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• 1. Saunders WB. editor. Guyton & Hall Tıbbi Fizyoloji. İstanbul: Nobel Tıp Kitabevi, 1996; p.886. 2. Champe PC, Harvey RA. editors. Lippincott’s Biyokimya. İstanbul:Nobel Tıp Kitabevi, 1997; p. 210-213. 3. Reichen J. Theroleofthesinusoidalendotheliuminliverfunction.News Physiol. Sci. 1999; 14:117-21. 4. Feldman M, Schorschmidt BF, Sleiseger MH. editors. Gastrointestinal and Liver Disease. Pheladelphia/London:Saunders, 1998; p.937-48. 5. Meier PJ. Molecular mechanisms of hepatic bile salt transport from sinusoidal blood into bile. Am. J. Physiol. Gastrointest. Liver Physiol. 1995; 269:G801-G12. 6. Groothuis GM, Hardonk MJ, Keulemans KP et al. Autoradiographic and kinetic demonstration of acine heterogeneity of taurocholate transport. Am.J.Physiol. Gastrointest. Liver Physiol. 1982; 243:G455-G62. 7. Hagenbuch B, Steiger B, Foguet M et al. Functional expression cloning and characterization of the hepatocyte Na/bile acid co-transport system. Proc. Natl. Acad. Sci. USA.1991; 88:10629-33. 8. Cattori V, Eckhardt U, Hagenbuch B. Molecular cloning and fonctional characterization of two alternatively sliced Ntcp isoforms from Mouse liver. Biocim. Biophys. Acta. 1999; 1445:154-59. 9. Kramer W, Stengelin S, Baringhaus KH et al. Substrate specificityof the ileal and the hepatic Na/bile acid cotransporters of the rabbit 1. transport studies with membrane vesicles and cell lines expressing the cloned transporters. J. Lipid Res. 1999; 40:1604-17. 10. Hagenbuch B, Meier PJ. Molecular cloning chromosomal localization and function characterization of human liver Na/bile acid cotransporter. J. Clin. Invest. 1994; 93:1326-31. 11. Meier PJ, Eckhardt U, Schroder A, et al. Substrate specificityofsinusoidal bile acid and organic anion uptake systems in rat and human liver. Hepatology. 1997; 26:1667-77. 12. Hardikar W, Anonthanarayenan M, Suchy FJ. Differantialoncogenic regulation of basolateral and canalicular bile acid transport proteins in rat liver. J. Biol. Chem. 1995; 270:20841-46. 13. Suchy FJ, Bucuvalas JC, Goodrich AL et al. Taurocholate transport and Na-K-ATP ase activity in fetal and liver plasma membrane vesicles. Am. J. Physiol. Gastrointest. Liver Physiol. 1986; 251:G665-73. 14. Gren RM, Gollon JL, Hagenbuch B, et al. Regulation of hepatocyte bile salt transporters diving hepatic regeneration. Am.J.Physiol.Gastrointest. Liver Physiol. 1997; 273:G621-G27. 15. Hagenbuch B. Scharschmidt BF, Meier PJ. Effectofantisenseoligonucleotides on the expression of hepatocellular bile acid and organic anion uptake systems in Xenopus laevis oocytes. Biochem.J. 1996; 316:901-4 16. Keng VW, Yagi H, Ikvva M, et al. Homebox gene Hex is essential for onset of Mouse embrionic liver development and differentiationof the monocyte lineage. Biochem. Biophys. Res. Common. 2000; 276:1155-61 17. Traziner M, Arrese M, Lee YH et al. Endotoxin downregulates rat hepatic Ntcp gene expression via decreased activity of critical transcription factors. J.Clin.Invest. 1998; 101:2092-100. 18. Shih DQ, Busen M, Sehayek E et al. Hepatocyte nuclear factor-lx is an essential regulator of bile acid and plasma cholesterol metabolism. Nat.Genet. 2001; 27:375-82 19. Hayhurst GP, Lee YH, Lambert G et al. Hepatocyte nuclear factor 4 x (nuclear factor 2 A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol.Cell.Biol. 2001; 21:1393-403. 