TIP VE ECZACILIK ALANINDAKİ 1,2,4-TRİAZOL TÜREVLERİ VE UYGULAMA ÖNERİLERİ
Amaç: 1,2,4-triazol türevlerinin,özellikle heterosiklik iskelete sahip ve biyolojik olarak aktif bileşiklerin, sentezi, kimyasal, fizikokimyasal ve biyolojik özelliklerinin incelenmesi için yöntemlerin geliştirilmesi.
1,2,4-TRIAZOLE DERIVATIVES IN MEDICINE AND PHARMACY AND APPLICATION PROSPECTS
Objective: Development of methods for the synthesis, studies of chemical, physico-chemical and biological properties of 1,2,4-triazole derivatives, in particular compounds with heterocyclic scaffolds and complex compounds as potential biologically active substances.
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- 1. Khan, S., Imam, S., Ahmad, A., Basha, S., Husain, A. (2018). Synthesis, molecular docking with COX 1& II enzyme, ADMET screening and in vivo anti-inflammatory activity of oxadiazole, thiadiazole and triazole analogs of felbinac. Journal Of Saudi Chemical Society, 22(4), 469-484. [CrossRef]
- 2. Barbuceanu, S., Draghici, C., Barbuceanu, F., Bancescu, G., Saramet, G. (2015). Design, synthesis, characterization and antimicrobial evaluation of some heterocyclic condensed systems with bridgehead nitrogen from thiazolotriazole class. Chemical And Pharmaceutical Bulletin, 63(9), 694-700. [CrossRef]
- 3. Mioc, M., Avram, S., Bercean, V., Kurunczi, L., Ghiulai, R. M., Oprean, C., Soica, C. (2018). Design, synthesis and biological activity evaluation of S-substituted 1H-5-mercapto-1,2,4- triazole derivatives as antiproliferative agents in colorectal cancer. Frontiers in chemistry, 6, 1- 19. [CrossRef]
- 4. Nastasă, C., Vodnar, D., Ionuţ, I., Stana, A., Benedec, D., Tamaian, R., Onica, O., Tiperciuc, B. (2018). Antibacterial evaluation and virtual screening of new thiazolyl-triazole schiff bases as potential DNA-gyrase inhibitors. International Journal of Molecular Sciences, 19(1), 222. [CrossRef]
- 5. Karbalaei, M., Seifi, M., Sheibani, H. (2014). Regioselective ring opening of 2,2-dicyanooxiranes by 1,3-dinucleophiles in the presence of Lewis acids such as bismuth(III) nitrate pentahydrate [Bi(NO3)3·5H2O] and zirconium(IV) chloride (ZrCl4). Research on Chemical Intermediates, 41(7), 4679-4686. [CrossRef]
- 6. Ur-Rehman, A., Nafeesa, K., Athar Abbasi, M., Zahra Siddiqu, S., Rasool, S., Adnan Ali Shah, S., Ashraf, M., Lodhi, M.A., Khan, F.A., Jahan, B. (2018). S-substituted derivatives of 1,2,4- triazol-3-thiol as new drug candidates for type II diabetes. Turkish Journal of Chemistry, 42(3), 652-67. [CrossRef]
- 7. Luo, J., Liu, Y., Liu, Y., Wang, J., Chai, T., & Yuan, J., Chang, S., Yu, Y., Jing, S., Ma, H. (2017). Synthesis and theoretical studies of a new insensitive explosive, 2'-methyl-3-nitro-2'H- [1,3'-bi(1,2,4-triazole)]-5,5'-diamine. Central European Journal of Energetic Materials, 14(2), 269-280. [CrossRef]
- 8. Ahmed, S., Zayed, M., El-Messery, S., Al-Agamy, M., Abdel-Rahman, H. (2016). Design, Synthesis, Antimicrobial Evaluation and Molecular Modeling Study of 1,2,4-Triazole-Based 4- Thiazolidinones. Molecules, 21(5), 568. [CrossRef]
- 9. Ali, G., El-Hiti, G., Tomi, I., Haddad, R., Al-Qaisi, A., Yousif, E. (2016). Photostability and performance of polystyrene films containing 1,2,4-triazole-3-thiol ring system schiff bases. Molecules, 21(12), 1699. [CrossRef]
- 10. Sameliuk, Y. (2016). PhD Thesis. Synthesis and study of biologically active 1,2,4-triazoles-3- thione derivatives, which contain methoxyphenyl substituents. Zaporizhzhia State Medical University. [CrossRef]
- 11. Lin, G., Duan, W., Yang, L., Huang, M., Lei, F. (2017). Synthesis and antifungal activity of novel myrtenal-based 4-methyl-1,2,4-triazole-thioethers. Molecules, 22(2), 193. [CrossRef]
