Ayşe DOĞAN, Kübra AKILLIOĞLU, Zehra Gül KOÇAKLI

Miyokardın Diyastolde Kalsiyum Homeostazı

Kardiyak miyositlerdeki uyarılma-kasılma ilişkisi hücre içi kalsiyum (Ca++) taşıma mekanizmaları tarafından düzenlenmektedir. Diyastol süreci, ventriküllerin kan ile yeterli dolumu için oldukça önemlidir. Kalbin kasılmasını takiben diyastol dönemi olan gevşeme safhasının gerçekleşebilmesi için intraselüler ortamdaki Ca++'un uzaklaştırılması gerekmektedir. Caolarak hücre membranı üzerindeki Na+-Ca++ değiştiricisi ve sarkoplazmik retikulum üzerindeki sarkoendoplazmik Ca++ ATPaz (SERCA 2a) mekanizmaları rol oynamaktadır. Bu derlemede, ventriküler gevşemenin, Cakonsantrasyonundaki değişikliklerin diyastolik fonksiyonu nasıl etkilediği hakkında bilgi verilmiştir

Calcium Homeostasis of the Myocardium at Diastole

Excitation-contraction relationship at cardiac myocyte is regulated by intracellular calcium transport mechanisms. The diastolic process is important for adequate blood filling into the ventricles. Following contraction of the heart, cytosolic Ca++ must be removed from intracellular milieu to relaxation phase of diastole period. Na+- Ca++ changer in sarkolemma and sarcoendoplasmic reticulum Ca ATPaz (SERCA 2a) mechanism in the sarcoplasmic reticulum basically are involved in Ca++ removing from cytosolic milieu. This article aims to review the control of ventricular relaxation by Ca++ homeostasis and changes of intracellular Ca++ concentration and their effects on diastolic function

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ISSN: 1300-3755
Yayın Aralığı: Yılda 4 Sayı
Başlangıç: 1992
Yayıncı: Çukurova Üniversitesi Tıp Fakültesi

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