Sinonasal low grade adenocarcinoma; A case report and the analysis of its histochemical and immunohistochemical characteristics

Sinonazal adenokarsinomalar (SA) lokal agresif tümörlerdir ve çoğunlukla orta ve ileri yaştaki erkeklerde görülür. Burun kanaması şikayeti ile başvuran 57 yaşındaki kadın hastanın endoskopik muayenesinde sol burun boşluğu ve paranazal sinüsleri tutan polipoid kitle lezyonu saptandı. Punç biyopsi düşük dereceli adenokarsinoma ile uyumluydu. Kitle total olarak çıkarıldı ve histopatolojik özellikleri punç biyopsininki ile benzerdi. Glandüler epitel hücreleri EMA, CK7, CK19, LMWCK ve S-100 için pozitifdi. Bulgular, sinonasal mukozadan kaynaklanan düşük dereceli adenokarsinoma ile uyumluydu. Total eksizyon sonrası 20. ayda hastada nüks gelişmedi. SA değişken klinik davranış ve farklı epidemiyolojik özellikler ile karakterli heterojen bir grup neoplazmdır. Ayırıcı tanıda, bir çok tümor ve tümor benzeri lezyon hesaba katılmalıdır. Bu lezyonlar arasındaki ayırıcı tanı nüks riski nedeniyle önemlidir.

Sinonazal düşük dereceli adenokarsinoma; Bir olgu sunumu ve histokimyasal / immünohistokimyasal özelliklerin analizi

Sinonasal adenocarcinomas (SAs) are local aggressive tumors and occur in middle and advanced aged male patients. A polypoid mass involving to the left nose and paranasal sinuses was determined in endoscopical examination of a 57-year-old female patient admitting with epistaxis. Punch biopsy revealed a low grade adenocarcinoma. The mass was totally excised and its histopathological features were similar to punch biopsy. Glandular epithelium was positive for EMA, CK7, CK19, LMWCK and S-100. The findings were concordant with a low grade adenocarcinoma originating from sinonasal mucosa. No recurrence was determined 20 months after total excision. SAs are a heterogenous group of neoplasms characterizing by variable clinical behavior and different epidemiological features. In the differential diagnosis, many tumoral and tumor like lesions should be considered. The differential diagnosis is very important because of the risk of recurrence.

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