- 12. Benhammadi, S., Salimairaten, S., Othman, A. (2016). Synthetic studies and antibacterial activity of nucleobases and their N- and S-glucosidesfrom 2-amino benzoic acid and its benzamido derivatives.. Oriental Journal of Chemistry, 32(5), 2567-2576. [CrossRef]
- 13. Popiołek, Ł., Paruch, K., Patrejko, P., Biernasiuk, A., Wujec, M. (2016). New 3-hydroxy-2- naphthoic hydrazide derivatives: thiosemicarbazides and 1,2,4-triazole-3-thiones, their synthesis and in vitro antimicrobial evaluation. Journaltf the Iranian Chemical Society, 13(10), 1945-1951. [CrossRef]
- 14. Boraei, A., El Ashry, E., Duerkop, A. (2016). Regioselectivity of the alkylation of S-substituted 1,2,4-triazoles with dihaloalkanes. Chemistry Central Journal, 10, 22. [CrossRef]
- 15. Khalid, W., Badshah, A., Khan, A., Nadeem, H., Ahmed, S. (2018). Synthesis, characterization, molecular docking evaluation, antiplatelet and anticoagulant actions of 1,2,4 triazole hydrazone and sulphonamide novel derivatives. Chemistry Central Journal, 12, 11. [CrossRef]
- 16. Sargsyan, A., Avakyan, A., Vartanyan, S., Stepanyan, G., Paronikyan, R. (2018). Synthesis of new 1,4-benzodioxanуl-1,2,4-triazole derivatives. Russian Journal of General Chemistry, 88(4), 839-842. [CrossRef]
- 17. Idrees, M., Kola, S., Siddiqui, N. (2018). Synthesis of novel series of quinolino[3,2- f][1,2,4]triazolo[3,4-b][1,3,4]-thiadiazepines derivatives incorporated with 3-[5-(benzofuran-2- yl)-1-phenyl-1h-pyrazol-3-yl] moiety as potent antimicrobial agent. Asian Journal of Chemistry, 30(9), 2129-2133. [CrossRef]
- 18. Kumar, A., Naaz, A., Prakasham, A., Gangwar, M., Butcher, R., Panda, D., Ghosh, P. (2017). Potent anticancer activity with high selectivity of a chiral palladium n-heterocyclic carbene complex. ACS Omega, 2(8), 4632-4646. [CrossRef]
- 19. Li, J., Liu, H., Guo, Z., Yang, M., Song, J., Ma, H. (2018). Two Cu(ii)-triadimenol complexes as potential fungicides: synergistic actions and DFT calculations. RSC Advances, 8(6), 2933-2940. [CrossRef]
- 20. Van Dijk, B., Hofmann, J., Hetterscheid, D. (2018). Pinpointing the active species of the Cu(DAT) catalyzed oxygen reduction reaction. Physical Chemistry Chemical Physics, 20(29), 19625-19634. [CrossRef]
- 21. Wang, X., Bai, X., Lin, H., Sun, J., Wang, X., Liu, G. (2018). A series of new polyoxometalate- based metal–organic complexes with different rigid pyridyl-bis(triazole) ligands: assembly, structures and electrochemical properties. RSC Advances, 8(40), 22676-22686. [CrossRef]
- 22. Popov, I., Davis, B., Mukundan, R., Batista, E., Yang, P. (2019). Catalyst-inspired charge carriers for high energy density redox flow batteries. Frontiers In Physics, 6, 141. [CrossRef]
- 23. Arkhipushkin, I., Shikhaliev, K., Potapov, A., Sapronova, L., Kazansky, L. (2017). Inhibition of brass (80/20) by 5-mercaptopentyl-3-amino-1,2,4-triazole in neutral solutions. Metals, 7(11), 488. [CrossRef]
- 24. Del Bene, J., Elguero, J., Alkorta, I. (2018). Complexes of CO2 with the azoles: tetrel bonds, hydrogen bonds and other secondary interactions. Molecules, 23(4), 906. [CrossRef]
- 25. Bagihalli, G., Patil, S., Badami, P. (2009). Synthesis, spectral characterization, in vitro microbial and cytotoxic studies of lanthanum(III) and thorium(IV) complexes with 1,2,4-triazole Schiff bases. Journal of Enzyme Inhibition And Medicinal Chemistry, 24(3), 730-741. [CrossRef]
- 26. Chen, D., Zheng, Y., Shi, D., Fang, S. (2020). An acid-base resistant polyoxometalate-based metal–organic framework constructed from {Cu4Cl}7+ and {Cu2(CO2)4} clusters for photocatalytic degradation of organic dye. Journal of Solid State Chemistry, 287, 121384. [CrossRef]
