Aysun GENÇ, Alpay AZAP, Emin TEKELİ, Hande AYGÜN, Serpil ÖZKAN, Osman MEMİKOĞLU, Yılmaz Gülden BOZKURT, Hüseyin ŞAHİNTÜRK

Fusidik asidin Staphylococcus aureus suşlarına karşı in-vitro etkinliği

Amaç: Bu çalışmada klinik örneklerden izole edilen ve enfeksiyon etkeni olarak kabul edilen 440 Staphylococcus aureus susunun fusidik asite in-vitro duyarlılığı araştırılması amaçlandı. Gereç ve yöntem: "National Committee for Clinical Laboratory Standards" (NCCLS) önerileri doğ-rultusunda agar dilüsyon yöntemi ile minimal inhibitor konsantrasyon (MİK) değerleri belirlendi. MİK değeri ≥2 mg/L olan suşlar dirençli, sO.125mg/L olan suşlar duyarlı kabul edildi. Bulgular: Çalışmaya alınan 196 metisiline duyarlı S.aureus susunda fusidik asite direnç saptanmazken, 244 metisiline dirençli S.aureus susundan 2'si (%0.8) fusidik asite dirençli bulundu. Sonuç: Fusidik asit, metisiline dirençli ve duyarlı stafilokokların etken olduğu enfeksiyonlarda iyi bir tedavi seçeneği olarak karşımıza çıkmaktadır

In-vitro activity of fusidic acid against Staphylococcus aureus

Aim: This study was undertaken to investigate the in vitro susceptibility of Staphylococcus aureus strains to fusidic acid. Materials and methods: A total of 440 strains isolated from various clinical specimens were in-cluded in the study. The susceptibility tests were performed by agar dilution method acccording to the NCCLS (National Committee for Clinical Laboratory Standards) criteria. Strains with MIC value of a2 mg/L were taken as resistant to fusidic acid. Results: None of the methicillin-susceptible S.aureus (MSSA) strains were found to be resistant while 2 (0.8%) of 244 methicilliriresistant S.aureus (MRSA) strains were resistant to fusidic acid. Conclusion: Fusidic acid can be considered as an alternative drug for the treatment of infections due to both methicillin susceptible and resistant S.aureus strains.

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