Acil Serviste Renal Koliği Olan Hastalarda Tiyol/Disülfid Homeostazı Nötrofil Lenfosit ve Platelet Lenfosit Oranı
Amaç: Bu çalışmanın amacı acil servise renal kolik nedeniyle başvuran hastalarda oksidatif stres markerlarından olan tiyol/disülfid homeostazı parametreleri ile Nötrofil‐Lenfosit ve Platelet‐Lenfosit oranlarının (NLO, PLO) beraber kullanımının tanı açısından yararlı olup olmadığını araştırmaktır. Materyal ve Metot: Çalışma 15.05.2018 ile 01.10.2018 tarihleri arasında acil servise başvuran ve çalışmaya alınan 75 hasta ve kontrol grubu olarak belirlenen 47 sağlıklı kişi ile prospektif olarak yapıldı. Erel ve Neşelioğlu tarafından yeni geliştirilen bir metot ile oksidatif stres belirteci olan tiyol/disülfid homeostaz parametreleri ( Tiyol, disülfid, disülfid / native tiyol, disüfid / total tiyol, native tiyol / total tiyol) ile NLO ve PLO hasta ve kontrol grubunda çalışıldı. Üriner taş hastalığı olan ve olmayanlar arasında bu parametreler karşılaştırıldı. Bulgular: Renal koliği olanlarda kontrol grubuna göre, NLO, PLO, disülfid, disülfid /native tiyol ve disülfid /total tiyol ortalama değerleri anlamlı derecede yüksek bulunurken (sırasıyla p= 0.010,
Thiol/Disulphide Homeostasis Neutrophil Lymphocyte and Platelet Lymphocyte Ratio in Emergency Department Patients with Renal Colic
Objectives: This study's aim is to investigate if using thiol/disulphide homeostasis parameters whichare oxidative stress markers together with Neutrophile‐Lymphocyte and Platelet‐Lymphocyte ratio(NLR, PLR) is diagnostically useful in the patients who present to the emergency department with renalcolic.Materials and Methods: The study was made prospectively with 75 patients who were admitted to theemergency department between 15.05.2018 and 01.10.2018 and 47 healthy subjects who were determinedas control group. Thiol/disulphide homeostasis parameters (thiol, disulphide, disulphide / native thiol,disulphide / total thiol, native thiol / total thiol) which are oxidative stress markers are measured by anew method which was developed by Erel and Neşelioğlu in the patient and control groups, also NLRand PLR were studied. These parameters were compared also between the patient groups with urinarystone disease and that without.Results: NLR, PLR, disulphide, disulphide /native thiol and disulphide /total thiol average values werefound significantly high (respectively p= 0.010,
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