Sezaryen Skar Yeri Ektopik Gebeliği

Çalışmamızın amacı sezaryen skar ektopik gebeliğinin ilk olgu sunumu olarak yayınlandığı 1978 ile Mart 2017 tarihleriarasında literatürde yer almış çalışmaları gözden geçirmek ve, sezaryen skar ektopik gebeliğinin yönetiminde kullanılangüncel tanı ve tedavi yöntemlerini karşılaştırmaktır. Sezaryen skar ektopik gebeliğinin ayırıcı tanısında serum humanchorionic gonadotropin düzeyi saptanması, ultrasonografi, doppler ultrasonografi ve bazı durumlarda da manyetikrezonans görüntüleme kullanılmaktadır. Standart bir tedavi yöntemi tanımlanmamakla birlikte en sık olarak dilatasyonve küretaj, lokal veya sistemik metotreksat uygulanması, selektif uterin arter embolizasyonu ve histerotomiuygulanmaktadır.

Ectopic Pregnancy Located at the Cesarean Scar

The aim of our study is to review previous studies in literature on caesarean scar ectopic pregnancy between 1978; the year the first case was reported and March 2017, and to compare the current diagnostic and treatment methods used in management of caesarean scar ectopic pregnancy. Measurement of serum human chorionic gonadotropin levels, ultrasonography, doppler ultrasonography and sometimes magnetic resonance imaging are used for differential diagnosis of caesarean scar ectopic pregnancy. The most common treatment methods are; dilatation and curettage, local or systemic methotrexate application, selective uterine artery embolization and hysterotomy.

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  • 1. NICE guidelines [CG154]. Ectopic pregnancy and miskarriage: diagnosis and initial management in early pregnancy of ectopic pregnancy and miscarriage. 2012, https://www. ncbi.nlm.nih.gov/ pubmed/23638497.
  • 2. Clark EAS, Silver RM. Long-term maternal morbidity associated with repeat cesarean delivery. AJOG 2011;205(6 Suppl.):S2e10).
  • 3. Larsen JV, Solomon MH. Pregnancy in a uterine scar sacculus an unusual cause of postabortal haemorrhage. A case report. S Afr Med J. 1978 28;53:142-3.
  • 4. Richardson A, Gallos I, Dobson S, Campbell BK, Coomarasamy A, Raine-Fenning N. Accuracy of first-trimester ultrasound in diagnosis of tubal ectopic pregnancy in the absence of an obvious extrauterine embryo: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2016;47:28–37
  • 5. Timor-Tritsch IE, Monteagudo A, Santos R, Tsymbal T, Pineda G, Arslan AA. The diagnosis, treatment, and follow-up of cesarean scar pregnancy. AJOG. 2012; 207:44.e1e44.e13.
  • 6. Litwicka K, Greco E. Caesarean scar pregnancy: a review of management options. Curr Opin Obstet Gynecol. 2013;25:456e61.
  • 7. Fylstra DL. Ectopic pregnancy within a cesarean scar: a review. Obstet Gynecol Surv. 2002;57:537–43.
  • 8. Godin P-A, Bassil S, Donnez J. An ectopic pregnancy developing in a previous caesarean section scar. Fertil Steril. 1997;67:398–400
  • 9. Maymon R, Halperin R, Mendlovic S, Schneider D, Herman A. Ectopic pregnancies in a caesarean scar: review of the medical approach to an iatrogenic complication. Hum Reprod Update. 2004;10:515–23
  • 10. Zhang Y, Gu Y, Wang JM, Li Y. Analysis of cases with cesarean scar pregnancy. J Obstet Gynaecol Res. 2013;39:195–202.
  • 11. Rotas MA, Haberman S, Levgur M. Cesarean scar ectopic pregnancies: etiology, diagnosis, and management. Obstet Gynecol. 2006;107:1373–81.
  • 12. Kung FT, Huang TL, Chen CW, Cheng YF. Image in reproductive medicine. Cesarean scar ectopic pregnancy. Fertil Steril. 2006;85:1508–1509.
  • 13. Shih JC. Cesarean scar pregnancy: diagnosis with three-dimensional (3D) ultrasound and 3D power Doppler. Ultrasound Obstet Gynecol. 2004;23:306–7.
