YENİ İZOLE EDILEN VB_K1 BAKTERİYOFAJININ İZOLASYONU VE ESBL POZİTİF KLEBSİELLA TÜRLERİ ÜZERİNE DUYARLILIĞININ ARAŞTIRILMASI

Amaç: Klebsiella ile ilişkili enfeksiyonların tedavisinde kullanılan antimikrobiyallerin etkinliğindeki azalma, alternatif tedavi strateji arayışlarını gerektirmiştir. Bu çalışma Klebsiella türlerine özgü litik karakterde bakteriyofaj izolasyonunun sağlanmasını ve alternatif antimikrobiyal ajan olarak kullanım potansiyelinin araştırılmasını amaçlamaktadır.

ISOLATION OF NEWLY ISOLATED VB_K1 BACTERIOPHAGE AND INVESTIGATION OF SUSCEPTIBILITY ON ESBL POSITIVE KLEBSIELLA SPP. STRAINS

Objective: The decrease in the efficacy of antimicrobials in the treatment of Klebsiella-related infections necessitated the search for alternative treatment strategies. This study aims to provide isolation of lytic bacteriophage specific to Klebsiella species and to investigate its potential for use as alternative antimicrobial agent.

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  • 1. Podschun, R., Ullmann, U. (1998). Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clinical Microbiology Reviews, 11(4), 589- 603. [CrossRef]
  • 2. Moxon, C. A., Paulus, S. (2016). Beta-lactamases in Enterobacteriaceae infections in children. Journal of Infection, 72 Suppl, S41-49. [CrossRef]
  • 3. Bitsori, M., Galanakis, E. (2019). Treatment of urinary tract infections caused by ESBL- producing Escherichia coli or Klebsiella pneumoniae. The Pediatric Infectious Disease Journal, 38(12), e332-e335. [CrossRef]
  • 4. Peleg, A. Y., Hooper, D. C. (2010). Hospital-acquired infections due to gram-negative bacteria. New England Journal of Medicine, 362(19), 1804-1813. [CrossRef]
  • 5. Golkar, Z., Bagasra, O., Pace, D. G. (2014). Bacteriophage therapy: a potential solution for the antibiotic resistance crisis. The Journal of Infection in Developing Countries, 8(2), 129-136. [CrossRef]
  • 6. Chanishvili, N. (2012). A literature review of the practical application of bacteriophage research. New York: Nova Biomedical Books.
  • 7. Bruttin, A., Brüssow, H. (2005). Human volunteers receiving Escherichia coli phage T4 orally: a safety test of phage therapy. Antimicrobial Agents and Chemotherapy, 49(7), 2874-2878. [CrossRef]
  • 8. Domingo-Calap, P., Delgado-Martinez, J. (2018). Bacteriophages: protagonists of a post- antibiotic era. Antibiotics (Basel), 7(3), 1-16. [CrossRef]
  • 9. Kazi, M., Annapure, U. S. (2016). Bacteriophage biocontrol of foodborne pathogens. Journal of Food Science and Technology, 53(3), 1355-1362. [CrossRef]
  • 10. Guttman, B., Raya, R., Kutter, E. (2005). Basic phage biology. Bacteriophages: Biology and applications, 4.
  • 11. Harper, D. R., Parracho, H. M. R. T., Walker, J., Sharp, R., Hughes, G., Werthén, M., Morales, S. (2014). Bacteriophages and biofilms. Antibiotics, 3(3), 270-284. [CrossRef]
  • 12. Kochetkova, V. A., Mamontov, A. S., Moskovtseva, R. L., Erastova, E. I., Trofimov, E. I., Popov, M. I., Dzhubalieva, S. K. (1989). Phagotherapy of postoperative suppurative-inflammatory complications in patients with neoplasms. Sovetskaia Meditsina, (6), 23-26.
  • 13. Domingo-Calap, P., Beamud, B., Mora-Quilis, L., González-Candelas, F., Sanjuán, R. (2020). Isolation and characterization of two Klebsiella pneumoniae phages encoding divergent depolymerases. International Journal of Molecular Sciences, 21(9), 3160. [CrossRef]
  • 14. Karamoddini, M. K., Fazli-Bazzaz, B. S., Emamipour, F., Ghannad, M. S., Jahanshahi, A. R., Saed, N., & Sahebkar, A. (2011a). Antibacterial efficacy of lytic bacteriophages against antibiotic-resistant Klebsiella species. The Scientific World Journal, 11, 370161. [CrossRef]
