AKUT HAREKETSİZLİK STRES KOŞULLARINDA SODYUM 2-((4-AMİNO-5-(TİYOFEN-2-İLMETİL)-4H-1,2,4-TRİAZOL-3-İL)TİYO) ASETAT’IN SIÇAN KARACİĞERİNİN DURUMU ÜZERİNDEKİ DÜZELTİCİ ETKİSİNİN HİSTOLOJİK ÇALIŞMASI

Amaç: Çalışmanın amacı, akut immobilizasyon stresi koşulları altında sodyum 2-((4-amino-5-(tiofen-2-ilmetil)-4H-1,2,4-triazol-3-il) tio) asetat’ın sıçan karaciğeri üzerindeki düzeltici etkisinin histolojik açıdan çalışılmasıydı.

HISTOLOGICAL STUDY OF A CORRECTIVE INFLUENCE OF SODIUM 2-((4-AMINO-5-(THIOPHEN-2-YLMETHYL)-4H-1,2,4-TRIAZOL-3-YL)THIO) ACETATE ON THE STATE OF RATS LIVER UNDER CONDITIONS OF ACUTE IMMOBILIZATION STRESS

Objective: The aim of the work was the histological study of a corrective influence of sodium 2-((4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl) thio) acetate on the state of rats liver under conditions of acute immobilization stress.

