Kawasaki Hastalığında Görülen Sıra Dışı Klinik Durumlar

Kawasaki hastalığı, gelişmiş ülkelerde edinsel kap hastalıklarının en sık sebebidir. Hastalık birçok klinik tablo ile ortaya çıkabilmekte olup hastalığa bağlı en önemli komplikasyon, koroner arter anevrizmasıdır. Ne kadar erken tanı konulursa ve tedaviye başlanırsa, bu komplikasyonun riski de o kadar azalır. Atipik Kawasaki hastalığı, klinik olarak hastalık kriterlerini karşılamayan ve normalde sık görülmeyen veya beklenmeyen organ ve sistem tutulumu olmasıyla karakterizedir. Hastaların yaklaşık % 7-10 kadarında atipik tutulum görülmektedir. Atipik hastalarda, tanının geç konulmasına bağlı koroner arter tutulumu daha sık görülür. Bu makalede, atipik Kawasaki hastalığına bağlı karşılaşılabilinen klinik durumlar, literatür bilgileri eşliğinde incelenmiştir.

Unusual Clinical Conditions in Kawasaki Disease

Kawasaki disease is the most frequent reason for acquired heart diseases in developed countries. The disease may develop with many clinical pictures and the most important disease-related complication is coronary arterial aneurysm. The sooner the diagnosis is made and treatment is initiated, the lower the risk for its complications to arise. Atypical Kawasaki disease is characterized by organ and system involvement, which do not clinically meet the disease criteria, are unexpected or not frequently seen under normal circumstances. Approximately 7-10% of the patients show atypical involvement. In atypical patients, coronary arterial involvement is more frequent as a result of late diagnosis. This article presents the clinical conditions that may be seen as a result of atypical Kawasaki disease in the light of literature data.

___

  • 1. Topçu S, Akgün Doğan Ö, Öz N, Tanır G. Kırk dokuz Kawasaki olgusunun değerlendirilmesi: Bir retrospektif Kohort çalışması. J Pediatr Inf. 2014;8:64-70.
  • 2. Baker AL, Lu M, Minich LL, Atz AM, Klein GL, Korsin R et al. Associated symptoms in the ten days before diagnosis of Kawasaki disease. J Pediatr. 2009;154:592-5.
  • 3. Moller JH, Hoffman IE. Pediatric Cardiovascular Medicine. Kato H, Suda K. Kawasaki Disease. Second Edition Wiley-Blackwell. 2012:919-37.
  • 4. Petrarca L, Nenna R, Versacci P, Frassanito A, Cangiano G, Nicolai A et al. Difficult diagnosis of atypical Kawasaki disease in an infant younger than six months: a case report. Ital J Pediatr. 2017;43:30-2.
  • 5. Tizard EJ. Complications of Kawasaki disease. Curr Paediatr 2005;15:62-8.
  • 6. Kayiran SM, Dindar A, Gurakan B. An evaluation of children with Kawasaki disease in Istanbul: a retrospective follow-up study.Clinics 2010;65:1261-5.
  • 7. Kocabaş A, Kardelen F, Aldemir-Kocabaş B, Akçurin G, Ertuğ H. Facial nerve palsy and Kawasaki disease. Indian J Pediatr. 2014;81:186-8.
  • 8. Arat C, Acar Y, Türkmenoğlu Y, Sayar T, Hamilçıkan SB, Sazak S, ve ark. Kawasaki hastalığı: 21 olgunun değerlendirilmesi. Cukurova Med J. 2016;41:97-104.
  • 9. Kontopoulou T, Kontopoulos DG, Vaidakis E, Mousoulis GP. Adult Kawasaki disease in a European patient: a case report and review of the literatüre. Journal of Medical Case Reports. 2015;75:1-7.
  • 10. Aldemir-Kocabaş B, Karbuz A, Karadeniz C, Çiftçi Ö, Özdemir H, Bolkent MG et al. Another face of Kawasaki disease. Turk J Pediatr. 2014;56:392-8.
  • 11. Binnetoglu A, Baglam T, Demir B, Kecelioglu Binnetoglu K, Sari M. Association Between Atypical/Incomplete Kawasaki Disease and Sensorineural Hearing Loss: A Case Report.Clin Pediatr (Phila) 2016;55(4):380-3.
  • 12. Singh S, Gupta D, Suri D, Kumar RM, Ahluwalia J, Das R et al. Thrombocytopenia as a presenting feature of Kawasaki disease: a case series from North India. Rheumatol Int. 2009;30:245-8.
  • 13. Yılmaz Çiftdoğan Y, Bayram SN, Bulut MO, Levent E, Özyürek R, Vardar F. Ender bulgularla başvuran iki inkomplet Kawasaki hastalığı. Çocuk Enf Derg. 2008;2:178-81.
