YENİ NESİL LİPİT BAZLI İLAÇ TAŞIYICI SİSTEMLER: LİPİT NANOKAPSÜLLER

Amaç: Nanopartiküler ilaç taşıyıcı sistemler, boyuta bağlı özelliklerinden dolayı giderek artan şekilde ilgi görmektedir. Bu sistemler arasında polimerik nanopartiküller ve lipozomlar en popüler nanotaşıyıcılardandır; ancak bu sistemlerde görülen düşük stabilite, kısa raf ömrü, hazırlanmasında organik çözücü kullanımı, ölçek büyütmenin zor olması gibi dezavantajların üstesinden gelmek için araştırmacılar lipit bazlı nanotaşıyıcılara yönelmiştir. Yeni nesil lipidik taşıyıcılardan olan lipid nanokapsüller (LNC), hidrofilik ve lipofilik sert bir surfaktan kabuk ile çevrelenmiş yağlı sıvı çekirdekten oluşan sistemlerdir ve polimerik nanokapsüller ile lipozomlar arasında yer alan hibrit bir yapıya sahiptirler. Bu derleme kapsamında LNC’ler hakkında genel bilgiler, hazırlama yöntemi ve uygulama yollarına ilişkin bilimsel çalışmalar sunulmuştur.

Anahtar Kelimeler:

Lipit bazlı ilaç taşıyıcı sistemler, lipit nanokapsüller, faz inversiyon yöntemi

NEW GENERATION LIPID-BASED DRUG DELIVERY SYSTEMS: LIPID NANOCAPSULES

Objective: Nanoparticulate drug delivery systems are attracting increasing attention due to their size-dependent properties. Among these systems, polymeric nanoparticles and liposomes are the most popular nanocarriers, but to overcome the disadvantages such as low stability, short shelf life, use of organic solvents in preparation, and difficulty in scale-up, researchers have turned to lipid-based nanocarriers. Lipid nanocapsules (LNCs), one of the new generation lipidic carriers, are nanoparticular systems consisting of an oily liquid core surrounded by a hydrophilic and lipophilic rigid surfactant shell. Their structure is a hybrid nature between liposomes and polymeric nanocapsules. In this review, general information about LNCs, preparation method and scientific studies on application methods are presented.

Keywords:

Lipid-based drug delivery systems, lipid nanocapsules, phase inversion process,

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