Astımlı Çocukların Serum D Vitamini ve Çinko Düzeyleri ile Klinik Bulguları Arasında Bir İlişki Var mı?

Amaç: Vitamin D ve çinko eksikliğinin astım ile ilişkili olduğu bildirilmektedir. Bu çalışmada astımlı çocukların klinik bulguları ile vitamin D ve çinko düzeyleri arasındaki ilişkiyi araştırmayı istedik. Materyal ve Metot: Bu prospektif çalışmaya yaşları 5‐17 arasında değişen 149 astımlı ve 97 sağlıklı çocuk dahil edildi. Tüm katılımcıların serum 25 hidroksivitamin D (25(OH)D) ve çinko düzeyleri ölçüldü, diyet alışkanlıkları, bir yıldaki solunum yolu enfeksiyonu sıklıkları, hastane başvuruları ve güneş ışığına maruziyet süreleri sorgulandı. Bulgular: Astımlı çocukların serum D vitamini ve çinko düzeyleri sırasıyla (7,7±5,29 ng/ml), (64±16,3 mcg/dl) sağlıklı çocuklardan (12,3±12,87 ng/ml), (69±26,2 mcg/dl) belirgin şekilde düşük bulundu (p

Is There a Relationship between Clinical Symptoms of Asthmatic Children and Serum Levels of Vitamin D and Zinc?

Objectives: It is reported that deficiencies in vitamin D and zinc are associated with asthma. In thisstudy we aimed to investigate the relationship between clinic findings of asthmatic children and vitaminD and zinc levels.Materials and Methods: This prospective study included a total of 149 asthmatics and 97 healthychildren with an age range of 5 to 17 years. All of the participants were evaluated for serum levels of 25 ‐hydroxyvitamin D (25(OH)D) and zinc, dietary habits, the rate of respiratory tract infections, hospitalvisits and levels of sunlight exposure.Results: Serum vitamin D and zinc levels in asthmatic children (7.7±5.29 ng/ml), (64±16.3 mcg/dl) weresignificantly lower than that in healthy children (12.3±12.87 ng/ml), (69±26.2 mcg/dl) (p< 0.015),respectively. A relationship was detected between the frequency of infection and vitamin D level’s being

