Tahir KURTULUŞ YOLDAŞ, Caner BAYDAR, Aslan YILMAZ, Hafize NALAN GÜNEŞ

Gerilim Tipi Başağrısı ve Fahr Hastalığı Birlikteliği

Fahr hastalığı; bazal ganglionlar, serebellar dentat nükleus ve sentrum semiovalede kalsifikasyon görülmesi ile karakterizedir. Bazal ganglionlar en sık tutulan bölgedir. Fahr sendromunun anoksi, radyasyon, sistemik hastalıklar, toksinler, kalsiyum metabolizma bozuklukları ve ensefalitler ile bağlantılı olduğu tammlanrruştır. Ayrıca sendromun ailesel formu bildirilmiştir. Sendromun klinik özellikleri değişik olmasına rağmen; ilerleyici mental hasar, dizartri, konvülsiyon, parkinson benzeri klinik tablo, nöro--psikiyatrik davramş ve zihinsel işlev bozuklukları Fahr sendromunda sıklıkla görülen klinik bulgulardır. Bu yazıda gerilim tipi başağrısı bulunan Fahr sendromlu bir kadın olguyu sunmayı amaçladık.

Tension Type Headache and Fahr ’s Disease

Fahr’s disease is characterized With the presence of calcifications in basal ganlions, dentate nucleus and centrum semiovale. The basal ganglia are the most common site of involvement. Fahr’s syndrome is associated with disorder of calcium metabolism, systemic illnesses, toxins, encephalitis, radiation and anoxia. Familial form of the syndrome has been reported. Although the clinic pattern of the syndrome is variable, progressive mental deterioration, dysarthria, seizures, parkinsonian features and neurobehavioral, cognitive disorders are common clinical features of the Fahr’s syndrome. In this article we present woman with Fahr’s syndrome with tension type headache.

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1. Modrego PJ, Mojonero J, Serrano M, Fayed N. Fahr’s syndrome presenting with pure and progressive presenile demantia. Neurol Sci 2005; 26: 367—369.
2. Malik R, Pandya VK, Naik D. Fahr disease. rare neurodegenerative disorder. Ind Radiol lmag 2004; 14: 383—384.
3. Beall SS, Patten BM, Mallette L, Jankovic J. Abnormal systemic metabolism of iron, porphyrin and calcium in Fahr’s syndrome. Ann Neurol 1989; 26:569—75.
4. Yoshikawa H, Abe T. Transient parkinsonism in bilateral striopallidodentate calcinosis. Pediatr Neurol, 2003; 29:75-77.
5. Baba Y, Broderick DF, Uitti RJ Hutton ML, Wszolek ZK. Heredofamilial brain calcinosis syndrome. Mayo Clin Proc, 2005; 80: 641—651.
6. Kazis A.D Contribution of CT scan to the diagnosis of Fahr’s syndrome Acta Neurol Scand 1985; 71:206—211.
7. Windeck R, Menken U. Basal ganglia calcification in pseudohypoparathyroidis typelI. Clin Endocrinol 1981; 15:57—63.
8. Victor M, Ropper AH. Calcification of vessels in basal ganglions and cerebellum (hypoparathyroidism and Fahr syndrome). In: Victor M, Bu) dm- arkadaşla“ Ropper AH (eds). Principles of Neurology. New York: McGraw—Hill; 2001:1032—1033.
9. Cartier L, Passig C, Gormaz A, Lopez J. Neuropsychological and neurophysiological features of Fahr’s disease. Rev Med Chil 2002;130:1383—1390.
10. Trautner RJ, Cummings JL, Read SL, Benson DF. Idipathic basal ganglia calcification and organic mood disorder. Am Psychiatry 1988;145:350—353.
11. Villarreal—Nunez F, Adames—Quintero AE. Late onset epilepsy as the first symptom of pseudohypoparathyroidism. Rev Neurol 2005; 41(3):155-158.
12. Karimi M, Habibzadeh F. Hypoparathyroidism with extensive intracerebral calcification in patients with beta—thalassemia major. Pediatr Endocrinol Metab 2003; 16:883—886.
13. Paprocka J, Jamroz E. Neurological Picture and 1H MRS in children with hypoparathyroidism. Przegl Lek 2005; 62:680-684.
14. Morgante L, Vita G, Meduri M, et al. Fahr’s syndrome: local inflammatory factors in the pathogenesis of calcification. Neurol 1986;233:19—22.
15. Anderson JR Intracerebral calcification in case of SLE With neurologic manifestations. Neuropathol Appl Neurobiol 1981;7 (2):161—166.
16. Illum F. Calcification of basal ganglia following carbon monoxide poisoning. Neuroradiology 1980; 19(4):213—214.
17. Kobari M, Nogawa S, Sugimoto Y, Fukuuchi Y. Familial idiopathic brain calcifications With autosomal dominant inheritance. Neurology 1997;48: 645—649.
18. Geschwind DH, Loginov M, Stern JM. Identification of locus on chromosome 14q for idipathic basal ganglia calcification (Fahr disease). Am Human Genet 1999;65:764-772.
19. Guerreiro MM, Scotoni AE. Departamento de Neurologia, Faculdade de Ciencias Medicas (FCM), Universidade Estadual de Campinas (UNICAMP), Brasil. Arq Neuropsiquiatr 1992 Dec;50(4):513—8.
20. Oliveira JR, Spiteri E, Sobrido MJ, et al. Genetic heterogeneity in familial idiopathic basal ganglia calcification (Fahr disease). Neurology 2004 ;63(11):2165—7