Oya TEKELİ, Hüseyin TUTKAK, M. Erol TURAÇLI, Filiz A. ÖZDEMİR

Psödoeksfolyasyonlu Türk hastalarda HLA Class I antijenleri

Amaç: Türk popülasyonunda psödoeksfolyasyon ile human leucocyte antigens (HLA) class I antijenleri arasındaki korelasyonu saptamak. Gereç ve Yöntem: En az bir gözünde psödoeksfolyasyonu olan 76 hasta ile psödoeksfolyasyonu olmayan 100 olguda HLA class I antijenleri incelendi. Bulgular: Psödoeksfolyasyon grubunda HLA A68, B39, CW4 istatistiksel olarak daha sık saptanırken HLA A1, B7 istatistiksel olarak daha az sıklıkta bulundu. Psödoeksfolyasyon ve kontrol grubunda haplotip frekansı açısından istatistiksel olarak belirgin bir fark saptanmadı. Sonuç: Farklı populasyonlar ve hasta akrabalarında yapılacak yeni çalışmalar psödoeksfolyasyon ile HLA arasındaki ilişkinin belirlenmesinde yardımcı olacaktır.

HLA Class I antigens in Turkish patients with pseudoexfoliation

Aim: To asses whether a correlation exists between Human Leucocyte Antigens (HLA) class I antigens and pseudoexfoliation in Turkish population. Materials and Methods: The HLA class I antigens were analyzed in 76 patients with pseudoexfoliation at least at one eye and in 100 subjects without pseudoexfoliation. Results: HLA A68, B39, CW4 were significantly more common in pseudoexfoliation than control group, while HLA A1, B7 were significantly less common. No statistically significant difference was noted in antigen frequencies of pseudoexfoliation and control group. Conclusion: Further studies on more diverse ethnic populations and patient’s relatives will be helpful in determining the significance of the association between certain HLA and disease susceptibility.

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