GALIUM APARINE’NİN ANTİOKSİDAN, ANTİMİKROBİYAL VE ANTİPROLİFERATİF AKTİVİTELERİ

Amaç: Bitkilerin birçok biyolojik aktiviteye sahip olduğu bilinmektedir. Bu çalışmada Galium aparine L.'nin antioksidan, oksidan, antimikrobiyal ve antiproliferatif aktiviteleri araştırıldı.

ANTIOXIDANT, ANTIMICROBIAL AND ANTIPROLIFERATIVE ACTIVITIES OF GALIUM APARINE

Objective: Plants are known to have many biological activities. In this study, the antioxidant, oxidant, antimicrobial and antiproliferative activities of Galium aparine L. were investigated.

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  • 1. Merken, H.M., Beecher, G.R. (2000). Measurement of food flavonoids by high-performance liquid chromatography: a review. Journal of Agricultural and Food Chemistry, 48(3), 577-599. [CrossRef]
  • 2. de Souza, L.M., Cipriani, T.R., Iacomini, M., Gorin, P. A., Sassaki, G.L. (2008). HPLC/ESI-MS and NMR analysis of flavonoids and tannins in bioactive extract from leaves of Maytenus ilicifolia. Journal of Pharmaceutical and Biomedical Analysis, 47(1), 59-67. [CrossRef]
  • 3. CABI, 2018. Invasive Species Compendium. [WWW Document]. URL https://www.cabi. org/isc/datasheet/24772 (Accessed 2 February 18).
  • 4. Malik, N., Born, W.V. (1988). The biology of Canadian weeds.: 86. Galium aparine L. and Galium spurium L. Canadian Journal of Plant Science, 68(2), 481-499. [CrossRef]
  • 5. Tobyn, G., Denham, A., Whitelegg, M. (2016). The Western herbal tradition: 2000 years of medicinal plant knowledge. Singing Dragon.
  • 6. Bokhari, J., Khan, M.R., Shabbir, M., Rashid, U., Jan, S., Zai, J. A. (2013). Evaluation of diverse antioxidant activities of Galium aparine. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 102, 24-29. [CrossRef]
  • 7. Deliorman, D., Calis, I., Ergun, F. (2001). Iridoids from Galium aparine. Pharmaceutical Biology, 39(3), 234-235.
  • 8. Aslantürk, Ö.S., Çelik, T.A., Karabey, B., Karabey, F. (2017). Active Phytochemical Detecting, Antioxidant, Cytotoxic, Apoptotic Activities of Ethyl Acetate and Methanol Extracts of Galium aparine L. Journal of Pharmaceutical Research International, 1-16. [CrossRef]
  • 9. Goryacha, O.V., Ilyina, T.V., Kovalyova, A.M., Kashpur, N. V. (2014). Phytochemical research of Galium aparine L. lipophilic complex and study of its antibacterial activity.
  • 10. Vlase, L., Mocan, A., Hanganu, D., Benedec, D., Gheldiu, A., Crisan, G. (2014). Comparative study of polyphenolic content, antioxidant and antimicrobial activity of four Galium species (Rubiaceae). Digest Journal of Nanomaterials and Biostructures, 9(3), 1085-1094.
  • 11. Moubasher, H., Abd El-Ghani, M., Al-Wakeel, S., Bahoor, A. (2016). Chemotaxonomic significance of flavonoids in some species of Galium (Rubiaceae) from Libya. Austin Journal of Plant Biology, 2(1), 1014.
  • 12. Mocan, A., Crisan, G., Vlase, L., Ivanescu, B., Badarau, A.S., Arsene, A.L. (2016). Phytochemical investigations on four Galium species (Rubiaceae) from Romania. Farmacia, 64(1), 95-99.
  • 13. Ahmad, S.S., Javed, S.U.M.A.I.R.A. (2007). Exploring the economic value of underutilized plant species in Ayubia National Park. Pakistan Journal of Botany, 39(5), 1435-1442.