  • 14. Shimakawa S, Yamada K, Hara K, Tanabe T, Tamai H. Seizure characteristics in Kawasaki disease.No To Hattatsu. 2008;40:289-94.
  • 15. Erdur CB, Katipoğlu N, Genel F, Özbek E, Özdemir R, Meşe T, ve ark. Akut gastroenterit ve intestinal ödem tablosu ile başvuran ve Kawasaki hastalığı tanısı alan bir infant: Olgu sunumu. İzmir Dr. Behçet Uz Çocuk Hast Dergisi. 2014;4:148-52.
  • 16. Miyahara M, Hirayama M. Kawasaki disease resembling acute colitis. BMJ Case Reports 2013. Doi:10.1136/bcr-2012-007384.
  • 17. Bagrul D, Karadeniz EG, Koca S. Gastrointestinal involvement in Kawasaki disease: a case report. Cardiol Young. 2018;28:1070-3.
  • 18. Kaman A, Aydın-Teke T, Gayretli-Aydın ZG, Öz FN, Akcan MÖ, Eriş D et al. Two cases of Kawasaki disease presented with acute febrile jaundice. The Turkish Journal of Pediatrics. 2017;59:84-6.
  • 19. Zulian F, Falcini F, Zancan L, Martini G, Secchieri S, Luzzatto C, Zacchello F. Acute surgical abdomen as presenting manifestation of Kawasaki disease.J Pediatr. 2003;142:731-5.
  • 20. Doksöz Ö, Özdemir R, Meşe T, Yozgat Y, Güven B. Kawasaki hastalığının nadir bir prezentasyonu; Hepatobiliyer tutulum: İki olgu sunumu. J Pediatr Inf. 2013;7:118-22.
  • 21. Göknar N, Doğan Demir A, Ataman Y, Gökalp S, Öktem F, Kasapçopur Ö. Artrit ve ikter ile başvuran Kawasaki olgusu. Bezmialem Science 2017;5:86-9.
  • 22. Eladawy M, Dominguez SR, Anderson MS, Glodé MP. Abnormal liver panel in acute kawasaki disease. Pediatr Infect Dis J 2011;30:141-4.
  • 23. Perera PJ, Samarasinghe D, Pathirana D, Randeni S, Samdamal LYS. An atypical case of Kawasaki disease presenting with cholestatic jaundice. Sri Lanka Journal of Child Health 2015;44(1):58-60.
  • 24. Garnett GM, Kimball S, Melish ME, Thompson KS, Puapong DP, Johnson SM et al. Appendicitis as the presenting manifestation of Kawasaki disease. Pediatr Surg Int. 2014;30:549-52.
  • 25. Trapani S, Montemaggi A, Simonini G, Calabri GB, Messineo A, Resti M. Surgical abdomen with intestinal pseudo-obstruction as presenting feature of atypical Kawasaki disease. Journal of Peadiatrics and Child Health. 2016:1-3.
  • 26. Behjati-Ardakani M, Ferdosian F. Multiple giant succular and fusiform right and left coronary artery aneurysms after early and adequate treatment of atypical Kawasaki disease with unusual presentation. Acta Med Iran. 2014;52:490-2.
  • 27. Paç Kısaarslan A, Sözeri B. Pediatrik romatoloji gözüyle Kawasaki hastalığına bakış. Türkiye Klinikleri J Pediatr. 2014;23:164-74.
  • 28. Dionne A, Dahdah N. Myocarditis and Kawasaki disease. Int J Rheum Dis. 2017;3:1-5.
  • 29. Ravekes WJ, Colan SD, Gauvreau K, Baker AL, Sundel RP, van der Velde ME et al. Aortic root dilation in Kawasaki disease. Am J Cardiol. 2001;87:919-22.
  • 30. O'Byrne ML, Cohen MS. Marked eosinophilia in a patient with history of severe atypical Kawasaki disease. Congenit Heart Dis. 2013;8:130-3.
  • 31. Ozdogu H, Boga C. Fatal cardiac tamponade in a patient with Kawasaki disease. Heart Lung. 2005;34:257-9.
  • 32. Okada S, Hasegawa S, Suzuki Y, Matsubara T, Shimomura M, Okuda M, Ichiyama T, Ohga S. Acute pericardial effusion representing the TNF-α-mediated severe inflammation but not the coronary artery outcome of Kawasaki disease. Scand J Rheumatol. 2015;44:247-52.
  • 33. Öztürk B, Tanır G, Kaman A, Gayretli Aydın ZG, Ertuğrul İ, Teke TA. Kawasaki hastalığı şok sendromu: Bir vaka takdimi. Çocuk Sağlığı ve Hastalıkları Dergisi. 2016;59:131-5.