  • 15. Kumari, S., Harjai, K., Chhibber, S. (2011). Bacteriophage versus antimicrobial agents for the treatment of murine burn wound infection caused by Klebsiella pneumoniae B5055. Journal of Medical Microbiology, 60(Pt 2), 205-210. [CrossRef]
  • 16. Wintachai, P., Naknaen, A., Thammaphet, J., Pomwised, R., Phaonakrop, N., Roytrakul, S., Smith, D. R. (2020). Characterization of extended-spectrum-β-lactamase producing Klebsiella pneumoniae phage KP1801 and evaluation of therapeutic efficacy in vitro and in vivo. Scientific Reports, 10(1), 11803. [CrossRef]
  • 17. Adams, M. H. (1959). Bacteriophages: Interscience publishers.
  • 18. Merabishvili, M., Pirnay, J.-P., Verbeken, G., Chanishvili, N., Tediashvili, M., Lashkhi, N., Vaneechoutte, M. (2009). Quality-controlled small-scale production of a well-defined bacteriophage cocktail for use in human clinical trials. PLoS One, 4(3), e4944-e4944. [CrossRef]
  • 19. Oliveira, H., Pinto, G., Oliveira, A., Oliveira, C., Faustino, M. A., Briers, Y., Azeredo, J. (2016). Characterization and genome sequencing of a Citrobacter freundii phage CfP1 harboring a lysin active against multidrug-resistant isolates. Applied Microbiology and Biotechnology, 100(24), 10543-10553. [CrossRef]
  • 20. Sambrook, J., Fritsch, E. F., Maniatis, T. (1989). Molecular cloning: a laboratory manual: Cold spring harbor laboratory press.
  • 21. Sasikala, D., Srinivasan, P. (2016). Characterization of potential lytic bacteriophage against Vibrio alginolyticus and its therapeutic implications on biofilm dispersal. Microbial Pathogenesis, 101, 24-35. [CrossRef]
  • 22. Knezevic, P., Kostanjsek, R., Obreht, D., Petrovic, O. (2009). Isolation of Pseudomonas aeruginosa specific phages with broad activity spectra. Current Microbiology, 59(2), 173. [CrossRef]
  • 23. Herridge, W. P., Shibu, P., O'Shea, J., Brook, T. C., Hoyles, L. (2020). Bacteriophages of Klebsiella spp., their diversity and potential therapeutic uses. Journal of Medical Microbiology, 69(2), 176-194. [CrossRef]
  • 24. Harper, D. R. (2018). Criteria for selecting suitable infectious diseases for phage therapy. Viruses, 10(4), 177. [CrossRef]
  • 25. Townsend, E. M., Kelly, L., Gannon, L., Muscatt, G., Dunstan, R., Michniewski, S., Jameson, E. (2021). Isolation and characterization of Klebsiella phages for phage therapy. Phage (New Rochelle), 2(1), 26-42. [CrossRef]
  • 26. Karumidze, N., Kusradze, I., Rigvava, S., Goderdzishvili, M., Rajakumar, K., Alavidze, Z. (2013). Isolation and characterisation of lytic bacteriophages of Klebsiella pneumoniae and Klebsiella oxytoca. Current Microbiology, 66(3), 251-258. [CrossRef]
  • 27. Karamoddini, M. K., Fazli-Bazzaz, B. S., Emamipour, F., Ghannad, M. S., Jahanshahi, A. R., Saed, N., Sahebkar, A. (2011b). Antibacterial efficacy of lytic bacteriophages against antibiotic- resistant Klebsiella species. The Scientific World Journal, 11, 1332-1340. [CrossRef]
  • 28. Drulis-Kawa, Z., Mackiewicz, P., Kęsik-Szeloch, A., Maciaszczyk-Dziubinska, E., Weber- Dąbrowska, B., Dorotkiewicz-Jach, A., Kropinski, A. M. (2011). Isolation and characterisation of KP34—a novel φKMV-like bacteriophage for Klebsiella pneumoniae. Applied Microbiology and Biotechnology, 90(4), 1333-1345. [CrossRef]
Ankara Üniversitesi Eczacılık Fakültesi Dergisi-Cover
  • ISSN: 1015-3918
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 2016
  • Yayıncı: Ankara Üniversitesi Eczacılık Fakültesi
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