  • 14. Roberts H, Kohlenber C, Lanzarone V, Murray H. Ectopic pregnancy in lower segment uterine scar. Aust N Z J Obstet Gynaecol. 1998;38:114–16.
  • 15. Maymon R, Halperin R, Mendlovic S, Schneider D, Vaknin Z, Herman A, et al. Ectopic pregnancies in Caesarean scars: the 8 year experience of one medical centre. Hum Reprod. 2004;19:278–84.
  • 16. Caserta NMG, Bacha AM, Grassiotto OR. Cesarean scar ectopic pregnancy: invasion of the bladder wall detected by magnetic resonance imaging. Radiol Bras. 2017;50:197-8.
  • 17. Huang Q, Zhang M, Zhai RY. The use of contrast-enhanced magnetic resonance imaging to diagnose cesarean scar pregnancies. Int J Gynaecol Obstet. 2014;127:144–6.
  • 18. Caserta NMG, Bacha AM, Grassiotto OR. Cesarean scar ectopic pregnancy: invasion of the bladder wall detected by magnetic resonance imaging. Radiol Bras. 2017;50:197–8.
  • 19. Jiang S, Sheng X, Li Q. Endoscopy Surgery for Ectopic Pregnancy Within Cesarean Scar. J Minim Invasive Gynecol. 2015;22:80-1.
  • 20. Michaels AY, Washburn EE, Pocius KD, Benson CB, Doubilet PM, Carusi DA. Outcome of cesarean scar pregnancies diagnosed sonographically in the first trimester. J Ultrasound Med. 2015;34:595–9.
  • 21. Pavlova E, Gunev D, Diavolov V, Slavchev B. Cesarean scar ectopic pregnancy: diagnosis with 2D, three-dimensional (3D) ultrasound and 3D power doppler of a case and review of the literatüre. Akush Ginekol (Sofia). 2013;52:43-52.
  • 22. Yang Q, Piao S, Wang G, Wang Y, Liu C. Hysteroscopic surgery of ectopic pregnancy in the cesarean section scar. J Minim Invasive Gynecol. 2009;16:432–6.
  • 23. Wang CJ, Yuen LT, Chao AS, Lee CL, Yen CF, Soong YK. Caesarean scar pregnancy successfully treated by operative hysteroscopy and suction curettage. BJOG. 2005;112:839e40.
  • 24. Wang CJ, Chao AS, Yuen LT, Wang CW, Soong YK, Lee CL. Endoscopic management of cesarean scar pregnancy. Fertil Steril. 2006;85:494–7.
  • 25. Wang YL, Su TH, Chen HS. Laparoscopic management of an ectopic pregnancy in a lower segment cesarean section scar: a review and case report. J Minim Inv Gynecol. 2005;12:73–9.
  • 26. Wang YL, Su TH, Chen HS. Operative laparoscopy for unruptured ectopic pregnancy in a caesarean scar. BJOG. 2006;113:1035–8.
  • 27. Wang JH, Xu KH, Lin J, Xu JY, Wu RJ. Methotrexate therapy for cesarean section scar pregnancy with and without suction curettage. Fertil Steril. 2009;92:1208–13.
  • 28. Cok T, Kalayci H, Ozdemir H, Haydardedeoglu B, Parlakgumus AH, Tarim E. Transvaginal ultrasound-guided local methotrexate administration as the first-line treatment for cesarean scar pregnancy: follow-up of 18 cases. J Obstet Gynaecol Res. 2015;41:803–8.
  • 29. Seow KM1, Wang PH, Huang LW, Hwang JL. Transvaginal sono-guided aspiration of gestational sac concurrent with a local methotrexate injection for the treatment of unruptured cesarean scar pregnancy. Arch Gynecol Obstet. 2013;288:361-6.
  • 30. Li N, Zhu F, Fu S, Shi X. Transvaginal ultrasound-guided embryo aspiration plus local administration of low-dose methotrexate for caesarean scar pregnancy. Ultrasound Med Biol. 2012;38:209–13.
  • 31. Wang JH, Xu KH, Lin J, Xu JY, Wu RJ. Methotrexate therapy for cesarean section scar pregnancy with and without suction curettage. Fertil Steril. 2009;92:1208–13.
  • 32. The Practice Committee of the American Society for Reproductive Medicine. Medical treatment of ectopic pregnancy: a committee opinion. Fertil Steril. 2013;100:638e44.