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  • 1. Asher I, Pearce. Global burden of asthma among children. Int J Tuberc Lung Dis 2014;18:1269–78.
  • 2. Asher MI, Montefort S, Björkstén B et al. ISAAC Phase Three Study Group. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross‐sectional surveys. Lancet 2006;368:733–43.
  • 3. Litonjua AA, Weiss ST. Is vitamin D deficiency to blame for the asthma epidemic? J Allergy Clin Immunol 2007;120:1031‐5.
  • 4. Wjst M, Dold S. Genes, factor X, and allergens: What causes allergic diseases? Allergy 1999;54:757‐9.
  • 5. Litonjua AA, Rifas‐Shiman SL, Ly NP, et al. Maternal antioxidant intake in pregnancy and wheezing illnesses at 2 y of age. Am J Clin Nutr 2006;84:903–11.
  • 6. Nurmatov U, Devereux G, Sheikh A. Nutrients and foods for the primary prevention of asthma and allergy: Systematic review and meta‐analysis. J Allergy Clin Immunol 2011;127:724–33.
  • 7. Devereux G, Turner SW, Craig LC et al. Low maternal vitamin E intake during pregnancy is associated with asthma in 5‐year‐old children. Am J Respir Crit Care Med 2006;174:499 –507.
  • 8. Damera G, Fogle HW, Lim P, et al. Vitamin D inhibits growth of human airway smooth muscle cells through growth factor‐induced phosphorylation of retinoblastoma protein and checkpoint kinase 1. Br J Pharmacol 2009;158:1429–41.
  • 9. Bozzetto S, Carraro S, Giordano G, Boner A, Baraldi E. Asthma, allergy and respiratory infections: the vitamin D hypothesis. Allergy 2012;67:10–17.
  • 10. Ginde AA, Mansbach JM, Camargo CA Jr. Association between serum 25‐hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2009;169:384–90.
  • 11. Black PN, Scragg R. Relationship between serum 25‐hydroxyvitamin D and pulmonary function in the third national health and nutrition examination survey. Chest 2005;128:3792–98.
  • 12. Camargo CA Jr, Rifas‐Shiman SL, Litonjua AA, et al. Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age. Am J Clin Nutr 2007;85:788–95.
  • 13. Ginde AA, Sutherland RE. Vitamin D in asthma: Panacea or true promise? J Allergy Clin Immunol 2010;126:59–60.
  • 14. Brehm JM, Celedo´n JC, Soto‐Quiros ME, et al. Serum Vitamin D Levels and Markers of Severity of Childhood Asthma in Costa Rica. Am J Respir Crit Care Med 2009;179:765–71.
  • 15. Brehm JM, Schuemann B, Fuhlbrigge AL, et al. Childhood Asthma Management Program Research Group. Serum vitamin D levels and severe asthma exacerbations in the childhood asthma management program study. J Allergy Clin Immunol 2010;126:52–8.
  • 16. Hughes DA, Norton R. Vitamin D and respiratory health. Clin Exp Immunol 2009;158:20–5.
  • 17. Walker VP, Modlin RL. The vitamin D connection to pediatric infections and immune function. Pediatr Res 2009;65:106–13.
  • 18. Bener A, Ehlayel MS, Tulic MK, Hamid Q. Vitamin D deficiency as a strong predictor of asthma in children. Int Arch Allergy Immunol 2012;157:168–75.
  • 19. Arik Yılmaz E, Ozmen S, Bostancı I, Misirlioglu ED, Ertan U. Erythrocyte zinc levels in children with bronchial asthma. Pediatric Pulmonology 2011;4612:1189–93.
  • 20. Park SY, Birkhold SG, Kubena LF, Nisbet DJ, Ricke SC. Review on the role of dietary zinc in poultry nutrition, immunity, and reproduction. Biol Trace Elem Res 2004;101:147–63.
  • 21. Kumar J, Muntner P, Kaskel FJ, Hailpern SM, Melamed ML. Prevalence and association of 25‐ hydroxyvitamin D deficiency in US children: NHANES III. 2001‐2004. Pediatrics 2009;124:362–70.
  • 22. Uysalol M, Uysalol EP, Yilmaz Y, et al. Serum level of vitamin D and trace elements in children with recurrent wheezing a cross‐sectional study. BMC Pediatrics 2014;14:270.
  • 23. Türe M, Zeyrek DC, Koçyiğit A. Hışıltılı çocuklarda serum D vitamini, folik asit ve B12 düzeyi. Asthma Allergy Immunol 2013;11:169–77.
  • 24. Gultekin A, Ozalp I, Hasanoglu A, Unal A. Serum 25‐hydroxycholecalciferol levels in children and adolescents. Turk J Pediatr 1987;29:155‐62.
  • 25. Taneli B. Zinc in Anatolian Population. Ege J Med 2005;44:1–10.
  • 26. Hodge L, Salome CM, Hughes JM, et al. Effects of dietary intake of omega‐3 and omega‐6 fatty acids on severity of asthma in children. Eur Respir J 1998;11:361–65.
  • 27. Turkeli A, Ayaz O, Uncu A, et al. Effects of vitamin D levels on asthma control and severity in preschool children. Eur Rev Med Pharmacol Sci 2016;20(1):26‐36.
  • 28. Xystrakis E, Kusumakar S, Boswell S, et al. Reversing the defective induction of IL–10‐secreting regulatory T cells in glucocorticoid‐resistant asthma patients. J Clin Invest 2006;116:146–55.
  • 29. Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in school children. Am J Clin Nutr 2010;91:1255– 60.
  • 30. Majak P, Olszowiec‐Chlebna M, Smejda K, Stelmach I. Vitamin D supplementation in children may prevent asthma exacerbation triggered by acute respiratory infection. J Allergy Clin Immunol 2011;127:1294–96.
  • 31. Jolliffe DA, Greenberg L, Hooper RL et al. Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta‐analysis of individual participant data. Lancet Respir Med. 2017;11:881‐90.
  • 32. Ghaffari J, Khalilian A, Salehifar E, Khorasani E, Rezaii MS. Effect of zinc supplementation in children with asthma: a randomized, placebo‐controlled trial in northern Islamic Republic of Iran. East Mediterr Health J 2014;20:391‐96.
Ankara Medical Journal-Cover
  • Başlangıç: 2014
  • Yayıncı: Ankara Yıldırım Beyazıt Üniversitesi Tıp Fakültesi
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