Recep ÖZTÜRK, Burak BAHADIR, Ercan BAL, Ömer Faruk TÜRKOĞLU, Mahmut Nedim AYTEKİN

Santral Sinir Sistemi Teratomlarının SEER Veritabanında Epidemiyolojik Analizi

Amaç: Teratomlar, santral sinir sisteminin nongernimomatöz germ hücreli tümörlerindendir. Bu çalışmanın amacı santral sinir sistemi teratomlarınınepidemiyolojik özelliklerini incelemek idi.Gereç ve Yöntem: Amerika Birleşik Devleti Ulusal Kanser Enstitüsü (Surveillance, Epidemiology, and End Results Program) (SEER) veritabanıkulanılarak santral siniri sistemi teratomları dekadlara ve lokalizasyonuna göre ayrıldı ve istatistiksel olarak demografik veriler retrospektif olarakanaliz edildi.Bulgular: Teratom tanısı alan 422 hasta SEER veri tabanında bulunmuştur. Hastaların %69’unun (n=293) benign, %31’inin (n=129) malign histolojikkarakterde olduğu tespit edilmiştir. Malign teratomların %87,6’sı (n=113/129) ilk iki dekadda görülmektedir. Benign teratomların ise %56,7’si(n=166/293) hayatın ilk 3 dekadında görülmektedir Beynin lobları arasında en sık frontal lobda (%9,7) yerleşmektedir. Teratomların pineal bölgedebulunma oranı %16,4 olarak bulunmuştur.Sonuç: Teratomlar en sık ilk iki dekadda görülürler ve tüm teratomların yaklaşık üçte ikisi benigndir. Teratomlar beyin loblarından en sık frontal lobayerleşme eğiliminde iken, en sık ekstraaksiyel yerleşim yeri pineal glanddır.

Epidemiological Analysis of Central Nervous System Teratomas in SEER Database

Objectives: Teratomas are nongernimmatomatous germ cell tumors of the central nervous system. The aim of this study was to investigate the epidemiological features of central nervous system teratomas. Materials and Methods: Central nervous system teratomas were separated according to decades and localization using the United States National Cancer Institute [Surveillance, Epidemiology, and End Results Program (SEER)] database and demographic data were statistically analyzed retrospectively. Results: Four hundred and twenty-two patients diagnosed with teratoma were found in the SEER database. It was determined that 69% (n=293) of the patients had benign and 31% (n=129) had a malignant histological character. 87.6% (n=113/129) of malignant teratomas were detected in the first two decades. 56.7% (n=166/293) of benign teratomas were found in the first 3 decades of life. Among the lobes of the brain, teratomas are most frequently located in the frontal lobe (9.7%). The rate of teratomas in the pineal region was found to be 16.4%. Conclusion: Teratomas are frequently seen in the first two decades and approximately two-thirds of all teratomas are benign. While teratomas tend to localize from the brain lobes to the frontal lobe, the most common extra-axial localization is the pineal gland.

PDF

___

1. McCarthy BJ, Shibui S, Kayama T, et al. Primary CNS germ cell tumors in Japan and the United States: an analysis of 4 tumor registries. Neuro Oncol. 2012;14:1194-1200.
2. Denyer S, Bhimani AD, Patil SN, et al. Treatment and survival of primary intracranial germ cell tumors: a population-based study using SEER database. J Cancer Res Clin Oncol. 2020;146:671-685.
3. Sun H, Ding H, Wang J, et al. The differences between gonadal and extra-gonadal malignant teratomas in both genders and the effects of chemotherapy. BMC Cancer. 2019;19:408.
4. Louis DN, Ohgaki H, Wiestler OD, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007;114:97- 109.
5. Murray MJ, Bartels U, Nishikawa R, et al. Consensus on the management of intracranial germ-cell tumours. Lancet Oncol. 2015;16:e470-e477.
6. Tsuyuguchi S, Sugiyama K, Kinoshita Y, et al. Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature. World Neurosurg. 2020;134:e360-e71.
7. Lee YH, Park EK, Park YS, et al. Treatment and outcomes of primary intracranial teratoma. Childs Nerv Syst. 2009;25:1581-1587.
8. Fetcko K, Dey M. Primary Central Nervous System Germ Cell Tumors: A Review and Update. Med Res Arch. 2018;6.
9. Matsutani M, Sano K, Takakura K, et al. Primary intracranial germ cell tumors: a clinical analysis of 153 histologically verified cases. J Neurosurg. 1997;86:446-455.
10. Ogawa K, Toita T, Nakamura K, et al. Treatment and prognosis of patients with intracranial nongerminomatous malignant germ cell tumors: a multiinstitutional retrospective analysis of 41 patients. Cancer. 2003;98:369-376.
11. Gittleman H, Cioffi G, Vecchione-Koval T, et al. Descriptive epidemiology of germ cell tumors of the central nervous system diagnosed in the United States from 2006 to 2015. J Neurooncol. 2019;143:251-260.
12. Echevarria ME, Fangusaro J, Goldman S. Pediatric central nervous system germ cell tumors: a review. Oncologist. 2008;13:690-699.
13. Kuratsu J, Ushio Y. Epidemiological study of primary intracranial tumors in childhood. A population-based survey in Kumamoto Prefecture, Japan. Pediatr Neurosurg. 1996;25:240-246.
14. Goodwin TL, Sainani K, Fisher PG. Incidence patterns of central nervous system germ cell tumors: a SEER Study. J Pediatr Hematol Oncol. 2009;31:541-544.
15. Villano JL, Propp JM, Porter KR, et al. Malignant pineal germ-cell tumors: an analysis of cases from three tumor registries. Neuro Oncol. 2008;10:121- 130.
16. Alexander VR, Manjaly JG, Pepper CM, et al. Head and neck teratomas in children--A series of 23 cases at Great Ormond Street Hospital. Int J Pediatr Otorhinolaryngol. 2015;79:2008-20014.