___

  • Sahakyan, N.A., Shogeryan, S.A., Simonyan, L.Y., Avanesyan, L.G. (2017). The effect of taurine on heart rate variability and structural and functional changes in the liver and adrenal glands during immobilization stress. Biological Journal of Armenia, 69 (1), 61-67. [http://test.journals.sci.am/index.php/sci-armenian-biology/article/view/1342]
  • Lomakina, Yu.V., Bulyk, R.E., Chernovskaya, N.V. (2015). Stress-limiting system of an aging organism under immobilization stress. Priority directions of development of science and education, (2), 14-15. [https://interactive-plus.ru/e-articles/138/Action138-9894.pdf]
  • Prokudina, E.S., Gorbunov, A.S., Kazakov, V.A., Saushkin, V.V., Maslov, L.N. (2019). Morphofunctional aspects of heart damage during immobilization stress in rats. Russian physiological journal. IM Sechenov, 105 (2), 248-257. [https://doi.org/10.1134/S0869813919020110]
  • Sameliuk, Y., Kaplaushenko, T., Al Zedan, F. (2021). 1,2,4-Triazole derivatives in medicine and pharmacy and application prospects. Journal of Faculty of Pharmacy of Ankara University, 45(3), 598-614. [Doi: 10.33483/jfpau.885888]
  • Shcherbyna, R. (2019). Microwave-assisted synthesis of some new derivatives of 4-substituted-3-(morpholinomethyl)-4H-1,2,4-triazole-5-thioles. Journal of Faculty of Pharmacy of Ankara University, 43 (3) , 220-229 . [DOI: 10.33483/jfpau.533166]
  • Safonov, A. (2020). Microwave synthesis of new N-R-3-(alkylthio)-5-(thiophen-2-ylmethyl)-1,2,4-triazol-4-amines. Journal of Faculty of Pharmacy of Ankara University, 44 (1), 89-98. [DOI: 10.33483/jfpau.620599]
  • Shcherbyna, R.A., Panasenko, A.I., Knysh, E.G., Varinsky, B.A. (2014). Synthesis and physicochemical properties of 2-((4-R-3-(morpholinomethylene)-4H-1,2,4-triazol-5-yl)thio)acetic acids. Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 3 (16), 18-21. [https://doi.org/10.14739/2409-2932.2014.3.30016]
  • Hulina, Y. S., Kaplaushenko, A. G. (2018). Synthesis, physical and chemical properties of 5-((1H-tetrazole-1-yl) methyl)-4-R-4H-1, 2, 4-triazole-3-thiols and their chemical transformations. Biopharmaceutical Journal, 10 (1), 26-30. [https://elibrary.ru/item.asp?id=32694739]
  • Shcherbyna, R., Parchenko, V., Varynskyi, B., Kaplaushenko, A. (2019). The development of HPLC-DAD method for determination of active pharmaceutical ingredient in the potassium 2-((4-amino-5-(morpholinomethyl)-4H-1, 2, 4-triazol-3-yl) thio) acetate substance. Current Issues in Pharmacy and Medical Sciences, 32(1), 5-9. [doi:10.2478/cipms-2019-0001]
  • Frolova, Y., Kaplaushenko, A., Nagornaya, N. (2020). Design, synthesis, antimicrobial and antifungal activities of new 1,2,4-triazole derivatives containing 1H-tetrazole moiety. Journal of Faculty of Pharmacy of Ankara University, 44 (1), 70-88. [DOI: 10.33483/jfpau.574001]
  • Shcherbyna, R. (2020). An investigation of the pharmacokinetics and potential metabolites of potassium 2-((4-amino-5-(morfolinometyl)-4H-1,2,4-triazol-3-yl)thio)acetate on rats. Journal of Faculty of Pharmacy of Ankara University, 44 (2), 233-241. [DOI: 10.33483/jfpau.681611]
  • Shcherbyna, R., Vashchyk, Y. (2019). The research of 1,2,4-triazole derivatives hepatoprotective activity under tetracycline and infectious hepatitis. Journal of Faculty of Pharmacy of Ankara University, 43 (2), 135-146. [DOI: 10.33483/jfpau.487173]
  • Vashchyk, Y., Shcherbyna, R., Parchenko, V., Bushueva, İ., Gutyj, B., Fotına, H., Fotına, T., Stronskyı, Y. (2020). Histological study of a corrective influence of a compound potassium 2-((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazol-3-yl)thio)acetate (PKR-173) on the state of chicken's liver under infection by pseudomonas aeruginosa. Journal of Faculty of Pharmacy of Ankara University, 44 (1), 1-17 . [DOI: 10.33483/jfpau.567757]
  • Shcherbyna, R., Parchenko, V., Martynyshyn, V., Hunchak, V.. (2018). Evaluation of acute and subacute toxicity of oil liniment based on 4-((5-(decylthio)-4-methyl-4H-1,2,4-triazol-3-yl)methyl)morpholine. Journal of Faculty of Pharmacy of Ankara University, 42 (1), 43-52. [https://dergipark.org.tr/en/pub/jfpanu/issue/42653/514314]
  • Samelyuk, Y. G., Kaplaushenko, A. G. (2014). Synthesis of 3-alkylthio (sulfo)-1,2,4-triazoles, containing methoxyphenyl substituents at C5atoms, their antipyretic activity, propensity to adsorption and acute toxicity. Journal of Chemical and Pharmaceutical Research, 6(5), 1117-1121. [https://www.jocpr.com/articles/synthesis-of-3alkylthiosulfo124triazoles-containing-methoxyphenyl-substituents-at-c5-atoms-their-antipyretic-activity-pr.pdf]
  • Knysh Y.G., Panasenko O.I., Safonov A.A. (2016). Sodium 2-((4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl)thio)acetate, which shows actoprotective activity. Patent of Ukraine № 112619, Patent published on 26.09.2016, bulletin. № 18/2016. [https://base.uipv.org/searchINV/search.php?action=viewdetails&IdClaim=227417]
  • Vyborova, I.S., Khandzhav, U., Vasilieva, L.S., Makarova, N.G. (2005). The structure of the liver in rats in the dynamics of immobilization stress. Siberian Medical Journal (Irkutsk), 52 (3), 30-33. [https://cyberleninka.ru/article/n/struktura-pecheni-u-krys-v-dinamike-immobilizatsionnogo-stressa]
  • Nair, A. B., & Jacob, S. (2016). A simple practice guide for dose conversion between animals and human. Journal of basic and clinical pharmacy, 7(2), 27. [doi:10.4103/0976-0105.177703]
  • National research council. (2011). Guide for the care and use of laboratory animals: eighth edition, Washington, DC: The National Academies Press, p. 246. [https://doi.org/10.17226/12910]
  • Union, E. (2010). Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes. Official Journal of the European Union, 276, 33-79. [https://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2010:276:0033:0079:en:PDF]
  • Mironov, A. K. (2012). Guidelines for conducting preclinical studies of drugs. Part one, M. Grif i K, p 944.
  • Ivanov, A.V., Bobyntsev, I.I., Shepeleva, O.M., Kryukov, A.A., Andreeva, L.A., Myasoedov, N.F. (2017). Morphological changes in the liver of rats under stress and their features after the introduction of Semax. Morphology, 151 (1), 39-43. [ftp://fulltext.kursksmu.net/fulltext/Publications_KGMU/2017/morfologicheskie.pdf]
Ankara Üniversitesi Eczacılık Fakültesi Dergisi-Cover
  • ISSN: 1015-3918
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 2016
  • Yayıncı: Ankara Üniversitesi Eczacılık Fakültesi