3- VE 4-SÜBSTİTÜE-5-((3-FENİLPROPİL)TİYO)-4H-1,2,4-TRİAZOLLERİN MİKRODALGA SENTEZİ
Amaç: Bu çalışmanın amacı, Milestone Flexi Wave mikrodalga sentez sistemi ile 3- ve 4-sübstitüe-5-((3-fenilpropil)tiyo)-4H-1,2,4-triazolleri sentezlemek ve sentez için en iyi yöntemi belirlemektir.
MICROWAVE SYNTHESIS OF 3- AND 4-SUBSTITUTED-5-((3-PHENYLPROPYL)THIO)-4H-1,2,4-TRIAZOLES
Objective: The purpose of this work was to synthesize 3- and 4-substituted-5-((3-phenylpropyl)thio) 4H-1,2,4-triazoles by the Milestone Flexi Wave microwave synthesis system and choose the best method of synthesis.
___
- 1. Frolova, Y., Kaplaushenko, A., Nagornaya, N. (2020). Design, synthesis, antimicrobial and antifungal activities of new 1,2,4-triazole derivatives containing 1H-tetrazole moiety. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, 44(1), 70-88. [CrossRef]
- 2. Shcherbyna, R. (2020). An investigation of the pharmacokinetics and potential metabolites of potassium 2-((4-amino-5-(morfolinometyl)-4H-1,2,4-triazol-3-yl)thio)acetate on rats. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, 44(2), 233-241. [CrossRef]
- 3. Shcherbyna, R., Vashchyk, Y. (2019). The research of 1,2,4-triazole derivatives hepatoprotective activity under tetracycline and infectious hepatitis. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, 43(2), 135-146. [CrossRef]
- 4. Vashchyk, Y., Shcherbyna, R., Parchenko, V., Bushueva, I., Gutyj, B., Fotina, H., Stronskyi, Y. (2020). Histological study of a corrective influence of a compound potassium 2-((4-amino-5- (morpholinomethyl)-4H-1, 2, 4-triazol-3-yl) thio) acetate (pkr-173) on the state of chicken's liver under infection by pseudomonas aeruginosa. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, 44(1), 1-17. [CrossRef]
- 5. Shcherbyna, R., Parchenko, V., Martynyshyn, V., Hunchak, V. (2018). Evaluation of acute and subacute toxicity of oil liniment based on 4-((5-(decylthio)-4-methyl-4H-1,2,4-triazol-3- yl)methyl)morpholine. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, 42(1), 43-52. [CrossRef]
- 6. Rud, A.M., Kaplaushenko, A.G., Pruglo, Y.S., Frolova, Y.S. (2018). Establishment of diuretic activity indicators for (3-thio-4-R-4-H-1,2,4-triazole-5-yl)(phenyl)methanols and their derivatives. Current Issues in Pharmacy and Medicine: Science and Practice, 2, 215-219. [CrossRef]
- 7. Hulina, Y.S., Kaplaushenko, A.G. (2018). Synthesis, physicochemical properties and further transformations in the series 5-((1H-tetrazol-1-yl)methyl)-4-R-4H-1,2,4-triazol-3-thiols and their chemical transformations. Russian Journal of Biopharmaceuticals, 10(1), 26-30, from https://submit.biopharmj.ru/ojs238/index.php/biopharmj/article/view/439 .
- 8. Shcherbyna, R., Parchenko, V., Varynskyi, B., Kaplaushenko, A. (2019). The development of HPLC-DAD method for determination of active pharmaceutical ingredient in the potassium 2- ((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazol-3-yl)thio)acetate substance. Current Issues in Pharmacy and Medical Sciences, 32(1), 5-9, from https://sciendo.com/downloadpdf/journals/cipms/32/1/article-p5.pdf
- 9. Shcherbyna, R., Parchenko, V., Safonov, A., Bushueva, I., Zazharskiy, V., Zazharskiy, V., Borovik, I. (2018). Synthesis and research of the impact of new derivatives of 4-R-3 (morpholinomethyl)-4H-1,2,4-triazole-5-thiol on cultural attributes of pathogenic M. Bovis. Research Journal of Pharmaceutical Biological and Chemical Sciences, 9(2), 70-79, from https://www.rjpbcs.com/pdf/2018_9(2)/[11].pdf
- 10. Shcherbyna, R. A., Panasenko, A. I., Knysh, E. G., & Varinsky, B. A. (2014). Synthesis and physicochemical properties of 2-((4-R-3-(morpholinomethylene)-4H-1,2,4-triazol-5- yl)thio)acetic acids. Current Issues in Pharmacy and Medicine: Science and Practice, 3(16), 18- 21, from http://pharmed.zsmu.edu.ua/article/view/30016/26747
- 11. Mermer, A., Demirbaş, N., Şirin, Y., Uslu, H., Özdemir, Z., Demirbaş, A. (2018). Conventional and microwave prompted synthesis, antioxidant, anticholinesterase activity screening and molecular docking studies of new quinolone-triazole hybrids. Bioorganic chemistry, 78, 236-248. [CrossRef]
- 12. Shcherbyna, R. (2019). Microwave-assisted synthesis of some new derivatives of 4-substituted- 3-(morpholinomethyl)-4H-1, 2, 4-triazole-5-thioles. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, 43(3), 220-229. [CrossRef]
- 13. Safonov, A. (2020). Microwave synthesis of new N-R-3-(alkylthio)-5-(thiophen-2-ylmethyl)- 1,2,4-triazol-4-amines. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, 44(1), 89-98. [CrossRef]
- 14. Safonov, A.A., Panasenko, O.I., Knysh, E.G., Varinsky, B.O. (2014). Synthesis and physicochemical properties of 4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol derivatives. Collection of scientific works of the Ukrainian Military Medical Academy. Problems of military health, 42, 381-385. [CrossRef]