  • 33. Sevket O, Keskin S, Ates S, Molla T, Dansuk R, Yazicioglu HF et al. Is methotrexate administration needed for the treatment of caesarean section scar pregnancy in addition to suction curettage? Eur J Contracept Reprod Health Care. 2014;19:128–33.
  • 34. Kutuk MS, Uysal G, Dolanbay M, Ozgun MT. Successful medical treatment of cesarean scar ectopic pregnancies with systemic multidose methotrexate: single-center experience. J Obstet Gynaecol Res. 2014;40:1700–6.
  • 35. Yang MJ, Jeng MH. Combination of transarterial embolization of uterine arteries and conservative surgical treatment for pregnancy in a caesarean section scar: a report of 3 cases. J Reprod Med. 2003;48:213e6.
  • 36. Fahg A, Chen Q, Qian Z, Meng Y. Correlation questions clinical discussion of uterine artery embolization in induced abortion patients with management of cesarean scar pregnancy. J Reprod Contraception. 2009;20:153–60.
  • 37. Shen L, Tan A, Zhu H, Guo C, Liu D, Huang W. Bilateral uterine artery chemoembolization with methotrexate for cesarean scar pregnancy. Am J Obstet Gynecol. 2012; 207:386.e1–6.
  • 38. Lian F, Wang Y, Chen W, Li J, Zhan Z, Ye Y, et al. Uterine artery embolization combined with local methotrexate and systemic methotrexate for treatment of cesarean scar pregnancy with different ultrasonographic pattern. Cardiovasc Intervent Radiol. 2012;35:286–91.
  • 39. Yang XY, Yu H, Li KM, Chu YX, Zheng A. Uterine artery embolization combined with local methotrexate for treatment of caesarean scar pregnancy. BJOGl. 2010; 117:990e6.
  • 40. Zhuang Y, Huang L. Uterine artery embolization compared with methotrexate for the management of pregnancy implanted within a cesarean scar. Am J Obstet Gynecol. 2009; 201:152.e1–3.
  • 41. Yin X, Su S, Dong B, Ban Y, Li C, Sun B. Angiographic uterine artery chemoembolization followed by vacuum aspiration: an efficient and safe treatment for managing complicated cesarean scar pregnancy. Arch Gynecol Obstet. 2012; 285:1313–8.
  • 42. Wang JH, Xu KH, Lin J, Xu JY, Wu RJ. Methotrexate therapy for cesarean section scar pregnancy with and without suction curettage. Fertil Steril. 2009; 92:1208–13.
  • 43. Uludag SZ, Kutuk MS, Ak M, Ozgun MT, Dolanbay M, Aygen EM, et al. Comparison of systemic and local methotrexate treatments in cesarean scar pregnancies: time to change conventional treatment and follow-up protocols. Eu J of Obs & Gyn and Rep Bio. 2016;206:131–5.
  • 44. Jiang T, Liu G, Huang L, Ma H, Zhang S. Methotrexate therapy followed by suction curettage followed by Foley tamponade for caesarean scar pregnancy. Eur J Obstet Gynecol Reprod Biol. 2011;156:209–11.
  • 45. Wang G, Liu X, Bi F, Yin L, Sa R, Wang D, et al. Evaluation of the efficacy of laparoscopic resection for the management of exogenous cesarean scar pregnancy. Fertil Steril. 2014;101:1501–7.
  • 46. Wang YL, Weng SS, Huang WC, Su TH. Laparoscopic management of ectopic pregnancies in unusual locations. Taiwan J Obstet Gynecol. 2014; 53:466–70.
  • 47. Wang HY, Zhang J, Li YN, Wei W, Zhang DW, Lu YQ et al. Laparoscopic management or laparoscopy combined with transvaginal management of type II cesarean scar pregnancy. JSLS. 2013;17:263–72.
  • 48. Deans R, Abbot J. Hysteroscopic management of cesarean scar ectopic pregnancy. Fertil Steril. 2010;93:1735e40.
  • 49. Chao A, Wang TH, Wang CJ, Lee CL, Chao AS. Hysteroscopic management of caesarean scar pregnancy after unsuccessful methotrexate treatment. J Minim Invasive Gynecol. 2005;12:374e6.
