Mehmet İlker YÖN, Selda KESKİN GÜLER, Hafize Nalan GÜNEŞ, Gökçe Burcu ÇOKAL, Cemile SENCER DEMİRCAN, Tahir Kurtuluş YOLDAŞ

TEKRARLAYAN TRANSVERS MİYELİT SONRASINDA GELİŞEN NÖROMİYELİTİS OPTİKA

Nöromyelitis optika NMO veya Devic hastalığı, santral sinir sisteminde ağırlıklı olarak optik sinir ve spinal kord tutulumuna neden olan idiopatik, immün aracılı ve inflamatuar demyelinizan bir hastalıktır. NMO'nun ana klinik özellikleri optik nörit ve transvers myelittir. NMO transvers myeliti genellikle ağırdır ve 3 veya daha fazla vertebra segmenti boyunca uzanan longitüdinal olarak yaygın transvers miyelittir longitüdinal ekstensiv transvers miyelit= LETM . LETM genellikle NMO ile ilişkili olup, sistemik otoimmün hastalıklar Sjögren sendromu,sistemik lupus eritematozus, antifosfolipid sendromu , nöroinflamatuvar durumlar Behçet hastalığı, sarkoidozis , multipl skleroz ve enfeksiyöz hastalıklar da göz önünde bulundurulmalıdır

Anahtar Kelimeler:

Neuromyelitis Optica, transvers miyelit, optik nörit

NEUROMYELITIS OPTICA DEVELOPİNG AFTER RECURRENT TRANSVERS MYELİTİS

Neuromyelitis optica NMO or Devic’s disease, is an idiopathic immune-mediated inflammatory demyelinating disease of the central nervous system mainly affecting the optic nerve and spinal cord. The main clinical characteristics of NMO are optic neuritis and transverse myelitis TM . NMO-TM is usually severe and typically longitudinally extensive TM LETM ; extending over 3 or more vertebral segments. LETM is usually associated with neuromyelitis optica NMO , but systemic autoimmune diseases Sjögren’s syndrome SS , systemic lupus erythematosus SLE , antiphospholipid syndrome, neuroinflammatory conditions Behcet’s disease, sarcoidosis , multiple sclerosis MS , and infectious diseases should always be considered. The correct diagnosis of NMO is of paramount importance for giving appropriate therapy. NMO is different from other demyelinating diseases clinically, radiologically, pathologically and in terms of treatment approaches

Keywords:

Neuromyelitis optica, transverse myelitis, optic neuritis,

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)Downer, J.J., et al., Diagnosis of neuromyelitis optica (NMO) spectrum disorders: is MRI obsolete? Neuroradiology. 2012; 54: 85.
)Chia, W.C., J.N. Wang, and M.C. Lai, Neuromyelitis optica: a case report. Pediatr Neonatol. 2010; 51: 347-52.
)Matsumoto, H., et al., Recurrent spinal cord attacks in a patient with a limited form of neuromyelitis optica. Intern Med. 2011; : 509-13.
)Wingerchuk, D.M., et al., Revised diagnostic criteria for neuromyelitis optica. Neurology. 2006; 66: 1485-9.
)Nightingale, H., J. Witherick, and A. Wilkins, Diagnosis of lon- gitudinally extensive transverse myelitis. BMJ Case Rep, 2011.
)Tobin, W.O., B.G. Weinshenker, and C.F. Lucchinetti, Longi- tudinally extensive transverse myelitis. Curr Opin Neurol. 2014; : 279-89.
)Kira, J., Multiple sclerosis in the Japanese population. Lancet Neurol. 2003; 2: 117-27.
)Sellner, J., et al., EFNS guidelines on diagnosis and manage- ment of neuromyelitis optica. Eur J Neurol. 2010; 17: 1019-32.
)Merle, H., et al., Natural history of the visual impairment of re- lapsing neuromyelitis optica. Ophthalmology. 2007; 114: 810-5.
) Wingerchuk, D.M. and B.G. Weinshenker, Neuromyelitis op- tica: clinical predictors of a relapsing course and survival. Neuro- logy. 2003; 60: 848-53.
) Wingerchuk, D.M., et al., The spectrum of neuromyelitis op- tica. Lancet Neurol. 2007; 6: 805-15.
) O'Riordan, J.I., et al., Clinical, CSF, and MRI findings in De- vic's neuromyelitis optica. J Neurol Neurosurg Psychiatry. 1996; : 382-7.
) Wingerchuk, D.M., et al., The clinical course of neuromyelitis optica (Devic's syndrome). Neurology. 1999; 53: 1107-14.
) de Seze, J., et al., Devic's neuromyelitis optica: clinical, labo- ratory, MRI and outcome profile. J Neurol Sci. 2002; 197: 57-61.
) Nakamura, M., et al., Preferential spinal central gray matter involvement in neuromyelitis optica. An MRI study. J Neurol. , 255: 163-70. ) Krampla, W., et al., Spinal cord lesions in patients with neuromyelitis optica: a retrospective long-term MRI follow-up study. Eur Radiol. 2009; 19: 2535-43.
) Pittock, S.J., et al., Brain abnormalities in neuromyelitis opti- ca. Arch Neurol. 2006; 63: 390-6.
) Pittock, S.J., et al., Neuromyelitis optica brain lesions localized at sites of high aquaporin 4 expression. Arch Neurol. 2006; 63: 8.
) Bichuetti, D.B., et al., Neuromyelitis optica in Brazil: a study on clinical and prognostic factors. Mult Scler. 2009; 15: 613-9.
)Bergamaschi, R., et al., Oligoclonal bands in Devic's neurom- yelitis optica and multiple sclerosis: differences in repeated ce- rebrospinal fluid examinations. Mult Scler. 2004; 10: 2-4.
)Pittock, S.J., et al., Neuromyelitis optica and non organ-speci- fic autoimmunity. Arch Neurol. 2008, 65: 78-83.