Nevzat ILIMAN, Halime KÜÇÜKYILMAZ, Ateş Yasemin TÜTÜNCÜ, Utku SERKANT, Erdem AKBAL, Mehmet YILDIZ

Hipotiroidi ve hipertiroidi ile pulmoner hipertansiyon arasındaki ilişkinin incelenmesi

Amaç: Tiroid hormonları vücutta hemen hemen tüm sistemleri etkileyen hormonlardır. Tiroid hormonlarının kardiovasküler etkileri uzun zamandır bilinmektedir. Ancak tiroid hormonlarının solunum sistemi ve pulmoner dolaşım üzerine etkileri ayrıntılı olarak incelenmemiştir. Bu çalışmada, hem hipotiroidinin, hem de hipertiroidinin pulmoner hipertansiyon üzerine etkisi olup olmadığı ayrıca tiroid hastalıkları ile birlikte görülen pulmoner hipertansiyonda otoimmünitenin rolü olup olmadığı araştırıldı. Gereç ve yöntem: Bu çalışmaya hipotiroidi tanısı alan 25 hasta, hipertiroidi tanısı alan 27 hasta ve tamamen sağlıklı 25 kişiden oluşan kontrol grubu alındı. Hasta grubana tedaviye başlanmadan önce ve başlandıktan sonra ekokardiogtafi (EKO) yapılarak pulmoner arter basıncı ölçüldü. Bulgular: Hipotiroidi tanısı alan 25 hastada tedaviden önce pulmoner arter basıncı ortalama 44.86 ± 11.8 mmHg olup, tedaviden sonra ise pulmoner arter basıncı 27.54 ± 9.5 mmHg olarak ölçüldü. Hipertiroidili hastalarda tedaviden önce pulmoner arter basıncı 40.30 ± 8.7 mmHg idi.Tedaviden sonra ise pulmoner arter basıncı 25.54 ±5.3 mmHg olarak ölçüldü. Buna karşılık kontrol grubunda pulmoner arter basıncı 21.74 ± 6.8 mmHg idi. Sonuç: Patogenezi açık olmamakla birlikte hem hipotiroidili hem de hipertiroidili hastalarda pulmoner arter basıncının artmış olduğu saptanmıştır. Tedavi ile tiroid disfonksiyonu düzeltildiğinde pulmoner arter basıncının düştüğü gözlenmiştir.

The relation between pulmonary hypertension, hypothyroidism and hyperthyroidism

Aim:Thyroid hormons affect all the systems in the organism. Cardiovascular effects of the thyroid hormons are known for a long time. But their effects on the pulmonary circulation and respiratory system have not been invastigated. In this paper the effect of thyroid hormones on the pulmo-nary artery pressure has been investigated. Materials and methods: In this paper, we have investigated pulmonary hypertension in 25 pa-tients with hypothyroidism and 27 patients with hyperthyroidism and 25 healthy men. Pulmo-nary artery pressure has been measured in the patients with hypothyroidism and hyperthyroid-ism before and after treatment. Results: Pulmonary artery pressure was 44.86 ±11.8 inthe patients with hyperthyroidism before the treatment. It has been measured the pulmonary artery pressure after the treatment. It was 27.54 ± 9J5 mmHg; Before the treatment pulmonary artery pressure was 40.30 ± 8.7 mmHg in patients with hyperthyroidism. After the treatment it was 25.54 ± 5.3. In control group pulmonary artery pressure was 21.74 ± 6.9. Conclusion: It has been found that pulmonary artery pressure is augmented despite the patho-genesis of the pulmonary hypertension at the thyroid disease isn't clear. In both hypothyroidism and hyperthyroidism when the dysfunctions of thyroid disorders are treated, pulmonary artery pressure return to normal.

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