  • 50. Chen H, Zhou J, Wang H, Tan W, Yao M, Wang X. The Treatment of Cesarean Scar Pregnancy with Uterine Artery Embolization and Curettage as Compared to Transvaginal Hysterotomy. Eur J Obstet Gynaecol Reprod Biol. 2017;214: 44– 9. 51. Timor-Tritsch IE, Monteagudo A, Bennett TA, Foley C, Ramos J, Kaelin Agten A. A new minimally invasive treatment for cesarean scar pregnancy and cervical pregnancy. Am J Obstet Gynecol. 2016; 215:351.e1-8.
  • 52. Huanxiao Z, Shuqin C, Hongye J, Hongzhe X, Gang N, Chengkang X et al. Transvaginal hysterotomy for cesarean scar pregnancy in 40 consecutive cases. Gynecol Surg. 2015;12:45–51.
  • 53. He M, Chen MH, Xie HZ, Yao SZ, Zhu B, Feng LP et al. Transvaginal removal of ectopic pregnancy tissue and repair of uterine defect for caesarean scar pregnancy. BJOG. 2011;118:1136–9.
  • 54. Kang SY, Park BJ, Kim YW, Ro DY. Surgical management of cesarean scar ectopic pregnancy: hysterotomy by transvaginal approach. Fertil Steril. 2011;96:e25–8.
  • 55. Le A, Shan L, Xiao T, Zhuo R, Xiong H, Wang Z. Transvaginal surgical treatment of cesarean scar ectopic pregnancy. Arch Gynecol Obstet. 2013;287:791–6.
  • 56. Li JB, Kong LZ, Fan L, Fu J, Chen SQ, Yao SZ. Transvaginal surgical management of cesarean scar pregnancy: analysis of 49 cases from one tertiary care center. Eur J Obstet Gynaecol Reprod Biol. 2014;182:102–6.
  • 57. Zhang H, Shi J, Yang Y, Liang Y, Gao X, Wang J et al. Transvaginal surgical management of cesarean scar pregnancy II (CSPII): an analysis of 25 cases. Med Sci Monit. 2015;21:3320–6.
  • 58. Goynumer G, Gokcen C, Senturk B, Turkgeldi E. Treatment of a viable caesarean scar pregnancy with transvaginal methotrexate and potassium chloride injection. Arch Gynecol Obstet. 2009;280:869–72.
  • 59. Zhu X, Deng X, Wan Y, Xiao S, Huang J, Zhang L et al. High-intensity focused ultrasound combined with suction curettage for the treatment of cesarean scar pregnancy. Medicine (Baltimore). 2015;94:e854.
  • 60. Hong Y, Guo Q, Pu Y, Lu D, Hu M. Outcome of high-intensity focused ultrasound and uterine artery embolization in the treatment and management of cesarean scar pregnancy. A retrospective study. Medicine (Baltimore). 2017;96:e7687.
  • 61. Xiao J, Zhang S, Wang F, Wang Y, Shi Z, Zhou X et al. Cesarean scar pregnancy: noninvasive and effective treatment with high-intensity focused ultrasound. Am J Obstet Gynecol. 2014; 211:356.e1–7.
  • 62. Timor-Tritsch IE, Khatib N, Monteagudo A, Ramos J, Berg R, Kovacs S. Cesarean scar pregnancies: experience of 60 cases. J Ultrasound Med. 2015;34: 601–10.
  • 63. Cheng LY, Wang CB, Chu LC, Tseng CW, Kung FT. Outcomes of primary surgical evacuation during the first trimester in different types of implantation in women with cesarean pregnancy. Fertil Steril. 2014;102:1085–90.e2.
  • 64. Cheng LY, Wang CB, Chu LC, Tseng CW, Kung FT. Outcomes of primary surgical evacuation during the first trimester in different types of implantation in women with cesarean scar pregnancy. Fertil Steril. 2014;102:1085–90.e2.
  • 65. Jurkovic D, Hillaby K, Woelfer B, Lawrence A, Salim R, Elson CJ. First trimester diagnosis and management of pregnancies implanted into the lower uterine segment Cesarean section scar. Ultrasound Obstet Gynecol. 2003 ;21:220e7.
