Onat BERMEDE, Bülent Mustafa YENİGÜN, Sacide DEMİRALP

Tek Akciğer Ventilasyonu Uygulanan Hastalarda Sevofluran ve Propofolün Pulmoner Oksidatif Stres Üzerine Etkisi

Amaç: Akciğer rezeksiyonu sırasında opere edilen akciğerin kollabe edilip daha sonra reekspanse edilmesi ile iskemi-reperfüzyon hasarı için idealortam oluşturulur. Bu operasyonlar esnasında kullanılan anestezik ajanlar oksidatif stres üzerinde belirleyici olabilirler. Bu çalışmada tek akciğerventilasyonu (TAV) ile lobektomi yapılan hastalarda propofol ile sevofluranın oksidatif stres bakımından karşılaştırılması planlandı.Gereç ve Yöntem: Akciğer kanseri nedeniyle elektif lobektomi planlanan 28 hasta çalışmaya dahil edildi. Grup P’de (propofol) anestezi idamesi 5-10mg kg-1 st-1 propofol ve 0.1-0.2 μg kg-1 dk-1 remifentanil infüzyonu ile sağlanırken, grup S’de (sevofluran) %1-3 sevofluran kullanıldı. Başlangıçta,TAV sonlandırılmadan önce pulmoner venden ve periferik venden, TAV sonrası 20. dakika venöz kan örnekleri alındı.Bulgular: Her iki grupta plazma malondialdehit değerlerinde bazal değere göre artış tespit edildi (p

The Effect of Sevoflurane and Propofol on Pulmonary Oxidative Stress in Patients Undergoing Single Lung Ventilation

Objectives: Collapsing and re-expanding the operated lung during lung resection create the ideal condition for ischemia-reperfusion injury. Anesthetic agents used during these operations may be determinative on oxidative stress. In this study, we aimed to compare propofol with sevoflurane in terms of oxidative stress in patients undergoing lobectomy with single lung ventilation (SLV). Materials and Methods: Twenty-eight patients undergoing elective lobectomy for lung cancer were included in the study. Anesthesia was maintained with 5-10 mg kg-1 st-1 propofol and 0.1-0.2 μg kg-1 min-1 remifentanil infusion in group P (propofol), while 1-3% sevoflurane was used in group S (sevoflurane). Peripheral venous blood at baseline, pulmonary venous and peripheral venous blood before SLV lung ventilation was terminated and peripheral venous blood samples 20 minutes after SLV were obtained. Results: In both groups, plasma malondialdehyde levels increased compared to baseline (p

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