  • 14. Taskin, T., Bitis, L. (2016). In vitro antioxidant activity of eight wild edible plants in Bursa province of Turkey. Medicine, 6, 25.
  • 15. Shirwaikar, A., Shirwaikar, A., Rajendran, K., Punitha, I.S.R. (2006). In vitro antioxidant studies on the benzyl tetra isoquinoline alkaloid berberine. Biological and Pharmaceutical Bulletin, 29(9), 1906-1910. [CrossRef]
  • 16. Soni, H., Pandey, H., Phatak, A. K., Nayak, G., Singhai, A. K., Parihar, A., Singh, V., Rathur, A. S. (2009). Evaluation of antioxidant potential of hydro alcoholic extract of leaves of Coleus aromaticus. Advances in Pharmacology and Toxicology, 10(1), 75-82.
  • 17. Jain, S., Gupta, A., Malviya, N., Suhur, H. (2009). Comparative antioxidant potential screening of polyherbal formulations. Advances in Pharmacology and Toxicology, 10(1), 101-110.
  • 18. Erel, O. (2004). A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clinical Biochemistry, 37(4), 277-285. [CrossRef]
  • 19. Erel, O. (2005). A new automated colorimetric method for measuring total oxidant status. Clinical Biochemistry, 38(12), 1103-1111. [CrossRef]
  • 20. Sevindik, M. (2019). The novel biological tests on various extracts of Cerioporus varius. Fresenius Environmental Bulletin, 28(5), 3713-3717.
  • 21. Bauer, A.W. (1966). Antibiotic susceptibility testing by a standardized single disc method. American Journal of Clinical Pathology, 45, 149-158.
  • 22. Hindler, J., Hochstein, L., Howell, A. (1992). Preparation of routine media and reagents used in antimicrobial susceptibility testing. Part 1. McFarland standards, p. 5.19.1-5.19.6. In H. D. Isenberg (ed) Clinical microbiology procedures handbook, vol. 1. American Society for Microbiology, Washington, D.C.
  • 23. CLSI (Clinical and Laboratory Standards Institute). (2012). Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically, Approved Standard, 9th ed., CLSI document M07-A9. Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA.
  • 24. Matuschek, E., Brown, D.F., Kahlmeter, G. (2014). Development of the EUCAST disk diffusion antimicrobial susceptibility testing method and its implementation in routine microbiology laboratories. Clinical Microbiology and Infection 20: 255-266. [CrossRef]
  • 25. EUCAST (European Committee on Antimicrobial Susceptibility Testing). (2014). Breakpoint tables Fungal isolate for interpretation of MICs. Version 7.0.
  • 26. EUCAST (European Committee on Antimicrobial Susceptibility Testing). (2015). Breakpoint tables for Bacteria interpretation of MICs and zone diameters, Version 5.0.
  • 27. Bal, C., Akgul, H., Sevindik, M., Akata, I., Yumrutas, O. (2017). Determination of the anti- oxidative activities of six mushrooms. Fresenius Environmental Bulletin, 26(10), 6246-6252.
  • 28. Eberhardt, M.V., Lee, C.Y., Liu, R.H. (2000). Antioxidant activity of fresh apples. Nature, 405(6789), 903-904. [CrossRef]
  • 29. Zhao, R., Chen, Z., Jia, G., Li, J., Cai, Y., Shao, X. (2011). Protective effects of diosmetin extracted from Galium verum L. on the thymus of U14-bearing mice. Canadian Journal of Physiology and Pharmacology, 89(9), 665-673. [CrossRef]
  • 30. Sevindik, M. (2020). Antioxidant and antimicrobial capacity of Lactifluus rugatus and its antiproliferative activity on A549 cells. Indian Journal of Traditional Knowledge (IJTK), 19(2), 423-427.
