Overin Seröz Adenokarsinomları ve Seröz Borderline Tümörlerinde RAS/RAF/MEK/MAPK Yolağındaki Moleküler Değişikliklerin Araştırılması

Amaç: Overin yüksek dereceli seröz adenokarsinomları, seröz borderline tümörleri ve benign lezyonlarında RAS/RAF/MEK/MAPK yolağında değişikbasamaklarda olduğu bildirilen moleküller; MAP Kinaz (p38), c-Fos, c-Jun ve c-Myc’in immünhistokimyasal olarak araştırılması amaçlanmıştır.Gereç ve Yöntem: On iki seröz borderline tümör, 41 yüksek dereceli seröz karsinom ve seröz papiller kistadenofibrom, seröz kistadenomlardan oluşan19 olgu ile birlikte, toplam 72 olgu üzerinde p38, c-Myc, c-Jun ve c-Fos immünhistokimyasal boyamaları yapılmıştır.Bulgular: c-Fos ile bordeline ve benign lezyonlarda olguların tamamında yaygın ve şiddetli boyanma izlenirken, seröz adenokarsinomların yalnızca16’sında fokal ve hafif boyanma izlenmiştir (p

Investigation of Molecular Changes in RAS/RAF/MEK/MAPK Pathway in Serous Adenocarcinomas and Serous Borderline Tumors of Ovary

Objectives: To investigate MAP Kinase (p38), c-Fos, c-Jun and c-Myc; in RAS/RAF/MEK/MAPK pathway by immunohistochemically in high grade serous adenocarcinomas, serous borderline tumors and benign lesions of the ovary. Materials and Methods: Twelve serous borderline tumors, 41 high-grade serous carcinomas and 19 cases of serous papillary cystadenofibromas, serous cystadenomas; p38, c-Myc, c-Jun and c-Fos immunohistochemical staining were performed. Results: In borderline and benign lesions, diffuse and severe staining was observed in all cases with c-Fos, whereas focal and mild staining was observed in only 16 of the serous adenocarcinomas (p

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