SİKLOOKSİJENAZ İNHİBİTÖRLERİ OLARAK BAZI 4,5-DİHİDRO-1H-PİRAZOL TÜREVLERİ ÜZERİNDE MOLEKÜLER DOKİNG ÇALIŞMALARI

Amaç: Antiinflamatuvar etkileri olduğu düşünülen bazı 4,5-dihidro-1H-pirazol türevlerinin siklooksijenaz 1(COX-1) ve siklooksijenaz 2 (COX-2) enzimleri ile etkileşimlerini incelemek amacıyla bu enzimler üzerinde docking çalışmaları yapılmıştır.

Anahtar Kelimeler:

Siklooksijenaz 1, siklooksijenaz 2, 4, 5-dihidro-1H-pirazol, inflamasyon, moleküler doking, 4, 5-dihidro-1H-pirazol

MOLECULAR DOCKING STUDIES ON SOME 4,5-DIHYDRO-1H-PYRAZOLE DERIVATIVES AS CYCLOOXYGENASE INHIBITORS

Objective: To examine the interactions of some 4,5-dihydro-1H-pyrazole derivatives, which are thought to have antiinflammatory effects, with cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes, docking studies were carried out on these enzymes.

Keywords:

Cyclooxygenase-1, cyclooxygenase-2, 4, 5-dihydro-1H-pyrazole, inflammation, molecular docking, 4, 5-dihydro-1H-pyrazole,

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