  • 31. Mohammed, F.S., Akgul, H., Sevindik, M., Khaled, B.M.T. (2018). Phenolic content and biological activities of Rhus coriaria var. zebaria. Fresenius Environmental Bulletin, 27(8), 5694- 5702.
  • 32. Sevindik, M., Akgul, H., Pehlivan, M., Selamoglu, Z. (2017). Determination of therapeutic potential of Mentha longifolia ssp. longifolia. Fresenius Environmental Bulletin, 26(7), 4757- 4763.
  • 33. Verma, P.K., Raina, R., Sultana, M., Singh, M., Kumar, P. (2016). Total antioxidant and oxidant status of plasma and renal tissue of cisplatin-induced nephrotoxic rats: protection by floral extracts of Calendula officinalis Linn. Renal Failure, 38(1), 142-150. [CrossRef]
  • 34. Mohammed, F.S., Karakaş, M., Akgül, H., Sevindik, M. (2019). Medicinal properties of Allium calocephalum collected from Gara Mountain (Iraq). Fresenius Environmental Bulletin, 28(10), 7419-7426.
  • 35. Mohammed, F.S., Günal, S., Şabik, A.E., Akgül, H., Sevindik, M. (2020). Antioxidant and Antimicrobial activity of Scorzonera papposa collected from Iraq and Turkey. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 23(5), 1114-1118. [CrossRef]
  • 36. Mohammed, F.S., Günal, S., Pehlivan, M., Doğan, M., Sevindik, M., Akgül, H. (2020). Phenolic content, antioxidant and antimicrobial potential of endemic Ferulago platycarpa. Gazi University Journal of Science, 33(4), 670-677. [CrossRef]
  • 37. Mohammed, F.S., Şabik, A.E., Sevindik, E., Pehlivan, M., Sevindik, M. (2020). Determination of Antioxidant and Oxidant Potentials of Thymbra spicata Collected from Duhok-Iraq. Turkish Journal of Agriculture-Food Science and Technology, 8(5), 1171-1173. [CrossRef]
  • 38. Saraç, H., Demirbaş, A., Daştan, S.D., Ataş, M., Çevik, Ö., Eruygur, N. (2019). Evaluation of Nutrients and Biological Activities of Kenger (Gundellia tournefortii L.) Seeds Cultivated in Sivas Province. Turkish Journal of Agriculture-Food Science and Technology, 7(sp2), 52-58. [CrossRef]
  • 39. Daştan, S.D., Durukan, H., Demirbaş, A., Dönmez, E. (2019). Bioactivity and Therapeutic Properties of Evelik (Rumex crispus), A Naturally Growing and Edible Plant in Sivas Province. Turkish Journal of Agriculture-Food Science and Technology, 7(sp2), 67-71. [CrossRef]
  • 40. Senio, S., Pereira, C., Vaz, J., Sokovic, M., Barros, L., Ferreira, I.C. (2018). Dehydration process influences the phenolic profile, antioxidant and antimicrobial properties of Galium aparine L. Industrial Crops and Products, 120, 97-103. [CrossRef]
  • 41. Ilyina, T.V., Goryacha, O.V., Toryanik, E. L., Kulish, I.A., Kovaleva, A.M. (2016). Antimicrobial Activity of the Genus Galium L.
  • 42. Bolivar, P., Cruz-Paredes, C., Hernández, L. R., Juárez, Z.N., Sánchez-Arreola, E., Av-Gay, Y., Bach, H. (2011). Antimicrobial, anti-inflammatory, antiparasitic, and cytotoxic activities of Galium mexicanum. Journal of Ethnopharmacology, 137(1), 141-147. [CrossRef]
  • 43. Atmaca, H., Bozkurt, E., Cittan, M., Tepe, H.D. (2016). Effects of Galium aparine extract on the cell viability, cell cycle and cell death in breast cancer cell lines. Journal of Ethnopharmacology, 186, 305-310. [CrossRef]