Haydar Ali TAŞDEMİR, Deniz TEKİN, Recep SARAYMEN

The effects of antiepileptic drugs on serum and hair trace element levels

Amaç: Antiepileptik ilaçların serum ve saç eser element düzeylerini etkileyip etkilemediğini göstermek için epilepsi tanısı alan 40 çocuğu değerlendirdik. Gereç ve Yöntem: Serum Zn, Cu, Mg ile saç Zn düzeyleri fenobarbital veya valproik asit tedavisi başlanmadan önce ve 3 ay sonra değerlendirildi. Bulgular: Her iki tedavi ile de serum Zn düzeyleri düştü. Fenobarbital veya Valproik asit tedavisi alan epileptik hastalar karşılaştırıldığında, fenobarbital tedavisi alanlarda serum Zn düzeylerindeki düşme daha belirgindi. Sonuç: Hastalarımızın hiçbirinde Zn eksikliğine bağlı bulgular görmesek de, Fenobarbital veya Valproik asit tedavisi alan çocuklarda bu açıdan dikkatli olunmalıdır.When serum Zn levels were compared after VPA and PB therapies, those who received PB therapy were observed to have a less significant decrease in serum Zn level. Conclusion: Although none of our patients showed any symptoms of Zn deficiency, we should be cautious about this in patients who receive VPA and/or PB therapy.

Antiepileptik ilaçların serum ve saçta eser element düzeylerine etkileri

Aim: To assess whether antiepileptic drugs (AEDs) could affect serum and hair trace element levels, we studied 40 children with epilepsy. Materials and Methods: Their serum zinc (Zn), copper (Cu), magnesium (Mg) and hair Zn levels were measured by atomic absorption spectrophotometer prior to and 3 months after therapy with VPA (sodium valproate) or PB (phenobarbital). Results: In both treatments, epileptic children were found to have lower serum Zn concentrations.

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