies, it hasbeen reported that melatonin was lowered the amount of the virus, reduced the infection mortality rate and alleviate thesymptoms of the viral infections due to the effects of oxidative stress. As a result, one should keep in mind that melatonincould be a supportive therapy option during the treatment of viral infections.

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