- 27. Hulina, Y., Kaplaushenko, A. (2017). Synthesis and physical-chemical properties of 6-(5-(1Н- tetrazole-1-ylmethyl)-4-R-1,2,4-triazole-3-ylthio)pyridin-3-amines and 6-((5-(1Н-tetrazole-1- yl)methil-4-R-1,2,4-triazole-3-ylthio)pyridin-3-yl)-(alk,ar,heter)ylmethanimines. Zaporozhye Medical Journal, 19(1), 100-104. [CrossRef]
- 28. Frolova, Y. (2020). Design, synthesis, antimicrobial and antifungal activities of new 1,2,4-triazole derivatives containing 1H-tetrazole moiety. Journal of Faculty of Pharmacy of Ankara University, , 44(1), 70-88. [CrossRef]
- 29. Shcherbyna, R. (2019). Microwave-assisted synthesis of some new derivatives of 4-substituted- 3-(morpholinomethyl)-4H-1,2,4-triazole-5-thioles. Journal of Faculty of Pharmacy of Ankara University, , 43(3), 220-229. [CrossRef]
- 30. Shcherbyna, R., Parchenko, V., Varynskyi, B., Kaplaushenko, A. (2019). The development of HPLC-DAD method for determination of active pharmaceutical ingredient in the potassium 2- ((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazol-3-yl)thio)acetate substance. Current Issues In Pharmacy And Medical Sciences, 32(1), 5-9. [CrossRef]
- 31. Varynskyi, B., Kaplaushenko, A. (2019). The Force degradation study of the morpholinium 2- ((4-(2-methoxyphenyl)-5-(pyridin-4-yl)-4h-1,2,4-triazol-3-yl)thio)acetate. Indonesian Journal of Pharmacy, 30(1), 25-34. [CrossRef]
- 32. Danilchenko, D., Safonov, А. (2017). Diuretic activity of 2-((4-amino-5-R-4H-1,2,4-triazole-3- yl)thio)acetohydrazides. Zaporozhye Medical Journal, 19(4), 517-519. [CrossRef]
- 33. Vashchyk, Y., Shcherbyna, R., Parchenko, V., Bushueva, I., Gutyj, B., Fotina, H., Stronskyi, Y. (2020). Histological study of a corrective influence of a compound potassium 2-((4-amino-5- (morpholinomethyl)-4H-1,2,4-triazol-3-yl) thio)acetate (pkr-173) on the state of chicken's liver under infection by pseudomonas aeruginosa. Journal of Faculty of Pharmacy of Ankara University, 44(1), 1-17. [CrossRef]
- 34. Shcherbyna R. (2020). An investigation of the pharmacokinetics and potential metabolites of potassium 2-((4-amino-5-(morfolinometyl)-4H-1,2,4-triazol-3-yl)thio) acetate on rats. Journal of Faculty of Pharmacy of Ankara University , 44(2), 233-241. [CrossRef]
- 35. Safonov, A. A., & Nevmyvaka, A. V. (2020). Actoprotective activity research of 2-((5-(2- bromophenyl)-4-substituted-4H-1,2,4-triazole-3-yl)thio)acetates. . Current issues in pharmacy and medicine: science and practice, 13(2), 260-264. [CrossRef]
- 36. Ihnatova, T., Kaplaushenko, A., Frolova, Y., Pryhlo, E. (2021). Synthesis and antioxidant properties of some new 5-phenethyl-3-thio-1, 2, 4-triazoles. Pharmacia, 68, 129-133. [CrossRef]
- 37. Gotsulya, A., Zazhzharskiy, V., Davidenko, P. (2020). Features of experimental modeling of tuberculosis in guinea pig with the participation of N'-(2-(5-((thephylline-7-yl)methyl)-4-R-1,2,4- triazole- ylthio)acethyl)isonicotinohydrazide. Ukrainian Journal of Ecology, 10(4), 191-194. [CrossRef]
- 38. Hotsulia, A.S., Fedotov, S.O. (2020). Synthesis and properties of 2-(4-phenyl-5-(((5- phenylamino-1,3,4-thiadiazole-2-yl)thio)methyl)-1,2,4-triazole-3-yl)thio)ethanoic acid and its salts. Current issues in pharmacy and medicine: science and practice, 3, 330-336. [CrossRef]
- 39. Zozulynets, D.М., Kaplaushenko, A.G., Korzhova, A.S. (2021). The synthesis of 4-amino-5- (quinolin-2-yl)-4H-1,2,4-triazole-3-thiol and its interaction with aldehydes. Journal of Organic and Pharmaceutical Chemistry, 19(1(73)), 48-52. [CrossRef]
- 40. Varynskyi, B., Kaplaushenko, A. (2020). Metabolism study of morpholinium 2-((4-(2- methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-yl)thio)acetate. Current Issues in Pharmacy and Medical Sciences, 33(2), 72-75. [CrossRef]