  • 66. Zosmer N, Fuller J, Shaikh H, Johns J, Ross JA. Natural history of early firsttrimester pregnancies implanted in Cesarean scars. Ultrasound Obstet Gynecol. 2015;46:367–75.
  • 67. Marchiole P, Gorlero F, de Caro G, Podesta M, Valenzano M. Intramural pregnancy embedded in a previous cesarean section scar treated conservatively. Ultrasound Obstet Gynecol. 2004;23:307e9.
  • 68. Yamaguchi M, Honda R, Uchino K, Tashiro H, Ohba T, Katabuchi H. Transvaginal methotrexate injection for the treatment of cesarean scar pregnancy: efficacy and subsequent fecundity. J Minim Invasive Gynecol. 2014;21:877–83.
  • 69. Peng P, Gui T, Liu X, Chen W, Liu Z. Comparative efficacy and safety of local and systemic methotrexate injection in cesarean scar pregnancy. Ther Clin Risk Manag 2015;11:137–42.
  • 70. Jurkovic D, Ben-Nagi J, Ofilli-Yebovi D, Sawyer E, Helmy S, Yazbek J. Efficacy of Shirodkar cervical suture in securing hemostasis following surgical evacuation of Cesarean scar ectopic pregnancy. Ultrasound Obstet Gynecol.2007;30:95–100.
  • 71. Li C, Feng D, Jia C, Liu B, Zhan X. Transcatheter arterial chemoembolization versus systemic methotrexate for the management of cesarean scar pregnancy. Int J Gynecol Obstet. 2011;113:178–82.
  • 72. Gao L, Huang Z, Gao J, Mai H, Zhang Y, Wang X. Uterine artery embolization followed by dilation and curettage within 24 hours compared with systemic methotrexate for cesarean scar pregnancy. Int J Gynaecol Obstet. 2014;127:147–51.
  • 73. Zhang B, Jiang ZB, Huang MS, Guan SH, Zhu KS, Qian JS et al. Uterine artery embolization combined with methotrexate in the treatment of cesarean scar pregnancy: results of a case series and review of the literature. J Vasc Interv Radiol. 2012;23:1582–8.
  • 74. Zhang Y, Gu Y, Wang JM, Li Y. Analysis of cases with cesarean scar pregnancy. J Obstet Gynaecol Res. 2013;39:195–202.
  • 75. Arslan M, Pata O, Dilek TU, Aktas A, Aban M, Dilek S. Treatment of viable caesarean scar ectopic pregnancy with suction curettage. Int J Gynecol Obstet. 2005; 89:163e6.
  • 76. Sadeghi H, Rutherford T, Rackow B, Campbell KH, Duzyj CM, Guess MK et al. Cesarean scar ectopic pregnancy: case series and review of the literature. Am J Perinatol. 2010; 27:111e20.
  • 77. Wang C, Tseng C. Primary evacuation therapy for cesarean scar pregnancy: three new cases and review. Ultrasound Obstet Gynecol. 2006; 27:222e6.
  • 78. Weilin C, Li J. Successful treatment of endogenous cesarean scar pregnancies with transabdominal ultrasound-guided suction curettage alone. Eur J Obstet Gynecol Reprod Biol. 2014;183:20–2.
  • 79. Polat I, Ekiz A, Acar DK, Kaya B, Ozkose B, Ozdemir C et al. Suction curettage as first line treatment in cases with cesarean scar pregnancy: feasibility and effectiveness in early pregnancy. J Matern Fetal Neonatal Med. 2015:1–6.
  • 80. Wang CJ, Chao AS, Yuen LT, Wang CW, Soong YK, Lee CL. Endoscopic management of cesarean scar pregnancy. Fertil Steril. 2006;85:494.e1–4.
  • 81. Imbar T, Bloom A, Ushakov F, Yagel S. Uterine artery embolization to control haemorrhage after termination of pregnancy implanted in a caesarean delivery scar. J Ultrasound Med. 2003;22:1111e5.
  • 82. Le A, Shan L, Xiao T, Zhuo R, Xiong H, Wang Z. Transvaginal surgical treatment of cesarean scar ectopic pregnancy. Arch Gynecol Obstet. 2013;287: 791–6.
  • 83. Xiao J, Zhang S, Wang F, Wang Y, Shi Z, Zhou X et al. Cesarean scar pregnancy: noninvasive and effective treatment with high-intensity focused ultrasound. Am J Obstet Gynecol. 2014; 211:356.e1–7.
