Karaciğer metastazı ile prezente olan paraganglioma olgusunda sitolojik özellikler (Metastatik paraganglioma sitolojisi)

Retroperitoneal paragangliomalar nadir görülen nöroen-dokrin tümörlerdir. Bu tümörler sessiz bir klinik seyir göstermekle birlikte, ilk tanıdan sonraki 7-33 yıl içinde metastazlar ortaya çıkabilir. Metastazla prezentasyon ise çok nadir görülen bir durumdur. Paragangliomaların tanısında ince iğne aspirasyonu (IIA) değerli bir yöntem olmakla birlikte bu, tümörün oldukça nadir görülmesi nedeni ile güç olabilir. Burada karaciğerde kitle ile prezente olan nadir bir paraganglioma olgusuna ait sitolojik ve histopatolojik özellikler sunulmaktadır.

Cytologic features of a paraganglioma case presenting with liver metastases

Retroperitoneal paragangliomas are uncommon neuroendocrine tumors. Although they have indolent clinical course, metastases may develop 7-33 years after the initial diagnosis. But presentation with a metastases is a very ra-re condition. Fine needle aspiration biopsy (FNA) is valuable in the diagnosis of these tumors, but it may be difficult due to the infrequent occurence of this neoplasm. Here we repon the cytologic and histopathologic features of a rare retroperitoneal paraganglioma case which is presented with a liver mass.

___

  • 1. Lack EE, Cubilla AL, Woodruff JM, Lieberman PA: Extraadrenal paraganglioma of the retroperitoneum. Am J Surg Pathol 1980; 4:109-120
  • 2. Sclafani LM, Woodruff JM, Brennan MF: Extraadre nal retroperitoneal paragangliomas: Natural history and response to treatment. Surgery 1990, 108:1124- 1130
  • 3. Linnoila Rl, Keiser HR,Steinberg SM, Lack EE: Histo- pathology of benign versus malignant sympathoad- renal paragangliomas: Clinicopathologic study of 120 cases including unusual histologic features. Hum Pathol 1990;21:1168-1180
  • 4. O'Riordain DS, Young WF, Grant CS, Carney JA, VanHeerden JA: Clinical spectrum and outcome of functional extraadrenal paraganglioma. World J Surg 1996;20:916-922
  • 5. Odze R, Begin LR: Malignant paraganglioma of the posterior mediastinum: A case report and review of the literature. Cancer 1990,65:564-569
  • 6. Vera-Alvarez J, Marigil-Gomez M, Abascal-Agorreta M, Vasquez-Garcia J. Malignant retroperitoneal pa- raganglioma with intranuclear vacuoles in a fine ne- edle aspirate. Acta Cytologica 1993;37:229-233.
  • 7. Absher KJ, Witte DA, Truong LD, Ramzy I, Mody DR, Ostrowski ML. Aspiration biopsy of ossseous metastasis of retroperitoneal paraganglioma. Acta Cytologica 2001; 45: 249-253.
  • 8. Kim MY, Park SH, Cho HD, Cho SJ, Kim A, Kim HK, Yeom BW, Choi JS, Kim CH. Fine needle aspiration cytology of primary pulmonary paraganglioma. Ac- ta Cytologica 2001, 45:459-464
  • 9. Rupp M, Ehya H. Fine needle aspiration cytology of retroperitoneal paraganglioma with lipofussin pig- mentation. Acta Cytologica 1990; 34: 84-88.
  • 10. Shidham VB, Galindo LM. Pheochromocytoma Cytologic findings on intraoperative scrabe smears in five cases. Acta Cytologyca 1999;43:207-213