  • 34. Yang HF, Chen WL, Chang CN, Chen SJ, Fan HC. Kawasaki disease shock syndrome: Case report. Paediatr Int Child Health. 2016;36:76-8.
  • 35. Chen PS, Chi H, Huang FY, Peng CC, Chen MR, Chiu NC. Clinical manifestations of Kawasaki disease shock syndrome: a case-control study. J Microbiol Immunol Infect. 2015;48:43-50.
  • 36. Sahoo S, Mandal AK. Congestive heart failure - an atypical presentation of Kawasaki disease. Iran J Pediatr 2012;22:428-9.
  • 37. Shah I. Kawasaki's disease: An unusual presentation. J Cardiovasc Dis Res. 2012;3:240-1.
  • 38. Natterer J, Perez MH, Di Bernardo S. Capillary leak leading to shock in Kawasaki disease without myocardial dysfunction. Cardiol Young. 2012;22:349-52.
  • 39. Kumar N, Mittal MK, Sinha M, Gupta A, Thukral BB. Unusual imaging presentation of infantile atypical Kawasaki disease. Indian J RadioImaging. 2016;26:373-6.
  • 40. Son MB, Newburger JW. Kawasaki disease. Pediatrics in Review. 2013;34:151-61.
  • 41. Tomita S, Chung K, Mas M, Gidding S, Shulman ST. Peripheral gangrene associated with Kawasaki disease. Clin Infect Dis. 1992;14:121-6.
  • 42. Pucci A, Martino S, Tibaldi M, Bartoloni G. Incomplete and atypical Kawasaki disease: a clinicopathologic paradox at high risk of sudden and unexpected infant death. Pediatr Cardiol. 2012;33:802-5.
  • 43. Javadzadegan H, Baghbani JM, Farhang S. Acute myocardial infarction as the first manifestation of the incomplete Kawasaki disease in a young male. Cardiology in the Young. 2009;19:635-7.
  • 44. Fulton DR, Newburger JW. Kawasaki disease. Ed. Keane JF, Lock JE, Fyler DC. Nadas’ Pediatric Cardiology. Philadelphia: Saunders Elsevier. 2006:401-13.
  • 45. Sumitomo N, Karasawa K, Taniguchi K, Ichikawa R, Fukuhara J, Abe O et al. ssociation of sinus node dysfunction, atrioventricular node conduction abnormality and ventricular arrhythmia in patients with Kawasaki disease and coronary involvement. Circ J. 2008;72:274-80.
  • 46. Torun Bayram M, Kır M, Kasap Demir B, Türkmen M, Soylu A, Kavukçu S. Akut piyelonefrit kliniği ile başvuran bir Kawasaki olgusu. Türk Çoc Hast Der. 2012;6:180-4.
  • 47. Büyükkaragöz B, Orak SA, Küçükkonyalı G, Köksal AO, Çaltık Yılmaz A, Özdemir O ve ark. İlk bulgusu steril piyüri olan bir Kawasaki hastalığı olgusu. Dicle Tıp Derg. 2015;42:390-3.
  • 48. Watanabe T. Kidney and urinary tract involvement in Kawasaki disease. Int J Pediatr 2013. doi: 10.1155/2013/831834.
  • 49. Anderson BL, Guiot AB, Timm NL. An atypical presentation of atypical Kawasaki disease. Pediatr Emerg Care. 2014;30:491-2.
  • 50. Chuang GT, Tsai IJ, Lin MT, Chang LY. Acute kidney injury in patients with Kawasaki disease. Pediatric Research. 2016;80:224-7.
  • 51. Álvarez EP, Rey F, Peña SC, Rubio A, Calvo C, Collado P. Has joint involvement lessened in Kawasaki disease? Reumatol Clin. 2017;13:145-9.
  • 52. Anderson BL, Guiot AB, Nathan LT. An atypical presentation oc atypical Kawasaki disease. Pediatr Emergency Care. 2014;30:491-2.
  • 53. Lee EY, Oh JY, Chong CY, Choo JT, Mahadev A, Tan NW. A Case of Atypical Kawasaki Disease With Myositis.Glob Pediatr Health. 2015:1-6.
  • 54. Nofech-Mozes Y, Garty BZ. Thrombocytopenia in Kawasaki disease: a risk factor for the development of coronary artery aneurysms. Pediatr Hematol Oncol. 2003;20:597-601.
  • 55. Palazzi DL, McClain KL, Kaplan SL. Hemophagocytic syndrome after Kawasaki disease. Pediatr Infect Dis J. 2003;22:663-6.
  • 56. Gültekingil A, Bayhan T, Kara A, Şahin M, Bilginer Y, Özen S. Kawasaki disease in two cousins with atypical presentation: Case report. Turkiye Klinikleri J Pediatr. 2010;19:347-9.