  • 84. Timor-Tritsch IE, Monteagudo A, Santos R, Tsymbal T, Pineda G, Arslan AA. The diagnosis, treatment, and follow-up of cesarean scar pregnancy. Am J Obstet Gynecol. 2012; 207:44.e1–13.
  • 85. Rotas MA, Haberman S, Levgur M. Cesarean scar ectopic pregnancies: etiology, diagnosis, and management. Obstet Gynecol. 2006;107:1373–81.
  • 86. Silver RM. Implications of the first cesarean: perinatal and future reproductive health and subsequent cesareans, placentation issues, uterine rupture risk, morbidity, and mortality. Semin Perinatol. 2012;36:315–23.
  • 87. Wang CN1, Chen CK, Wang HS, Chiueh HY, Soong YK. Successful management of heterotopic cesarean scar pregnancy combined with intrauterine pregnancy after in vitro fertilization-embryo transfer. Fertil Steril. 2007;88(3):706.e13-6. Epub 2007 Aug 6.
  • 88. Haiyan Yu, Hong Luo, Fumin Zhao, Xinghui Liu, and Xiaodong Wang. Successful selective reduction of a heterotopic cesarean scar pregnancy in the second trimester: a case report and review of the literatüre. BMC Pregnancy and Childbirth. 2016;16:380.
  • 89. Dor J, Seidman DS, Levran D, Ben-Rafael Z, Ben-Shlomo I, Mashiach S. The incidence of combined intrauterine and extrauterine pregnancy after in vitro fertilization and embryo transfer. Fertil Steril. 1991;55:833–4.
  • 90. Taşkin S, Taşkin EA, Ciftçi TT. Heterotopic cesarean scar pregnancy: how should it be managed? Obstet Gynecol Surv. 2009;64:690-5; quiz 697,
  • 91. Goldenberg JM, Bedaiwy MA. Transvaginal local injection of hyperosmolar glucose for the treatment of heterotopic pregnancy. Obstet Gynecol. 2006;107:509–10.
  • 92. O'Neill SM, Khashan AS, Kenny LC, Greene RA, Henriksen TB, Lutomski JE et al. Caesarean section and subsequent ectopic pregnancy: a systematic review and meta-analysis. BJOG. 2013;120:671–80.
  • 93. Ben Nagi J, Helmy S, Ofili-Yebovi D, Yazbek J, Sawyer E, Jurkovic D. Reproductive outcomes of women with a previous history of Caeseran scar ectopic pregnancies. Hum Reprod. 2007;22 2012.
  • 94. Ben Nagi J, Ofili-Yebovi D, Marsh M, Jurkovic D. First-trimester cesarean scar pregnancy evolving into placenta previa/accreta at term. J Ultrasound Med. 2005;24:1569e73.
  • 95. Timor-Tritsch IE, Monteagudo A. Unforeseen consequences of the increasing rate of cesarean deliveries: early placenta accreta and cesarean scar pregnancy. A review. Am J Obstet Gynecol. 2012;207:14–29.
  • 96. Sinha P, Mishra M. Caesarean scar pregnancy: a precursor of placenta percreta/ accreta. J Obstet Gynaecol. 2012;32:621–3.
  • 97. Chen MJ, Huang EC, HouMY. Abnormal placentation in caesarean scar ectopic pregnancy. BMJ Case Rep 2016. doi:10.1136/bcr-2016-217311.
  • 98. Timor-Tritsch IE, Monteagudo A. Unforeseen consequences of the increasing rate of cesarean deliveries: early placenta accreta and cesarean scar pregnancy. A review. Am J Obstet Gynecol. 2012; 207:14–29.
  • 99. Timor-Tritsch IE, Monteagudo A, Cali G, Vintzileos A, Viscarello R, Al-Khan A et al. Cesarean scar pregnancy is a precursor of morbidly adherent placenta. Ultrasound Obstet Gynecol. 2014; 44:246–53.
  • 100. Maheux-Lacroix S, Li F, Bojold E, Nesbit-Hawes E, Deans R, Abbot J. Cesarean Scar pregnancies: A Systemic Review of Treatment Options. J Minim Invasive Gynecol. 2017;24:915-25.