A VİTAMİNİNİN NON-ALKOLİK YAĞLI KARACİĞER HASTALIĞINDAKİ ROLÜ

Temel bir mikro besin ögesi olan A vitamini, karaciğerdeki glukoz ve lipid homeostazının düzenlenmesi dahil olmak üzere çeşitli fizyolojik fonksiyonlarda kritik rol oynamaktadır. A vitamini vücutta temel olarak karaciğerdeki pasif hepatik yıldız hücrelerde (HYH) depolanır. Hepatositler A vitaminini metabolize eder ve A vitamini metabolitlerine yanıt olarak glukoz ve lipid metabolizması değişikliğinde rol oynar. Ancak aktif hale getirilmiş HYH'ler A vitamini içeriklerini kaybeder ve karaciğer yağlanmasının alkol tüketimine bağlı olmayan türü olan non-alkolik yağlı karaciğer hastalığı (NAYKH) gelişmesine neden olur. Bu derlemede, NAYKH 'de A vitamini metabolizması ve karaciğer hastalığının ilerlemesindeki olası rolü ile birlikte A vitamini metabolitlerinin terapötik potansiyelinin değerlendirmesi amaçlanmıştır. 

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Ankara Sağlık Bilimleri Dergisi-Cover
  • ISSN: 2146-328X
  • Yayın Aralığı: Yılda 2 Sayı
  • Başlangıç: 2012
  • Yayıncı: Ankara Üniversitesi
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