  • 57. Doğan V, Karaaslan E, Özer S, Gümüşer R, Yılmaz R. Hemophagocytosis in the acute phase of fatal Kawasaki disease in a 4 month-old girl. Balkan Med J. 2016;33:470-2.
  • 58. Latino GA, Manlhiot C, Yeung RS, Chahal N, McCrindle BW. Macrophage activation syndrome in the acute phase of Kawasaki disease.J Pediatr Hematol Oncol. 2010;32:527-31.
  • 59. Lee MN, Cha JH, Ahn HM, Yoo JH, Kim HS, Sohn S et al. Mycoplasma pneumoniae infection in patients with Kawasaki disease. Korean J Pediatr. 2011;54:123-7.
  • 60. Çakan M, Ayaz NA, Keskindemirci G, Genç HS, Bornaun H. İyileşmeyen pnömoni ile başvuran bir atipik Kawasaki hastalığı olgusu. Zeynep Kamil Tıp Bülteni. 2017:28-31.
  • 61. Yakut K, Ecevit Z, Varan B, Erdoğanİ, Gür Güngör S. Sıradışı bulgularla seyreden Kawasaki hastalığı: İki olgu. Turkiye Klinikleri J Pediatr. 2017;26:94-8.
  • 62. Adib A, Fazel A, Nabavizadeh SH, Alyasin S, Kashef S. Atypical desquamation in a 2.5-year-old boy with Kawasaki disease: A case report.Electron Physician. 2017;9:3764-7.
  • 63. Demir AD, Goknar N, Uzuner S, Vehapoglu A, Saritas T, Oktem F. The different cutaneous presentations in three cases of Kawasaki disease as confounding factorof diagnosis.J Pak Med Assoc. 2016;66:1188-90.
  • 64. Zhu H, Yu SF, Bai YX, Liang YY, Su XW, Pan JY. Kawasaki disease in children: Epidemiology, clinical symptoms and diagnostics of 231 cases in 10 years. Exp Ther Med. 2015;10:357-61.
  • 65. Kim JS, Kwon SH.Atypical Kawasaki disease presenting as a retropharyngeal abscess.Braz J Otorhinolaryngol. 2016;82:484-6.
  • 66. Ebrahim M, Gabay M, Rivas-Chacon RF. Evidence of acute Mycoplasma infection in a patient with incomplete and atypical kawasaki disease: a case report. Case Rep Med. 2011;1-4.
  • 67. Kanık A, Eliaçık K, Zengin N, Kuyum P, Kamit F, Bayram SN, ve ark. Menenjit kliniği ile gelen bir Kawasaki olgusu. İzmir Dr. Behçet Uz Çocuk Hast. Dergisi. 2011;1:137-9.
  • 68. Nomura Y, Arata M, Koriyama C, Masuda K, Morita Y, Hazeki D, Ueno K, Eguchi T, Kawano Y. A severe form of Kawasaki disease presenting with only fever and cervical lymphadenopathy at admission. J Pediatr. 2010;156:786-91.
  • 69. Yap CY, Lin LH, Wang NK. An atypical presentation of Kawasaki disease: a 10-year-old boy with acute exudative tonsillitis and bilateral cervical lymphadenitis. Clinics (Sao Paulo).2012;67:689-92.
  • 70. Kara SS, Güllü UU, Balaban İ. Kawasaki hastalığı: Erzurum ilinde izlenen çocuk hastaların değerlendirilmesi. İzmir Behçet Uz Çocuk Hast Dergisi. 2017;7:113-20.
  • 71. Garrido-García LM, López-Amézquita M, Villaverde-Rosas R.Kawasaki disease in a healthcare provider: an adult case in a paediatric resident.Cardiol Young. 2016;26:976-8.
  • 72. Kara A, Tezer H, Devrim İ, Kılıç Korkmaz E, Karagöz T, Özer S et al. Kawasaki disease: A case report in extreme of pediatrics. Infect Dis Clin Pract. 2006;14:333-4.
  • 73. Altunyuva Usta S, Akalın F. Ergenlikte Kawasaki hastalığı. Türk Ped Arş. 2013:169-72.
  • 74. Nakamura Y, Yashiro M, Uehara R, Watanabe M, Tajimi M, Oki I et al. Use of laboratory data to identify risk factors of giant coronary aneurysms due to Kawasaki disease. Pediatr Int. 2004;46:33-8.
  • 75. Maddox RA, Holman RC, Uehara R, Callinan LS, Guest JL, Schonberger LB et al. Recurrent Kawasaki disease: USA and Japan.Pediatr Int. 2015;57:1116-20.
  • 76. See XA, Prakash V, Tan KK. Recurrent Kawasaki disease presenting as acute airway obstruction.Singapore Med J. 2012;53:264-6.