20. Rausa FM, Tan Y, Zhou H et al. Elevated levels of hepatocyte nuclear factor 3B in mouse hepatocytes influenceexpressionofgenes involved in bile acid and glucose homeostasis. Mol. Cell. Biol. 2000; 20:8264-82. 21. Sinal CJ, Tohkin M, Miyata M et al. Targeted disruption of the nuclear receptor FXR / BAR impairs bile acid and lipid homeostasis. Cell. 2000; 102:731-44. 22. DranoffJA,McClureM,BurgstahlerAD et al. Short term regulation of bile acid uptake by microfilament–dependenttranslocation of rat Ntcp to the plasma membrane. Hepatology. 1999; 30:223-29. 23. M. Trauner. Genetic disorders and molecular mechanism in cholestatic liver disease. Semin. Gastrointest. Dis. 2001; 12:66-88. 24. Glawy JS, Wu SM, Wang PJ et al. Down-regulation by extracellular ATP of rat hepatocyte organic anion transport is mediated by serine phosphorylation of Oatp1. J.Biol.Chem. 2000;275:1479-84. 25. Lee JL, Boyer JL. Molecular alterations in hepatocyte transport mechanism in acquired cholestatic liver disorders. Semin.Liver Dis. 2000;20:373-84. 26. CuimY, König J, Leier I et al. Hepatic uptake of bilinubin and its conjugates by the human organic anion transporting polipeptide SLC 21A6. J.Biol.Chem. 2001;276:9626-30. 27. Kullack-Ublick GA, Beuers U, Fahney C et al. Identificationandfunctional characterization of the promoter region of the human organic anion transporting polypeptide gene. Hepatology. 1997;26: 991- 997. 28. König J, Rost D, Cui Y et al. Characterization of the human multidrug resistance protein isoform MRP-3 localized to the basolateral hepatocyte membrane. Hepatology. 1999;29:1156-63. 29. Wilton JC, Mattheus GM, Burgoyre RD et al. Flourescent choleretic and bile salt take differentpathsacrossthehepatocyte:transcytosisofglycolithocholate leads to on extensive redistribution of annexin II. J.Cell Biol. 1994; 127:401-10. 30. El Seaidy AZ, Mills CO, Elias E et al. Lack of evidence for vesicle traffickingofflourescentbilesaltsin rathepatocytecouplets.Am.J.Physiol. Gastrointest. Liver Physiol. 1997;272:G298-G309. 31. Strautnikes SS, Bull LN, Knisely AS et al. A gene encoding a liver-spesificABCtransporterismutadedinprogressivefamilialintrahepatic cholestasis. Nat.Genet. 1998;20:233-38. 32. Wang R, Salem M, Yousef IM et al. Targeted inactivation of sister of P-glycoprotein gene (spgp) in mice results in nonprogressive but persistent intrahepatic cholestasis. Proc.Natl.Acad.Sci.USA. 2001;98:2011-16. 33. Stieger B, Fattinger K, Madon J et al. Drug and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump of rat liver. Gastroentorology. 2000;118:422-30. 34. Kartenbeck J, Leuschner U, Mayer R et al. Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson Syndome. Hepatology. 1996; 23:1061-6. 35. De Vree JM, Jacquemin E, Sturm E et al. Matation in the MDR 3 gene cause progressive familial intrahepatic cholestasis. Proc.Natl.Acad.Sci.USA. 1998;95:282-87. 36. Kamisako T, Kobayashi Y, Takeuchı K et al. Recent advances in bilirubin metabolism research: the molecular mechanism of hepatocyte bilirubin transport and its clinical relevance. J. Gastroenterol. 2000; 35:659-664. 37. Meier PJ, Stieger B. Bile salt transporter. Annu. Rev. Physiol. 2002; 64:635-61. 38. Takikawa H. Hepatobiliary transport of bile acids and organic anions. J. Hepatobiliary Pancreat. Surg. 2002; 9:443-447. 39. Trauner M, Boyner JL. Bile salt transporters: molecular characterization, function, and regulation. Physiological Reviews. 2003,83(2).633-71.